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Protein

Integrin alpha-V

Gene

ITGAV

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The alpha-V (ITGAV) integrins are receptors for vitronectin, MFGE8, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi260 – 2689Sequence Analysis
Calcium bindingi314 – 3229Sequence Analysis
Calcium bindingi379 – 3879Sequence Analysis
Calcium bindingi443 – 4519Sequence Analysis

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. blood vessel development Source: AgBase
  2. cell adhesion Source: UniProtKB-KW
  3. integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Integrin, Receptor

Keywords - Biological processi

Cell adhesion, Host-virus interaction

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-V
Alternative name(s):
Vitronectin receptor subunit alpha
CD_antigen: CD51
Cleaved into the following 2 chains:
Gene namesi
Name:ITGAV
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 992962ExtracellularSequence AnalysisAdd
BLAST
Transmembranei993 – 101624HelicalSequence AnalysisAdd
BLAST
Topological domaini1017 – 104832CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 30301 PublicationAdd
BLAST
Chaini31 – 10481018Integrin alpha-VPRO_0000016298Add
BLAST
Chaini31 – 889859Integrin alpha-V heavy chainPRO_0000016299Add
BLAST
Chaini891 – 1048158Integrin alpha-V light chainPRO_0000016300Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi89 ↔ 97By similarity
Disulfide bondi138 ↔ 158By similarity
Disulfide bondi172 ↔ 185By similarity
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi491 ↔ 502By similarity
Disulfide bondi508 ↔ 565By similarity
Glycosylationi554 – 5541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi615 – 6151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi626 ↔ 632By similarity
Disulfide bondi698 ↔ 711By similarity
Glycosylationi704 – 7041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi835 – 8351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi851 – 8511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi852 ↔ 914Interchain (between heavy and light chains)By similarity
Glycosylationi874 – 8741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi904 ↔ 909By similarity
Glycosylationi945 – 9451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi973 – 9731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi980 – 9801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP80746.
PRIDEiP80746.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-V (ITGAV) associates with either beta-1 (ITGB1), beta-3 (ITGB3), beta-5 (ITGB5), beta-6 (ITGB6) or beta-8 (ITGB8). Interacts with RAB25. Interacts with CIB1. Integrins ITGAV:ITGB3 and ITGAV:ITGB5 interact with FBLN5 (via N-terminus) (By similarity). Alpha-V/beta-6 and alpha-V/beta-3 bind to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (PubMed:10906183, PubMed:12551988).By similarity2 Publications

Protein-protein interaction databases

IntActiP80746. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP80746.
SMRiP80746. Positions 31-986.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati32 – 9867FG-GAP 1Add
BLAST
Repeati109 – 17062FG-GAP 2Add
BLAST
Repeati173 – 22553FG-GAP 3Add
BLAST
Repeati237 – 29559FG-GAP 4Add
BLAST
Repeati296 – 35762FG-GAP 5Add
BLAST
Repeati358 – 41558FG-GAP 6Add
BLAST
Repeati419 – 48264FG-GAP 7Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1019 – 10235GFFKR motif

