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P80735

- SODN_STRCO

UniProt

P80735 - SODN_STRCO

Protein

Superoxide dismutase [Ni]

Gene

sodN

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Nickel.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi15 – 151Nickel; catalytic
    Metal bindingi16 – 161Nickel; catalytic
    Metal bindingi20 – 201Nickel; catalytic

    GO - Molecular functioni

    1. nickel cation binding Source: InterPro
    2. superoxide dismutase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Antioxidant, Oxidoreductase

    Keywords - Ligandi

    Metal-binding, Nickel

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Ni] (EC:1.15.1.1)
    Alternative name(s):
    NiSOD
    Nickel-containing superoxide dismutase
    Gene namesi
    Name:sodN
    Synonyms:sod1
    Ordered Locus Names:SCO5254
    ORF Names:2SC7G11.16c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 14142 PublicationsPRO_0000032906Add
    BLAST
    Chaini15 – 131117Superoxide dismutase [Ni]PRO_0000032907Add
    BLAST

    Proteomic databases

    PRIDEiP80735.

    Interactioni

    Subunit structurei

    Homohexamer. The hexameric protein has a roughly the shape of a hollow sphere with an outer diameter of 60 angstroms and a large interior cavity.1 Publication

    Protein-protein interaction databases

    STRINGi100226.SCO5254.

    Structurei

    Secondary structure

    1
    131
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi17 – 193
    Helixi26 – 4419
    Helixi48 – 7528
    Helixi79 – 846
    Helixi88 – 10316
    Helixi108 – 12821

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1T6IX-ray2.81A/B/C15-131[»]
    1T6QX-ray2.05A/B/C15-131[»]
    1T6UX-ray1.30A/B/C/D/E/F/G/H/I/J/K/L15-131[»]
    3G4XX-ray2.01A/B/C15-131[»]
    3G4ZX-ray1.87A/B/C15-131[»]
    3G50X-ray1.90A/B/C15-131[»]
    ProteinModelPortaliP80735.
    SMRiP80735. Positions 15-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP80735.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nickel superoxide dismutase family.Curated

    Phylogenomic databases

    eggNOGiNOG39351.
    HOGENOMiHOG000020289.
    KOiK00518.
    OMAiEHLATFP.
    OrthoDBiEOG683S9W.

    Family and domain databases

    Gene3Di1.20.120.400. 1 hit.
    InterProiIPR014123. Superoxide_dismutase_Ni-type.
    [Graphical view]
    PfamiPF09055. Sod_Ni. 1 hit.
    [Graphical view]
    SUPFAMiSSF109770. SSF109770. 1 hit.
    TIGRFAMsiTIGR02753. sodN. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80735-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSRLFAPKV TVSAHCDLPC GVYDPAQARI EAESVKAVQE KMAGNDDPHF    50
    QTRATVIKEQ RAELAKHHVS VLWSDYFKPP HFEKYPELHQ LVNDTLKALS 100
    AAKGSKDPAT GQKALDYIAQ IDKIFWETKK A 131
    Length:131
    Mass (Da):14,703
    Last modified:December 1, 2000 - v2
    Checksum:i8DA21AFBAC0D7EF6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161C → G AA sequence (PubMed:8836134)Curated
    Sequence conflicti16 – 161C → G AA sequence (PubMed:8898904)Curated
    Sequence conflicti20 – 201C → G AA sequence (PubMed:8836134)Curated
    Sequence conflicti20 – 201C → G AA sequence (PubMed:8898904)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF012193 Genomic DNA. Translation: AAC38082.1.
    AF104994 Genomic DNA. Translation: AAF25537.1.
    AL939123 Genomic DNA. Translation: CAC05965.1.
    RefSeqiNP_629400.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAC05965; CAC05965; CAC05965.
    GeneIDi1100695.
    KEGGisco:SCO5254.
    PATRICi23740360. VBIStrCoe124346_5338.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF012193 Genomic DNA. Translation: AAC38082.1 .
    AF104994 Genomic DNA. Translation: AAF25537.1 .
    AL939123 Genomic DNA. Translation: CAC05965.1 .
    RefSeqi NP_629400.1. NC_003888.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1T6I X-ray 2.81 A/B/C 15-131 [» ]
    1T6Q X-ray 2.05 A/B/C 15-131 [» ]
    1T6U X-ray 1.30 A/B/C/D/E/F/G/H/I/J/K/L 15-131 [» ]
    3G4X X-ray 2.01 A/B/C 15-131 [» ]
    3G4Z X-ray 1.87 A/B/C 15-131 [» ]
    3G50 X-ray 1.90 A/B/C 15-131 [» ]
    ProteinModelPortali P80735.
    SMRi P80735. Positions 15-131.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO5254.

    Proteomic databases

    PRIDEi P80735.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC05965 ; CAC05965 ; CAC05965 .
    GeneIDi 1100695.
    KEGGi sco:SCO5254.
    PATRICi 23740360. VBIStrCoe124346_5338.

    Phylogenomic databases

    eggNOGi NOG39351.
    HOGENOMi HOG000020289.
    KOi K00518.
    OMAi EHLATFP.
    OrthoDBi EOG683S9W.

    Miscellaneous databases

    EvolutionaryTracei P80735.

    Family and domain databases

    Gene3Di 1.20.120.400. 1 hit.
    InterProi IPR014123. Superoxide_dismutase_Ni-type.
    [Graphical view ]
    Pfami PF09055. Sod_Ni. 1 hit.
    [Graphical view ]
    SUPFAMi SSF109770. SSF109770. 1 hit.
    TIGRFAMsi TIGR02753. sodN. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Transcriptional and post-transcriptional regulation by nickel of sodN gene encoding nickel-containing superoxide dismutase from Streptomyces coelicolor Muller."
      Kim E.-J., Chung H.-J., Suh B., Hah Y.C., Roe J.-H.
      Mol. Microbiol. 27:187-195(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 10147 / DSM 41007 / JCM 4020 / NBRC 3176 / KCC S-0020 and ATCC BAA-471 / A3(2) / M145.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.
    3. "A novel nickel-containing superoxide dismutase from Streptomyces spp."
      Youn H.-D., Kim E.-J., Roe J.-H., Hah Y.C., Kang S.-O.
      Biochem. J. 318:889-896(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 15-28.
      Strain: ATCC 10147 / DSM 41007 / JCM 4020 / NBRC 3176 / KCC S-0020.
    4. "Differential expression of superoxide dismutases containing Ni and Fe/Zn in Streptomyces coelicolor."
      Kim F.-J., Kim H.-P., Hah Y.V., Roe J.-H.
      Eur. J. Biochem. 241:178-185(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 15-28.
      Strain: ATCC 10147 / DSM 41007 / JCM 4020 / NBRC 3176 / KCC S-0020.
    5. Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 15-131 IN COMPLEX WITH NICKEL IONS, SUBUNIT.

    Entry informationi

    Entry nameiSODN_STRCO
    AccessioniPrimary (citable) accession number: P80735
    Secondary accession number(s): O51921
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3