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P80746

- ITAV_BOVIN

UniProt

P80746 - ITAV_BOVIN

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Protein
Integrin alpha-V
Gene
ITGAV
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The alpha-V integrins are receptors for vitronectin, MFGE8, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi260 – 2689 Reviewed prediction
Calcium bindingi314 – 3229 Reviewed prediction
Calcium bindingi379 – 3879 Reviewed prediction
Calcium bindingi443 – 4519 Reviewed prediction

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. virus receptor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. blood vessel development Source: AgBase
  2. cell adhesion Source: UniProtKB-KW
  3. integrin-mediated signaling pathway Source: UniProtKB-KW
  4. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Integrin, Receptor

Keywords - Biological processi

Cell adhesion, Host-virus interaction

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-V
Alternative name(s):
Vitronectin receptor subunit alpha
CD_antigen: CD51
Cleaved into the following 2 chains:
Gene namesi
Name:ITGAV
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 992962Extracellular Reviewed prediction
Add
BLAST
Transmembranei993 – 101624Helical; Reviewed prediction
Add
BLAST
Topological domaini1017 – 104832Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 30301 Publication
Add
BLAST
Chaini31 – 10481018Integrin alpha-V
PRO_0000016298Add
BLAST
Chaini31 – 889859Integrin alpha-V heavy chain
PRO_0000016299Add
BLAST
Chaini891 – 1048158Integrin alpha-V light chain
PRO_0000016300Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi89 ↔ 97 By similarity
Disulfide bondi138 ↔ 158 By similarity
Disulfide bondi172 ↔ 185 By similarity
Glycosylationi290 – 2901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi296 – 2961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi488 – 4881N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi491 ↔ 502 By similarity
Disulfide bondi508 ↔ 565 By similarity
Glycosylationi554 – 5541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi615 – 6151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi626 ↔ 632 By similarity
Disulfide bondi698 ↔ 711 By similarity
Glycosylationi704 – 7041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi835 – 8351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi851 – 8511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi852 ↔ 914Interchain (between heavy and light chains) By similarity
Glycosylationi874 – 8741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi904 ↔ 909 By similarity
Glycosylationi945 – 9451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi973 – 9731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi980 – 9801N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP80746.
PRIDEiP80746.

Interactioni

Subunit structurei

Interacts with RAB25. Interacts with CIB1 By similarity. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8. Alpha-V/beta-6 and alpha-V/beta-3 bind to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus.2 Publications

Protein-protein interaction databases

IntActiP80746. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP80746.
SMRiP80746. Positions 31-986.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati32 – 9867FG-GAP 1
Add
BLAST
Repeati109 – 17062FG-GAP 2
Add
BLAST
Repeati173 – 22553FG-GAP 3
Add
BLAST
Repeati237 – 29559FG-GAP 4
Add
BLAST
Repeati296 – 35762FG-GAP 5
Add
BLAST
Repeati358 – 41558FG-GAP 6
Add
BLAST
Repeati419 – 48264FG-GAP 7
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1019 – 10235GFFKR motif

Sequence similaritiesi

Contains 7 FG-GAP repeats.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26407.
HOGENOMiHOG000231603.
HOVERGENiHBG006186.
KOiK06487.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80746-1 [UniParc]FASTAAdd to Basket

