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P80857 (SODF_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Superoxide dismutase [Fe]
EC=1.15.1.1
Gene names
Name:sod
Ordered Locus Names:SSO0316
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activity

2 superoxide + 2 H+ = O2 + H2O2.

Cofactor

Binds 1 iron ion per subunit.

Subunit structure

Homotetramer. Ref.5

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the iron/manganese superoxide dismutase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological processsuperoxide metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

superoxide dismutase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 211210Superoxide dismutase [Fe]
PRO_0000160010

Sites

Metal binding341Iron
Metal binding851Iron
Metal binding1711Iron
Metal binding1751Iron

Secondary structure

1 ................................. 211
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P80857 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 693C2C94B9A3D630

FASTA21124,244
        10         20         30         40         50         60 
MTLQIQFKKY ELPPLPYKID ALEPYISKDI IDVHYNGHHK GYVNGANSLL ERLEKVVKGD 

        70         80         90        100        110        120 
LQTGQYDIQG IIRGLTFNIN GHKLHALYWE NMAPSGKGGG KPGGALADLI NKQYGSFDRF 

       130        140        150        160        170        180 
KQVFTETANS LPGTGWAVLY YDTESGNLQI MTFENHFQNH IAEIPIILIL DEFEHAYYLQ 

       190        200        210 
YKNKRADYVN AWWNVVNWDA AEKKLQKYLT K

« Hide

References

« Hide 'large scale' references
[1]"An azide-insensitive superoxide dismutase from a hyperthermophilic archaeon, Sulfolobus solfataricus."
Yamano S., Maruyama T.
J. Biochem. 125:186-193(1999) [PubMed: 9880816] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Phenylmethanesulfonyl fluoride inactivates an archaeal superoxide dismutase by chemical modification of a specific tyrosine residue: cloning, sequencing and expression of the gene coding for Sulfolobus solfataricus superoxide dismutase."
De Vendittis E., Ursby T., Rullo R., Gogliettino M.A., Masullo M., Bocchini V.
Eur. J. Biochem. 268:1794-1801(2001) [PubMed: 11248699] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 5833 / MT-4.
[3]"The complete genome of the crenarchaeon Sulfolobus solfataricus P2."
She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. expand/collapse author list , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.
Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[4]"Iron superoxide dismutase from the archaeon Sulfolobus solfataricus: average hydrophobicity and amino acid weight are involved in the adaptation of proteins to extreme environments."
Dello Russo A., Rullo R., Nitti G., Masullo M., Bocchini V.
Biochim. Biophys. Acta 1343:23-30(1997) [PubMed: 9428655] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-211.
Strain: DSM 5833 / MT-4.
[5]"Iron superoxide dismutase from the archaeon Sulfolobus solfataricus: analysis of structure and thermostability."
Ursby T., Adinolfi B.S., Al-Karadaghi S., de Vendittis E., Bocchini V.
J. Mol. Biol. 286:189-205(1999) [PubMed: 9931259] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH IRON IONS, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB012620 Genomic DNA. Translation: BAA75509.1.
Y15326 Genomic DNA. Translation: CAA75583.1.
AE006641 Genomic DNA. Translation: AAK40652.1.
PIRE90174.
RefSeqNP_341862.1. NC_002754.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WB7X-ray2.24A/B2-210[»]
1WB8X-ray2.30A/B2-211[»]
ProteinModelPortalP80857.
SMRP80857. Positions 5-209.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1455462.
GenomeReviewsGene locus SSO0316 in contig AE006641_GR.
KEGGsso:SSO0316.
NMPDRfig|273057.1.peg.285.

Phylogenomic databases

HOGENOMHBG507761.
OMAQVEKHNV.
ProtClustDBCLSK883633.

Enzyme and pathway databases

BioCycSSOL273057:SSO0316-MONOMER.
BRENDA1.15.1.1. 6163.

Family and domain databases

InterProIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
KOK04564.
PANTHERPTHR11404. SODismutase. 1 hit.
PfamPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFPIRSF000349. SODismutase. 1 hit.
PRINTSPR01703. MNSODISMTASE.
SUPFAMSSF46609. SODismutase. 1 hit.
SSF54719. SODismutase. 1 hit.
PROSITEPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSODF_SULSO
AccessionPrimary (citable) accession number: P80857
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: December 14, 2011
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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