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P80746 (ITAV_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Integrin alpha-V
Alternative name(s):
Vitronectin receptor subunit alpha
CD_antigen=CD51

Cleaved into the following 2 chains:

  1. Integrin alpha-V heavy chain
  2. Integrin alpha-V light chain
Gene names
Name:ITGAV
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length1048 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The alpha-V integrins are receptors for vitronectin, MFGE8, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands.

Subunit structure

Interacts with RAB25 By similarity. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8. Alpha-V/beta-6 and alpha-V/beta-3 bind to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus. Ref.1 Ref.5

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the integrin alpha chain family.

Contains 7 FG-GAP repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Ref.4
Chain31 – 10481018Integrin alpha-V
PRO_0000016298
Chain31 – 889859Integrin alpha-V heavy chain
PRO_0000016299
Chain891 – 1048158Integrin alpha-V light chain
PRO_0000016300

Regions

Topological domain31 – 992962Extracellular Potential
Transmembrane993 – 101624Helical; Potential
Topological domain1017 – 104832Cytoplasmic Potential
Repeat32 – 9867FG-GAP 1
Repeat109 – 17062FG-GAP 2
Repeat173 – 22553FG-GAP 3
Repeat237 – 29559FG-GAP 4
Repeat296 – 35762FG-GAP 5
Repeat358 – 41558FG-GAP 6
Repeat419 – 48264FG-GAP 7
Calcium binding260 – 2689 Potential
Calcium binding314 – 3229 Potential
Calcium binding379 – 3879 Potential
Calcium binding443 – 4519 Potential
Motif1019 – 10235GFFKR motif

Amino acid modifications

Glycosylation741N-linked (GlcNAc...) Potential
Glycosylation2901N-linked (GlcNAc...) Potential
Glycosylation2961N-linked (GlcNAc...) Potential
Glycosylation4881N-linked (GlcNAc...) Potential
Glycosylation5541N-linked (GlcNAc...) Potential
Glycosylation6151N-linked (GlcNAc...) Potential
Glycosylation7041N-linked (GlcNAc...) Potential
Glycosylation8351N-linked (GlcNAc...) Potential
Glycosylation8511N-linked (GlcNAc...) Potential
Glycosylation8741N-linked (GlcNAc...) Potential
Glycosylation9451N-linked (GlcNAc...) Potential
Glycosylation9731N-linked (GlcNAc...) Potential
Glycosylation9801N-linked (GlcNAc...) Potential
Disulfide bond89 ↔ 97 By similarity
Disulfide bond138 ↔ 158 By similarity
Disulfide bond172 ↔ 185 By similarity
Disulfide bond491 ↔ 502 By similarity
Disulfide bond508 ↔ 565 By similarity
Disulfide bond626 ↔ 632 By similarity
Disulfide bond698 ↔ 711 By similarity
Disulfide bond852 ↔ 914Interchain (between heavy and light chains) By similarity
Disulfide bond904 ↔ 909 By similarity

Experimental info

Sequence conflict121G → R in ABH07896. Ref.2
Sequence conflict15 – 173GLP → RLL in ABH07896. Ref.2
Sequence conflict21 – 233SGL → PGI in ABH07896. Ref.2
Sequence conflict291R → G in ABH07896. Ref.2
Sequence conflict631Missing in AAF44691. Ref.1
Sequence conflict1521R → G in AAG38595. Ref.3
Sequence conflict1891F → S in ABH07896. Ref.2
Sequence conflict2421T → I in ABH07896. Ref.2
Sequence conflict3541G → R in AAF44691. Ref.1
Sequence conflict4151A → T in AAF44691. Ref.1
Sequence conflict6211H → R in AAF44691. Ref.1
Sequence conflict6291D → G in AAF44691. Ref.1
Sequence conflict8601P → R in AAG38595. Ref.3
Sequence conflict8701T → A in AAG38595. Ref.3
Sequence conflict8731K → R in AAF44691. Ref.1
Sequence conflict8941L → V AA sequence Ref.4
Sequence conflict9771V → I in ABH07896. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P80746 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: A6A5620EB3144502

FASTA1,048116,132
        10         20         30         40         50         60 
MAFPPRRRLR LGPRGLPLLL SGLLLPLCRA FNLDVESPAE YSGPEGSYFG FAVDFFVPSA 

        70         80         90        100        110        120 
SSRMFLLVGA PKANTTQPGI VEGGQVLKCD WSSHRRCQPI EFDATGNRDY AKDDPLEFKS 

       130        140        150        160        170        180 
HQWFGASVRS KQDKILACAP LYHWRTEMKQ EREPVGTCFL QDGTKTVEYA PCRSKNIDAD 

       190        200        210        220        230        240 
GQGFCQGGFS IDFTKADRVL LGGPGSFYWQ GQLISDQVAE IVSKYDPKVY SIKYNNQLAT 