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MAFPPRRRLR LGPRGLPLLL SGLLLPLCRA FNLDVESPAE YSGPEGSYFG     50
FAVDFFVPSA SSRMFLLVGA PKANTTQPGI VEGGQVLKCD WSSHRRCQPI 100
EFDATGNRDY AKDDPLEFKS HQWFGASVRS KQDKILACAP LYHWRTEMKQ 150
EREPVGTCFL QDGTKTVEYA PCRSKNIDAD GQGFCQGGFS IDFTKADRVL 200
LGGPGSFYWQ GQLISDQVAE IVSKYDPKVY SIKYNNQLAT RTAQAIFDDS 250
YLGYSVAVGD FNGDGIDDFV SGVPRAARTL GMVYIYDGKN MSSLHNFTGE 300
QMAAYFGFSV AATDINGDDY ADVFIGAPLF MDRGSDGKLQ EVGQVSVSLQ 350
KASGDFQTIK LNGFEVFARF GSAIAPLGDL DQDGFNDIAI AAPYGGEDKK 400
GIVYIFNGRP TGLNAVPSQI LEGKWAARSM PPSFGYSMKG ATDIDKNGYP 450
DLIVGAFGVD RAVLYRARPV ITVNAGLEVY PSILNQENKT CPLPGTDLKV 500
SCFNVRFCLK ADGKGALPTK LDFQVELLLD KLKQKGAIRR ALFLHNRSPG 550
HSKNMTISRG GQMQCEELIA YLRDESEFRD KLTPITIFME YWLDYRTAAD 600
ATGLQPILNQ FTPANVSRQA HILLDCGEDN VCKPKLEVSV DSDQKKIYIG 650
DDNPLTLIVK AQNQGEGAYE AELIVSIPLQ ADFIGVVRNS EALARLSCAF 700
KTENQTRQVV CDLGNPMKAG TQLLAGLRFS VHQQSEMDTS VKFDLQIQSS 750
NLFDKVSPVV SYKVDLAVLA AVEIRGVSSP DHIFLPIPNW KYKENPETEE 800
DVGPVVQHIY ELRNNGPSSF SKAMLHLQWP YKYNNNTLLY ILQYDIDGPM 850
NCTSDMEINP LRIKISNSQT SEKNDTVGGQ GDRNHLITKR DLTLNEGDVH 900
TLGCGIAECL KIVCQVGRLD RGKSAILYVR SLLWTETFMN KENQNHSYSL 950
KSSASFNVIE FPYKNLPIED IFNSTLVTTN VTWGIQPAPM PVPVWVIILA 1000
VLAGLLLLAV LVFVMYRMGF FKRVRPPQEE QEREQLQPHE NGEGNSET 1048
Length:1,048
Mass (Da):116,132
Last modified:January 23, 2007 - v3
Checksum:iA6A5620EB3144502
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121G → R in ABH07896. 1 Publication
Sequence conflicti15 – 173GLP → RLL in ABH07896. 1 Publication
Sequence conflicti21 – 233SGL → PGI in ABH07896. 1 Publication
Sequence conflicti29 – 291R → G in ABH07896. 1 Publication
Sequence conflicti63 – 631Missing in AAF44691. 1 Publication
Sequence conflicti152 – 1521R → G in AAG38595. 1 Publication
Sequence conflicti189 – 1891F → S in ABH07896. 1 Publication
Sequence conflicti242 – 2421T → I in ABH07896. 1 Publication
Sequence conflicti354 – 3541G → R in AAF44691. 1 Publication
Sequence conflicti415 – 4151A → T in AAF44691. 1 Publication
Sequence conflicti621 – 6211H → R in AAF44691. 1 Publication
Sequence conflicti629 – 6291D → G in AAF44691. 1 Publication
Sequence conflicti860 – 8601P → R in AAG38595. 1 Publication
Sequence conflicti870 – 8701T → A in AAG38595. 1 Publication
Sequence conflicti873 – 8731K → R in AAF44691. 1 Publication
Sequence conflicti894 – 8941L → V AA sequence 1 Publication
Sequence conflicti977 – 9771V → I in ABH07896. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF239958 mRNA. Translation: AAF44691.2.
DQ871215 mRNA. Translation: ABH07896.1.
AF317199 mRNA. Translation: AAG38595.1.
RefSeqiNP_776792.1. NM_174367.1.
UniGeneiBt.5273.

Genome annotation databases

GeneIDi281875.
KEGGibta:281875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF239958 mRNA. Translation: AAF44691.2 .
DQ871215 mRNA. Translation: ABH07896.1 .
AF317199 mRNA. Translation: AAG38595.1 .
RefSeqi NP_776792.1. NM_174367.1.
UniGenei Bt.5273.

3D structure databases

ProteinModelPortali P80746.
SMRi P80746. Positions 31-986.
ModBasei Search...

Protein-protein interaction databases

IntActi P80746. 1 interaction.

Proteomic databases

PaxDbi P80746.
PRIDEi P80746.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281875.
KEGGi bta:281875.

Organism-specific databases

CTDi 3685.

Phylogenomic databases

eggNOGi NOG26407.
HOGENOMi HOG000231603.
HOVERGENi HBG006186.
KOi K06487.

Miscellaneous databases

NextBioi 20805777.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view ]
Pfami PF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
[Graphical view ]
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency utilization of the bovine integrin alpha(v)beta(3) as a receptor for foot-and-mouth disease virus is dependent on the bovine beta(3) subunit."
    Neff S., Mason P.W., Baxt B.
    J. Virol. 74:7298-7306(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH FMDV CAPSID PROTEINS.
    Tissue: Lung.
  2. "Molecular cloning and characteristics of bovine alpha V cDNA."
    Du J., Chang H., Cong G., Shao J., Lin T., Liu Z., Liu X., Cai X., Xie Q.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  3. "Bovine alpha-V integrin subunit (fragment)."
    Andersen M.H., Rasmussen J.T., Berglund L., Petersen T.E.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-1048.
    Tissue: Mammary gland.
  4. "Bovine PAS-6/7 binds alpha v beta 5 integrins and anionic phospholipids through two domains."
    Andersen M.H., Berglund L., Rasmussen J.T., Petersen T.E.
    Biochemistry 36:5441-5446(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 31-50 AND 891-910.
    Tissue: Mammary gland.
  5. "Foot-and-mouth disease virus receptors: comparison of bovine alpha(V) integrin utilization by type A and O viruses."
    Duque H., Baxt B.
    J. Virol. 77:2500-2511(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOST FMDV VP1.

Entry informationi

Entry nameiITAV_BOVIN
AccessioniPrimary (citable) accession number: P80746
Secondary accession number(s): Q0PDN6, Q9GK48, Q9MZD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3
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