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Protein

Superoxide dismutase [Ni]

Gene

sodN

Organism
Streptomyces seoulensis
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi15Nickel; catalytic1
Metal bindingi16Nickel; catalytic1
Metal bindingi20Nickel; catalytic1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Metal-binding, Nickel

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Ni] (EC:1.15.1.1)
Alternative name(s):
NiSOD
Nickel-containing superoxide dismutase
Gene namesi
Name:sodN
OrganismiStreptomyces seoulensis
Taxonomic identifieri73044 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi15H → A, C, D, K, N, Q, R, W or Y: Loss of activity. 1 Publication1
Mutagenesisi23Y → A, K or Q: Loss of activity. 1 Publication1
Mutagenesisi23Y → F or W: Slight decrease of activity. 1 Publication1
Mutagenesisi31E → A: Loss of activity. 1 Publication1
Mutagenesisi53R → A: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000329081 – 141 PublicationAdd BLAST14
ChainiPRO_000003290915 – 131Superoxide dismutase [Ni]Add BLAST117

Interactioni

Subunit structurei

Homohexamer. The hexameric protein has roughly the shape of a hollow sphere with an outer diameter of 72 Angstroms and a large inner cavity.1 Publication

Structurei

Secondary structure

1131
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 44Combined sources19
Helixi48 – 74Combined sources27
Helixi79 – 84Combined sources6
Helixi88 – 103Combined sources16
Helixi108 – 130Combined sources23

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q0DX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L15-131[»]
1Q0FX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L15-131[»]
1Q0GX-ray1.60A/B/C/D/E/F/G/H/I/J/K/L15-131[»]
1Q0KX-ray2.10A/B/C/D/E/F/G/H/I/J/K/L15-131[»]
1Q0MX-ray1.68A/B/C/D/E/F15-131[»]
ProteinModelPortaliP80734.
SMRiP80734.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80734.

Family & Domainsi

Sequence similaritiesi

Belongs to the nickel superoxide dismutase family.Curated

Family and domain databases

Gene3Di1.20.120.400. 1 hit.
InterProiIPR014123. Superoxide_dismutase_Ni-type.
[Graphical view]
PfamiPF09055. Sod_Ni. 1 hit.
[Graphical view]
SUPFAMiSSF109770. SSF109770. 1 hit.
TIGRFAMsiTIGR02753. sodN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRLFAPKV KVSAHCDLPC GVYDPAQARI EAESVKAIQE KMAANDDLHF
60 70 80 90 100
QIRATVIKEQ RAELAKHHLD VLWSDYFKPP HFESYPELHT LVNEAVKALS
110 120 130
AAKASTDPAT GQKALDYIAQ IDKIFWETKK A
Length:131
Mass (Da):14,717
Last modified:December 1, 2000 - v2
Checksum:iDD5467214689478C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16C → G AA sequence (PubMed:8836134).Curated1
Sequence conflicti20C → G AA sequence (PubMed:8836134).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047528 Genomic DNA. Translation: AAD17486.1.
AF047461 Genomic DNA. Translation: AAD17482.1.
RefSeqiWP_031181160.1. NZ_JNXP01000009.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047528 Genomic DNA. Translation: AAD17486.1.
AF047461 Genomic DNA. Translation: AAD17482.1.
RefSeqiWP_031181160.1. NZ_JNXP01000009.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q0DX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L15-131[»]
1Q0FX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L15-131[»]
1Q0GX-ray1.60A/B/C/D/E/F/G/H/I/J/K/L15-131[»]
1Q0KX-ray2.10A/B/C/D/E/F/G/H/I/J/K/L15-131[»]
1Q0MX-ray1.68A/B/C/D/E/F15-131[»]
ProteinModelPortaliP80734.
SMRiP80734.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP80734.

Family and domain databases

Gene3Di1.20.120.400. 1 hit.
InterProiIPR014123. Superoxide_dismutase_Ni-type.
[Graphical view]
PfamiPF09055. Sod_Ni. 1 hit.
[Graphical view]
SUPFAMiSSF109770. SSF109770. 1 hit.
TIGRFAMsiTIGR02753. sodN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSODN_STRSO
AccessioniPrimary (citable) accession number: P80734
Secondary accession number(s): Q9Z368
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.