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26407.
HOGENOMiHOG000231603.
HOVERGENiHBG006186.
InParanoidiP80746.
KOiK06487.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFPPRRRLR LGPRGLPLLL SGLLLPLCRA FNLDVESPAE YSGPEGSYFG
60 70 80 90 100
FAVDFFVPSA SSRMFLLVGA PKANTTQPGI VEGGQVLKCD WSSHRRCQPI
110 120 130 140 150
EFDATGNRDY AKDDPLEFKS HQWFGASVRS KQDKILACAP LYHWRTEMKQ
160 170 180 190 200
EREPVGTCFL QDGTKTVEYA PCRSKNIDAD GQGFCQGGFS IDFTKADRVL
210 220 230 240 250
LGGPGSFYWQ GQLISDQVAE IVSKYDPKVY SIKYNNQLAT RTAQAIFDDS
260 270 280 290 300
YLGYSVAVGD FNGDGIDDFV SGVPRAARTL GMVYIYDGKN MSSLHNFTGE
310 320 330 340 350
QMAAYFGFSV AATDINGDDY ADVFIGAPLF MDRGSDGKLQ EVGQVSVSLQ
360 370 380 390 400
KASGDFQTIK LNGFEVFARF GSAIAPLGDL DQDGFNDIAI AAPYGGEDKK
410 420 430 440 450
GIVYIFNGRP TGLNAVPSQI LEGKWAARSM PPSFGYSMKG ATDIDKNGYP
460 470 480 490 500
DLIVGAFGVD RAVLYRARPV ITVNAGLEVY PSILNQENKT CPLPGTDLKV
510 520 530 540 550
SCFNVRFCLK ADGKGALPTK LDFQVELLLD KLKQKGAIRR ALFLHNRSPG
560 570 580 590 600
HSKNMTISRG GQMQCEELIA YLRDESEFRD KLTPITIFME YWLDYRTAAD
610 620 630 640 650
ATGLQPILNQ FTPANVSRQA HILLDCGEDN VCKPKLEVSV DSDQKKIYIG
660 670 680 690 700
DDNPLTLIVK AQNQGEGAYE AELIVSIPLQ ADFIGVVRNS EALARLSCAF
710 720 730 740 750
KTENQTRQVV CDLGNPMKAG TQLLAGLRFS VHQQSEMDTS VKFDLQIQSS
760 770 780 790 800
NLFDKVSPVV SYKVDLAVLA AVEIRGVSSP DHIFLPIPNW KYKENPETEE
810 820 830 840 850
DVGPVVQHIY ELRNNGPSSF SKAMLHLQWP YKYNNNTLLY ILQYDIDGPM
860 870 880 890 900
NCTSDMEINP LRIKISNSQT SEKNDTVGGQ GDRNHLITKR DLTLNEGDVH
910 920 930 940 950
TLGCGIAECL KIVCQVGRLD RGKSAILYVR SLLWTETFMN KENQNHSYSL
960 970 980 990 1000
KSSASFNVIE FPYKNLPIED IFNSTLVTTN VTWGIQPAPM PVPVWVIILA
1010 1020 1030 1040
VLAGLLLLAV LVFVMYRMGF FKRVRPPQEE QEREQLQPHE NGEGNSET
Length:1,048
Mass (Da):116,132
Last modified:January 23, 2007 - v3
Checksum:iA6A5620EB3144502
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121G → R in ABH07896 (Ref. 2) Curated
Sequence conflicti15 – 173GLP → RLL in ABH07896 (Ref. 2) Curated
Sequence conflicti21 – 233SGL → PGI in ABH07896 (Ref. 2) Curated
Sequence conflicti29 – 291R → G in ABH07896 (Ref. 2) Curated
Sequence conflicti63 – 631Missing in AAF44691 (PubMed:10906183).Curated
Sequence conflicti152 – 1521R → G in AAG38595 (Ref. 3) Curated
Sequence conflicti189 – 1891F → S in ABH07896 (Ref. 2) Curated
Sequence conflicti242 – 2421T → I in ABH07896 (Ref. 2) Curated
Sequence conflicti354 – 3541G → R in AAF44691 (PubMed:10906183).Curated
Sequence conflicti415 – 4151A → T in AAF44691 (PubMed:10906183).Curated
Sequence conflicti621 – 6211H → R in AAF44691 (PubMed:10906183).Curated
Sequence conflicti629 – 6291D → G in AAF44691 (PubMed:10906183).Curated
Sequence conflicti860 – 8601P → R in AAG38595 (Ref. 3) Curated
Sequence conflicti870 – 8701T → A in AAG38595 (Ref. 3) Curated
Sequence conflicti873 – 8731K → R in AAF44691 (PubMed:10906183).Curated
Sequence conflicti894 – 8941L → V AA sequence (PubMed:9154926).Curated
Sequence conflicti977 – 9771V → I in ABH07896 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239958 mRNA. Translation: AAF44691.2.
DQ871215 mRNA. Translation: ABH07896.1.
AF317199 mRNA. Translation: AAG38595.1.
RefSeqiNP_776792.1. NM_174367.1.
UniGeneiBt.5273.

Genome annotation databases

GeneIDi281875.
KEGGibta:281875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239958 mRNA. Translation: AAF44691.2.
DQ871215 mRNA. Translation: ABH07896.1.
AF317199 mRNA. Translation: AAG38595.1.
RefSeqiNP_776792.1. NM_174367.1.
UniGeneiBt.5273.

3D structure databases

ProteinModelPortaliP80746.
SMRiP80746. Positions 31-986.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP80746. 1 interaction.

Proteomic databases

PaxDbiP80746.
PRIDEiP80746.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281875.
KEGGibta:281875.

Organism-specific databases

CTDi3685.

Phylogenomic databases

eggNOGiNOG26407.
HOGENOMiHOG000231603.
HOVERGENiHBG006186.
InParanoidiP80746.
KOiK06487.

Miscellaneous databases

NextBioi20805777.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency utilization of the bovine integrin alpha(v)beta(3) as a receptor for foot-and-mouth disease virus is dependent on the bovine beta(3) subunit."
    Neff S., Mason P.W., Baxt B.
    J. Virol. 74:7298-7306(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH FMDV CAPSID PROTEINS.
    Tissue: Lung.
  2. "Molecular cloning and characteristics of bovine alpha V cDNA."
    Du J., Chang H., Cong G., Shao J., Lin T., Liu Z., Liu X., Cai X., Xie Q.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  3. "Bovine alpha-V integrin subunit (fragment)."
    Andersen M.H., Rasmussen J.T., Berglund L., Petersen T.E.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-1048.
    Tissue: Mammary gland.
  4. "Bovine PAS-6/7 binds alpha v beta 5 integrins and anionic phospholipids through two domains."
    Andersen M.H., Berglund L., Rasmussen J.T., Petersen T.E.
    Biochemistry 36:5441-5446(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 31-50 AND 891-910.
    Tissue: Mammary gland.
  5. "Foot-and-mouth disease virus receptors: comparison of bovine alpha(V) integrin utilization by type A and O viruses."
    Duque H., Baxt B.
    J. Virol. 77:2500-2511(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOST FMDV VP1.

Entry informationi

Entry nameiITAV_BOVIN
AccessioniPrimary (citable) accession number: P80746
Secondary accession number(s): Q0PDN6, Q9GK48, Q9MZD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.