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Protein

Superoxide dismutase [Fe]

Gene

sod

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Fe cationNote: Binds 1 Fe cation per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi34 – 341Iron
Metal bindingi85 – 851Iron
Metal bindingi171 – 1711Iron
Metal bindingi175 – 1751Iron

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-304-MONOMER.
BRENDAi1.15.1.1. 6163.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Fe] (EC:1.15.1.1)
Gene namesi
Name:sod
Ordered Locus Names:SSO0316
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 211210Superoxide dismutase [Fe]PRO_0000160010Add
BLAST

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi273057.SSO0316.

Structurei

Secondary structure

1
211
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni19 – 257Combined sources
Helixi28 – 369Combined sources
Helixi38 – 5720Combined sources
Beta strandi59 – 613Combined sources
Helixi68 – 9023Combined sources
Beta strandi98 – 1003Combined sources
Helixi104 – 11411Combined sources
Helixi117 – 12913Combined sources
Beta strandi133 – 1419Combined sources
Turni143 – 1453Combined sources
Beta strandi148 – 1547Combined sources
Turni155 – 1573Combined sources
Beta strandi166 – 1716Combined sources
Helixi174 – 1763Combined sources
Helixi178 – 1814Combined sources
Helixi185 – 1928Combined sources
Helixi193 – 1953Combined sources
Helixi198 – 2069Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WB7X-ray2.24A/B2-211[»]
1WB8X-ray2.30A/B2-211[»]
ProteinModelPortaliP80857.
SMRiP80857. Positions 5-209.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80857.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG04147. Archaea.
COG0605. LUCA.
HOGENOMiHOG000013583.
InParanoidiP80857.
KOiK04564.
OMAiEQVYDHQ.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLQIQFKKY ELPPLPYKID ALEPYISKDI IDVHYNGHHK GYVNGANSLL
60 70 80 90 100
ERLEKVVKGD LQTGQYDIQG IIRGLTFNIN GHKLHALYWE NMAPSGKGGG
110 120 130 140 150
KPGGALADLI NKQYGSFDRF KQVFTETANS LPGTGWAVLY YDTESGNLQI
160 170 180 190 200
MTFENHFQNH IAEIPIILIL DEFEHAYYLQ YKNKRADYVN AWWNVVNWDA
210
AEKKLQKYLT K
Length:211
Mass (Da):24,244
Last modified:January 23, 2007 - v2
Checksum:i693C2C94B9A3D630
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012620 Genomic DNA. Translation: BAA75509.1.
Y15326 Genomic DNA. Translation: CAA75583.1.
AE006641 Genomic DNA. Translation: AAK40652.1.
PIRiE90174.
RefSeqiWP_009990609.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40652; AAK40652; SSO0316.
GeneIDi27426612.
KEGGisso:SSO0316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012620 Genomic DNA. Translation: BAA75509.1.
Y15326 Genomic DNA. Translation: CAA75583.1.
AE006641 Genomic DNA. Translation: AAK40652.1.
PIRiE90174.
RefSeqiWP_009990609.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WB7X-ray2.24A/B2-211[»]
1WB8X-ray2.30A/B2-211[»]
ProteinModelPortaliP80857.
SMRiP80857. Positions 5-209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0316.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40652; AAK40652; SSO0316.
GeneIDi27426612.
KEGGisso:SSO0316.

Phylogenomic databases

eggNOGiarCOG04147. Archaea.
COG0605. LUCA.
HOGENOMiHOG000013583.
InParanoidiP80857.
KOiK04564.
OMAiEQVYDHQ.

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-304-MONOMER.
BRENDAi1.15.1.1. 6163.

Miscellaneous databases

EvolutionaryTraceiP80857.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An azide-insensitive superoxide dismutase from a hyperthermophilic archaeon, Sulfolobus solfataricus."
    Yamano S., Maruyama T.
    J. Biochem. 125:186-193(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Phenylmethanesulfonyl fluoride inactivates an archaeal superoxide dismutase by chemical modification of a specific tyrosine residue: cloning, sequencing and expression of the gene coding for Sulfolobus solfataricus superoxide dismutase."
    De Vendittis E., Ursby T., Rullo R., Gogliettino M.A., Masullo M., Bocchini V.
    Eur. J. Biochem. 268:1794-1801(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 5833 / MT-4.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  4. "Iron superoxide dismutase from the archaeon Sulfolobus solfataricus: average hydrophobicity and amino acid weight are involved in the adaptation of proteins to extreme environments."
    Dello Russo A., Rullo R., Nitti G., Masullo M., Bocchini V.
    Biochim. Biophys. Acta 1343:23-30(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-211.
    Strain: DSM 5833 / MT-4.
  5. "Iron superoxide dismutase from the archaeon Sulfolobus solfataricus: analysis of structure and thermostability."
    Ursby T., Adinolfi B.S., Al-Karadaghi S., de Vendittis E., Bocchini V.
    J. Mol. Biol. 286:189-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH IRON IONS, SUBUNIT.

Entry informationi

Entry nameiSODF_SULSO
AccessioniPrimary (citable) accession number: P80857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.