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P80746

- ITAV_BOVIN

UniProt

P80746 - ITAV_BOVIN

Protein

Integrin alpha-V

Gene

ITGAV

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    The alpha-V integrins are receptors for vitronectin, MFGE8, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi260 – 2689Sequence Analysis
    Calcium bindingi314 – 3229Sequence Analysis
    Calcium bindingi379 – 3879Sequence Analysis
    Calcium bindingi443 – 4519Sequence Analysis

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. virus receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. blood vessel development Source: AgBase
    2. cell adhesion Source: UniProtKB-KW
    3. integrin-mediated signaling pathway Source: UniProtKB-KW
    4. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Host cell receptor for virus entry, Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion, Host-virus interaction

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin alpha-V
    Alternative name(s):
    Vitronectin receptor subunit alpha
    CD_antigen: CD51
    Cleaved into the following 2 chains:
    Gene namesi
    Name:ITGAV
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integrin complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 30301 PublicationAdd
    BLAST
    Chaini31 – 10481018Integrin alpha-VPRO_0000016298Add
    BLAST
    Chaini31 – 889859Integrin alpha-V heavy chainPRO_0000016299Add
    BLAST
    Chaini891 – 1048158Integrin alpha-V light chainPRO_0000016300Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi89 ↔ 97By similarity
    Disulfide bondi138 ↔ 158By similarity
    Disulfide bondi172 ↔ 185By similarity
    Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi491 ↔ 502By similarity
    Disulfide bondi508 ↔ 565By similarity
    Glycosylationi554 – 5541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi615 – 6151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi626 ↔ 632By similarity
    Disulfide bondi698 ↔ 711By similarity
    Glycosylationi704 – 7041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi835 – 8351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi851 – 8511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi852 ↔ 914Interchain (between heavy and light chains)By similarity
    Glycosylationi874 – 8741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi904 ↔ 909By similarity
    Glycosylationi945 – 9451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi973 – 9731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi980 – 9801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP80746.
    PRIDEiP80746.

    Interactioni

    Subunit structurei

    Interacts with RAB25. Interacts with CIB1 By similarity. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8. Alpha-V/beta-6 and alpha-V/beta-3 bind to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus.By similarity2 Publications

    Protein-protein interaction databases

    IntActiP80746. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP80746.
    SMRiP80746. Positions 31-986.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 992962ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1017 – 104832CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei993 – 101624HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati32 – 9867FG-GAP 1Add
    BLAST
    Repeati109 – 17062FG-GAP 2Add
    BLAST
    Repeati173 – 22553FG-GAP 3Add
    BLAST
    Repeati237 – 29559FG-GAP 4Add
    BLAST
    Repeati296 – 35762FG-GAP 5Add
    BLAST
    Repeati358 – 41558FG-GAP 6Add
    BLAST
    Repeati419 – 48264FG-GAP 7Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1019 – 10235GFFKR motif

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.Curated
    Contains 7 FG-GAP repeats.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26407.
    HOGENOMiHOG000231603.
    HOVERGENiHBG006186.
    KOiK06487.

