P80740 (ALL5A_OLEEU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Superoxide dismutase [Cu-Zn] 1 EC=1.15.1.1 Alternative name(s): Allergen Ole e V Allergen=Ole e 5
Organism	Olea europaea (Common olive)
Taxonomic identifier	4146 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Lamiales › Oleaceae › Oleeae › Olea

Protein attributes

Sequence length	30 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Probably involved in the protection against oxidative stress during pollen development. Ref.2
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Enzyme regulation	Inhibited by KCN and H2O2. Ref.2
Subcellular location	Cytoplasm. Endoplasmic reticulum Ref.2.
Tissue specificity	Expressed in fruits, leaves and pollen grains. Ref.2 Ref.3 Ref.4
Polymorphism	Several isoforms of the allergen exist due to polymorphism.
Allergenic properties	Causes an allergic reaction in human. Allergen from olive pollen. Important in Mediterranean countries and California. Its prevalence is related to the geographic area.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Cellular component	Cytoplasm Endoplasmic reticulum
Disease	Allergen
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – ›30	›29	Superoxide dismutase [Cu-Zn] 1		PRO_0000164147
Experimental info
	Non-terminal residue	30	1

Sequences

	Sequence		Length	Mass (Da)
	P80740 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 836C7A193E930383	FASTA	30	3,104
	10 20 30 MVKAVTVLNS SEGPHGIVYF AQEGDGPTTV

References

[1]	"Purification, characterization, and partial sequencing of two new allergens of Olea europaea." Boluda L., Alonso C., Fernandez-Caldas E. J. Allergy Clin. Immunol. 101:210-216(1998) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-30. Tissue: Pollen.
[2]	"Identification and immunolocalization of superoxide dismutase isoenzymes of olive pollen." Alche J.D., Corpas F.J., Rodriguez-Garcia M.I., del Rio L.A. Physiol. Plantarum 104:772-776(1998) Cited for: FUNCTION, SUBCELLULAR LOCATION, ENZYME REGULATION, TISSUE SPECIFICITY.
[3]	"The expression of different superoxide dismutase forms is cell-type dependent in olive (Olea europaea L.) leaves." Corpas F.J., Fernandez-Ocana A., Carreras A., Valderrama R., Luque F., Esteban F.J., Rodriguez-Serrano M., Chaki M., Pedrajas J.R., Sandalio L.M., del Rio L.A., Barroso J.B. Plant Cell Physiol. 47:984-994(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[4]	"Identification of olive (Olea europaea) pulp proteins by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and nano-liquid chromatography tandem mass spectrometry." Esteve C., Canas B., Moreno-Gordaliza E., Del Rio C., Garcia M.C., Marina M.L. J. Agric. Food Chem. 59:12093-12101(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY.
[5]	"Analysis of olive allergens." Esteve C., Montealegre C., Marina M.L., Garcia M.C. Talanta 92:1-14(2012) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW, NOMENCLATURE.

Cross-references

3D structure databases
ModBase	Search...
Protein family/group databases
Allergome	3386. Ole e 5.0101. 493. Ole e 5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
PROSITE	PS00087. SOD_CU_ZN_1. Partial match. PS00332. SOD_CU_ZN_2. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALL5A_OLEEU

Accession

Primary (citable) accession number: P80740

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program