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P80734

- SODN_STRSO

UniProt

P80734 - SODN_STRSO

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Protein

Superoxide dismutase [Ni]

Gene

sodN

Organism
Streptomyces seoulensis
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Nickel.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi15 – 151Nickel; catalytic
Metal bindingi16 – 161Nickel; catalytic
Metal bindingi20 – 201Nickel; catalytic

GO - Molecular functioni

  1. nickel cation binding Source: InterPro
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Metal-binding, Nickel

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Ni] (EC:1.15.1.1)
Alternative name(s):
NiSOD
Nickel-containing superoxide dismutase
Gene namesi
Name:sodN
OrganismiStreptomyces seoulensis
Taxonomic identifieri73044 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi15 – 151H → A, C, D, K, N, Q, R, W or Y: Loss of activity. 1 Publication
Mutagenesisi23 – 231Y → A, K or Q: Loss of activity. 1 Publication
Mutagenesisi23 – 231Y → F or W: Slight decrease of activity. 1 Publication
Mutagenesisi31 – 311E → A: Loss of activity. 1 Publication
Mutagenesisi53 – 531R → A: Loss of activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 14141 PublicationPRO_0000032908Add
BLAST
Chaini15 – 131117Superoxide dismutase [Ni]PRO_0000032909Add
BLAST

Interactioni

Subunit structurei

Homohexamer. The hexameric protein has roughly the shape of a hollow sphere with an outer diameter of 72 Angstroms and a large inner cavity.1 Publication

Structurei

Secondary structure

1
131
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 4419
Helixi48 – 7427
Helixi79 – 846
Helixi88 – 10316
Helixi108 – 13023

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q0DX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L15-131[»]
1Q0FX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L15-131[»]
1Q0GX-ray1.60A/B/C/D/E/F/G/H/I/J/K/L15-131[»]
1Q0KX-ray2.10A/B/C/D/E/F/G/H/I/J/K/L15-131[»]
1Q0MX-ray1.68A/B/C/D/E/F15-131[»]
ProteinModelPortaliP80734.
SMRiP80734. Positions 15-131.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80734.

Family & Domainsi

Sequence similaritiesi

Belongs to the nickel superoxide dismutase family.Curated

Family and domain databases

Gene3Di1.20.120.400. 1 hit.
InterProiIPR014123. Superoxide_dismutase_Ni-type.
[Graphical view]
PfamiPF09055. Sod_Ni. 1 hit.
[Graphical view]
SUPFAMiSSF109770. SSF109770. 1 hit.
TIGRFAMsiTIGR02753. sodN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80734 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSRLFAPKV KVSAHCDLPC GVYDPAQARI EAESVKAIQE KMAANDDLHF
60 70 80 90 100
QIRATVIKEQ RAELAKHHLD VLWSDYFKPP HFESYPELHT LVNEAVKALS
110 120 130
AAKASTDPAT GQKALDYIAQ IDKIFWETKK A
Length:131
Mass (Da):14,717
Last modified:December 1, 2000 - v2
Checksum:iDD5467214689478C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161C → G AA sequence (PubMed:8836134)Curated
Sequence conflicti20 – 201C → G AA sequence (PubMed:8836134)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047528 Genomic DNA. Translation: AAD17486.1.
AF047461 Genomic DNA. Translation: AAD17482.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047528 Genomic DNA. Translation: AAD17486.1 .
AF047461 Genomic DNA. Translation: AAD17482.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Q0D X-ray 2.20 A/B/C/D/E/F/G/H/I/J/K/L 15-131 [» ]
1Q0F X-ray 2.20 A/B/C/D/E/F/G/H/I/J/K/L 15-131 [» ]
1Q0G X-ray 1.60 A/B/C/D/E/F/G/H/I/J/K/L 15-131 [» ]
1Q0K X-ray 2.10 A/B/C/D/E/F/G/H/I/J/K/L 15-131 [» ]
1Q0M X-ray 1.68 A/B/C/D/E/F 15-131 [» ]
ProteinModelPortali P80734.
SMRi P80734. Positions 15-131.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P80734.

Family and domain databases

Gene3Di 1.20.120.400. 1 hit.
InterProi IPR014123. Superoxide_dismutase_Ni-type.
[Graphical view ]
Pfami PF09055. Sod_Ni. 1 hit.
[Graphical view ]
SUPFAMi SSF109770. SSF109770. 1 hit.
TIGRFAMsi TIGR02753. sodN. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of sodN encoding Ni-containing superoxide dismutase from Streptomyces seoulensis."
    Kang S.-O., Yim Y.I., Youn H.-D.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: IMSNU-1.
  2. "A novel nickel-containing superoxide dismutase from Streptomyces spp."
    Youn H.-D., Kim E.-J., Roe J.-H., Hah Y.C., Kang S.-O.
    Biochem. J. 318:889-896(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 15-28.
    Strain: IMSNU-1.
  3. "Crystal structure of nickel-containing superoxide dismutase reveals another type of active site."
    Wuerges J., Lee J.W., Yim Y.I., Yim H.S., Kang S.O., Carugo K.D.
    Proc. Natl. Acad. Sci. U.S.A. 101:8569-8574(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 15-131 IN COMPLEX WITH NICKEL IONS, MUTAGENESIS OF HIS-15; TYR-23; GLU-31 AND ARG-53, SUBUNIT.

Entry informationi

Entry nameiSODN_STRSO
AccessioniPrimary (citable) accession number: P80734
Secondary accession number(s): Q9Z368
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3