    Family and domain databases

    InterProiIPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view]
    PfamiPF01839. FG-GAP. 2 hits.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 5 hits.
    [Graphical view]
    PROSITEiPS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80746-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFPPRRRLR LGPRGLPLLL SGLLLPLCRA FNLDVESPAE YSGPEGSYFG     50
    FAVDFFVPSA SSRMFLLVGA PKANTTQPGI VEGGQVLKCD WSSHRRCQPI 100
    EFDATGNRDY AKDDPLEFKS HQWFGASVRS KQDKILACAP LYHWRTEMKQ 150
    EREPVGTCFL QDGTKTVEYA PCRSKNIDAD GQGFCQGGFS IDFTKADRVL 200
    LGGPGSFYWQ GQLISDQVAE IVSKYDPKVY SIKYNNQLAT RTAQAIFDDS 250
    YLGYSVAVGD FNGDGIDDFV SGVPRAARTL GMVYIYDGKN MSSLHNFTGE 300
    QMAAYFGFSV AATDINGDDY ADVFIGAPLF MDRGSDGKLQ EVGQVSVSLQ 350
    KASGDFQTIK LNGFEVFARF GSAIAPLGDL DQDGFNDIAI AAPYGGEDKK 400
    GIVYIFNGRP TGLNAVPSQI LEGKWAARSM PPSFGYSMKG ATDIDKNGYP 450
    DLIVGAFGVD RAVLYRARPV ITVNAGLEVY PSILNQENKT CPLPGTDLKV 500
    SCFNVRFCLK ADGKGALPTK LDFQVELLLD KLKQKGAIRR ALFLHNRSPG 550
    HSKNMTISRG GQMQCEELIA YLRDESEFRD KLTPITIFME YWLDYRTAAD 600
    ATGLQPILNQ FTPANVSRQA HILLDCGEDN VCKPKLEVSV DSDQKKIYIG 650
    DDNPLTLIVK AQNQGEGAYE AELIVSIPLQ ADFIGVVRNS EALARLSCAF 700
    KTENQTRQVV CDLGNPMKAG TQLLAGLRFS VHQQSEMDTS VKFDLQIQSS 750
    NLFDKVSPVV SYKVDLAVLA AVEIRGVSSP DHIFLPIPNW KYKENPETEE 800
    DVGPVVQHIY ELRNNGPSSF SKAMLHLQWP YKYNNNTLLY ILQYDIDGPM 850
    NCTSDMEINP LRIKISNSQT SEKNDTVGGQ GDRNHLITKR DLTLNEGDVH 900
    TLGCGIAECL KIVCQVGRLD RGKSAILYVR SLLWTETFMN KENQNHSYSL 950
    KSSASFNVIE FPYKNLPIED IFNSTLVTTN VTWGIQPAPM PVPVWVIILA 1000
    VLAGLLLLAV LVFVMYRMGF FKRVRPPQEE QEREQLQPHE NGEGNSET 1048
    Length:1,048
    Mass (Da):116,132
    Last modified:January 23, 2007 - v3
    Checksum:iA6A5620EB3144502
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121G → R in ABH07896. 1 PublicationCurated
    Sequence conflicti15 – 173GLP → RLL in ABH07896. 1 PublicationCurated
    Sequence conflicti21 – 233SGL → PGI in ABH07896. 1 PublicationCurated
    Sequence conflicti29 – 291R → G in ABH07896. 1 PublicationCurated
    Sequence conflicti63 – 631Missing in AAF44691. (PubMed:10906183)Curated
    Sequence conflicti152 – 1521R → G in AAG38595. 1 PublicationCurated
    Sequence conflicti189 – 1891F → S in ABH07896. 1 PublicationCurated
    Sequence conflicti242 – 2421T → I in ABH07896. 1 PublicationCurated
    Sequence conflicti354 – 3541G → R in AAF44691. (PubMed:10906183)Curated
    Sequence conflicti415 – 4151A → T in AAF44691. (PubMed:10906183)Curated
    Sequence conflicti621 – 6211H → R in AAF44691. (PubMed:10906183)Curated
    Sequence conflicti629 – 6291D → G in AAF44691. (PubMed:10906183)Curated
    Sequence conflicti860 – 8601P → R in AAG38595. 1 PublicationCurated
    Sequence conflicti870 – 8701T → A in AAG38595. 1 PublicationCurated
    Sequence conflicti873 – 8731K → R in AAF44691. (PubMed:10906183)Curated
    Sequence conflicti894 – 8941L → V AA sequence (PubMed:9154926)Curated
    Sequence conflicti977 – 9771V → I in ABH07896. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF239958 mRNA. Translation: AAF44691.2.
    DQ871215 mRNA. Translation: ABH07896.1.
    AF317199 mRNA. Translation: AAG38595.1.
    RefSeqiNP_776792.1. NM_174367.1.
    UniGeneiBt.5273.

    Genome annotation databases

    GeneIDi281875.
    KEGGibta:281875.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF239958 mRNA. Translation: AAF44691.2 .
    DQ871215 mRNA. Translation: ABH07896.1 .
    AF317199 mRNA. Translation: AAG38595.1 .
    RefSeqi NP_776792.1. NM_174367.1.
    UniGenei Bt.5273.

    3D structure databases

    ProteinModelPortali P80746.
    SMRi P80746. Positions 31-986.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P80746. 1 interaction.

    Proteomic databases

    PaxDbi P80746.
    PRIDEi P80746.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 281875.
    KEGGi bta:281875.

    Organism-specific databases

    CTDi 3685.

    Phylogenomic databases

    eggNOGi NOG26407.
    HOGENOMi HOG000231603.
    HOVERGENi HBG006186.
    KOi K06487.

    Miscellaneous databases

    NextBioi 20805777.

    Family and domain databases

    InterProi IPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view ]
    Pfami PF01839. FG-GAP. 2 hits.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 5 hits.
    [Graphical view ]
    PROSITEi PS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency utilization of the bovine integrin alpha(v)beta(3) as a receptor for foot-and-mouth disease virus is dependent on the bovine beta(3) subunit."
      Neff S., Mason P.W., Baxt B.
      J. Virol. 74:7298-7306(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH FMDV CAPSID PROTEINS.
      Tissue: Lung.
    2. "Molecular cloning and characteristics of bovine alpha V cDNA."
      Du J., Chang H., Cong G., Shao J., Lin T., Liu Z., Liu X., Cai X., Xie Q.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    3. "Bovine alpha-V integrin subunit (fragment)."
      Andersen M.H., Rasmussen J.T., Berglund L., Petersen T.E.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-1048.
      Tissue: Mammary gland.
    4. "Bovine PAS-6/7 binds alpha v beta 5 integrins and anionic phospholipids through two domains."
      Andersen M.H., Berglund L., Rasmussen J.T., Petersen T.E.
      Biochemistry 36:5441-5446(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 31-50 AND 891-910.
      Tissue: Mammary gland.
    5. "Foot-and-mouth disease virus receptors: comparison of bovine alpha(V) integrin utilization by type A and O viruses."
      Duque H., Baxt B.
      J. Virol. 77:2500-2511(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HOST FMDV VP1.

    Entry informationi

    Entry nameiITAV_BOVIN
    AccessioniPrimary (citable) accession number: P80746
    Secondary accession number(s): Q0PDN6, Q9GK48, Q9MZD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3