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Protein

Immunoglobulin lambda variable 3-21

Gene

IGLV3-21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).4 Publications

GO - Molecular functioni

  • antigen binding Source: UniProtKB
  • serine-type endopeptidase activity Source: Reactome

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-2168880. Scavenging of heme from plasma.
R-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-5690714. CD22 mediated BCR regulation.
R-HSA-977606. Regulation of Complement cascade.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Protein family/group databases

IMGT/GENE-DBIGLV3-21.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin lambda variable 3-212 Publications
Alternative name(s):
Ig lambda chain V-III region LOI1 Publication
Ig lambda chain V-V region DEL1 Publication
Ig lambda chain V-VII region MOT1 Publication
Gene namesi
Name:IGLV3-212 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:5905. IGLV3-21.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • plasma membrane Source: Reactome

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi28796.
OpenTargetsiENSG00000211662.

Polymorphism and mutation databases

DMDMi126571.
126577.
6016518.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000005984318 – 117Immunoglobulin lambda variable 3-211 PublicationAdd BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 106PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PeptideAtlasiP80748.
PRIDEiP80748.

Expressioni

Gene expression databases

BgeeiENSG00000211662.

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LOImodel-A/B21-117[»]
ProteinModelPortaliP80748.
SMRiP80748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – ›117Ig-likePROSITE-ProRule annotationAdd BLAST›100

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

GeneTreeiENSGT00780000121842.
HOVERGENiHBG018013.
OMAiNKYVHWY.
PhylomeDBiP80748.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWTVLLLGL LSHCTGSVTS YVLTQPPSVS VAPGQTARIT CGGNNIGSKS
60 70 80 90 100
VHWYQQKPGQ APVLVVYDDS DRPSGIPERF SGSNSGNTAT LTISRVEAGD
110
EADYYCQVWD SSSDHPT
Length:117
Mass (Da):12,446
Last modified:November 2, 2016 - v2
Checksum:iB678ABFF5F22FDED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20 – 22SYV → FYE AA sequence (PubMed:6780787).Curated3
Sequence conflicti24T → S AA sequence (PubMed:4452363).Curated1
Sequence conflicti31 – 33VAP → LAA AA sequence (PubMed:6780787).Curated3
Sequence conflicti35Q → E AA sequence (PubMed:10510403).Curated1
Sequence conflicti38R → M AA sequence (PubMed:6780787).Curated1
Sequence conflicti39I → L AA sequence (PubMed:10510403).Curated1
Sequence conflicti42G → E AA sequence (PubMed:6780787).Curated1
Sequence conflicti45N → D AA sequence (PubMed:10510403).Curated1
Sequence conflicti45N → D AA sequence (PubMed:4452363).Curated1
Sequence conflicti45N → D AA sequence (PubMed:6780787).Curated1
Sequence conflicti45N → G AA sequence (PubMed:4452363).Curated1
Sequence conflicti48 – 49SK → ER AA sequence (PubMed:6780787).Curated2
Sequence conflicti48S → G AA sequence (PubMed:4452363).Curated1
Sequence conflicti49K → E AA sequence (PubMed:10510403).Curated1
Sequence conflicti64 – 66LVV → PVI AA sequence (PubMed:6780787).Curated3
Sequence conflicti66 – 70VYDDS → IYFDR AA sequence (PubMed:10510403).Curated5
Sequence conflicti67 – 74YDDSDRPS → HEDNDRPA AA sequence (PubMed:4452363).Curated8
Sequence conflicti70S → A AA sequence (PubMed:6780787).Curated1
Sequence conflicti76 – 78IPE → VPA AA sequence (PubMed:6780787).Curated3
Sequence conflicti83S → Y AA sequence (PubMed:6780787).Curated1
Sequence conflicti88T → S AA sequence (PubMed:6780787).Curated1
Sequence conflicti90T → A AA sequence (PubMed:4452363).Curated1
Sequence conflicti90T → I AA sequence (PubMed:4452363).Curated1
Sequence conflicti94S → N AA sequence (PubMed:6780787).Curated1
Sequence conflicti105Y → F AA sequence (PubMed:6780787).Curated1
Sequence conflicti107Q → E AA sequence (PubMed:4452363).Curated1
Sequence conflicti108V → L AA sequence (PubMed:10510403).Curated1
Sequence conflicti108V → S AA sequence (PubMed:6780787).Curated1
Sequence conflicti111 – 117SSSDHPT → DRTAHVV AA sequence (PubMed:4452363).Curated7
Sequence conflicti111 – 117SSSDHPT → NGSYEVV AA sequence (PubMed:6780787).Curated7
Sequence conflicti114 – 117DHPT → EHVV AA sequence (PubMed:10510403).Curated4
Non-terminal residuei1171

Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGLV3-21*02.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244250 Genomic DNA. No translation available.
PIRiA01985. L5HUDL.
A01986. L7HUMT.
UniGeneiHs.449585.
Hs.625768.

Genome annotation databases

EnsembliENST00000390308; ENSP00000374843; ENSG00000211662.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLV321_HUMAN
AccessioniPrimary (citable) accession number: P80748
Secondary accession number(s): A0A075B6J7, P01719, P01720
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 2, 2016
Last modified: August 30, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

For an example of a full length immunoglobulin lambda light chain see AC P0DOX8.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references