       250        260        270        280        290        300 
RTAQAIFDDS YLGYSVAVGD FNGDGIDDFV SGVPRAARTL GMVYIYDGKN MSSLHNFTGE 

       310        320        330        340        350        360 
QMAAYFGFSV AATDINGDDY ADVFIGAPLF MDRGSDGKLQ EVGQVSVSLQ KASGDFQTIK 

       370        380        390        400        410        420 
LNGFEVFARF GSAIAPLGDL DQDGFNDIAI AAPYGGEDKK GIVYIFNGRP TGLNAVPSQI 

       430        440        450        460        470        480 
LEGKWAARSM PPSFGYSMKG ATDIDKNGYP DLIVGAFGVD RAVLYRARPV ITVNAGLEVY 

       490        500        510        520        530        540 
PSILNQENKT CPLPGTDLKV SCFNVRFCLK ADGKGALPTK LDFQVELLLD KLKQKGAIRR 

       550        560        570        580        590        600 
ALFLHNRSPG HSKNMTISRG GQMQCEELIA YLRDESEFRD KLTPITIFME YWLDYRTAAD 

       610        620        630        640        650        660 
ATGLQPILNQ FTPANVSRQA HILLDCGEDN VCKPKLEVSV DSDQKKIYIG DDNPLTLIVK 

       670        680        690        700        710        720 
AQNQGEGAYE AELIVSIPLQ ADFIGVVRNS EALARLSCAF KTENQTRQVV CDLGNPMKAG 

       730        740        750        760        770        780 
TQLLAGLRFS VHQQSEMDTS VKFDLQIQSS NLFDKVSPVV SYKVDLAVLA AVEIRGVSSP 

       790        800        810        820        830        840 
DHIFLPIPNW KYKENPETEE DVGPVVQHIY ELRNNGPSSF SKAMLHLQWP YKYNNNTLLY 

       850        860        870        880        890        900 
ILQYDIDGPM NCTSDMEINP LRIKISNSQT SEKNDTVGGQ GDRNHLITKR DLTLNEGDVH 

       910        920        930        940        950        960 
TLGCGIAECL KIVCQVGRLD RGKSAILYVR SLLWTETFMN KENQNHSYSL KSSASFNVIE 

       970        980        990       1000       1010       1020 
FPYKNLPIED IFNSTLVTTN VTWGIQPAPM PVPVWVIILA VLAGLLLLAV LVFVMYRMGF 

      1030       1040 
FKRVRPPQEE QEREQLQPHE NGEGNSET

« Hide

References

[1]"High-efficiency utilization of the bovine integrin alpha(v)beta(3) as a receptor for foot-and-mouth disease virus is dependent on the bovine beta(3) subunit."
Neff S., Mason P.W., Baxt B.
J. Virol. 74:7298-7306(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH FMDV CAPSID PROTEINS.
Tissue: Lung.
[2]"Molecular cloning and characteristics of bovine alpha V cDNA."
Du J., Chang H., Cong G., Shao J., Lin T., Liu Z., Liu X., Cai X., Xie Q.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[3]"Bovine alpha-V integrin subunit (fragment)."
Andersen M.H., Rasmussen J.T., Berglund L., Petersen T.E.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-1048.
Tissue: Mammary gland.
[4]"Bovine PAS-6/7 binds alpha v beta 5 integrins and anionic phospholipids through two domains."
Andersen M.H., Berglund L., Rasmussen J.T., Petersen T.E.
Biochemistry 36:5441-5446(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 31-50 AND 891-910.
Tissue: Mammary gland.
[5]"Foot-and-mouth disease virus receptors: comparison of bovine alpha(V) integrin utilization by type A and O viruses."
Duque H., Baxt B.
J. Virol. 77:2500-2511(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HOST FMDV VP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF239958 mRNA. Translation: AAF44691.2.
DQ871215 mRNA. Translation: ABH07896.1.
AF317199 mRNA. Translation: AAG38595.1.
IPIIPI00707643.
RefSeqNP_776792.1. NM_174367.1.
UniGeneBt.5273.

3D structure databases

ProteinModelPortalP80746.
SMRP80746. Positions 31-986.
ModBaseSearch...

Protein-protein interaction databases

IntActP80746. 1 interaction.

Proteomic databases

PaxDbP80746.
PRIDEP80746.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID281875.
KEGGbta:281875.

Organism-specific databases

CTD3685.

Phylogenomic databases

eggNOGNOG26407.
HOGENOMHOG000231603.
HOVERGENHBG006186.
KOK06487.

Family and domain databases

InterProIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamPF01839. FG-GAP. 3 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805777.

Entry information

Entry nameITAV_BOVIN
AccessionPrimary (citable) accession number: P80746
Secondary accession number(s): Q0PDN6, Q9GK48, Q9MZD6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents