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P80723

- BASP1_HUMAN

UniProt

P80723 - BASP1_HUMAN

Protein

Brain acid soluble protein 1

Gene

BASP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein domain specific binding Source: UniProtKB
    3. transcription corepressor activity Source: UniProtKB
    4. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. diaphragm development Source: UniProtKB
    2. glomerular visceral epithelial cell differentiation Source: UniProtKB
    3. gonad development Source: UniProtKB
    4. mesenchymal to epithelial transition Source: UniProtKB
    5. metanephric mesenchyme development Source: UniProtKB
    6. negative regulation of transcription, DNA-templated Source: UniProtKB
    7. positive regulation of heart growth Source: UniProtKB
    8. positive regulation of metanephric ureteric bud development Source: UniProtKB
    9. substantia nigra development Source: UniProt
    10. thorax and anterior abdomen determination Source: UniProtKB

    Protein family/group databases

    TCDBi1.A.71.1.1. the brain acid-soluble protein channel (basp1 channel) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brain acid soluble protein 1
    Alternative name(s):
    22 kDa neuronal tissue-enriched acidic protein
    Neuronal axonal membrane protein NAP-22
    Gene namesi
    Name:BASP1
    Synonyms:NAP22
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:957. BASP1.

    Subcellular locationi

    Cell membrane; Lipid-anchor. Cell projectiongrowth cone
    Note: Associated with the membranes of growth cones that form the tips of elongating axons.

    GO - Cellular componenti

    1. cell junction Source: HPA
    2. cytoplasm Source: UniProtKB
    3. cytoskeleton Source: ProtInc
    4. extracellular vesicular exosome Source: UniProt
    5. growth cone Source: UniProtKB-SubCell
    6. nuclear speck Source: UniProtKB
    7. nucleus Source: UniProtKB
    8. plasma membrane Source: HPA
    9. vesicle Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25261.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 227226Brain acid soluble protein 1PRO_0000142895Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycine1 Publication
    Modified residuei31 – 311Phosphothreonine1 Publication
    Modified residuei36 – 361Phosphothreonine3 Publications
    Modified residuei164 – 1641Phosphoserine1 Publication
    Modified residuei170 – 1701Phosphoserine1 Publication
    Modified residuei172 – 1721Phosphoserine1 Publication
    Modified residuei176 – 1761Phosphoserine1 Publication
    Modified residuei196 – 1961Phosphothreonine2 Publications
    Modified residuei205 – 2051Phosphoserine1 Publication

    Keywords - PTMi

    Lipoprotein, Myristate, Phosphoprotein

    Proteomic databases

    MaxQBiP80723.
    PaxDbiP80723.
    PeptideAtlasiP80723.
    PRIDEiP80723.

    PTM databases

    PhosphoSiteiP80723.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    BgeeiP80723.
    CleanExiHS_BASP1.
    GenevestigatoriP80723.

    Organism-specific databases

    HPAiHPA045218.
    HPA050333.

    Interactioni

    Protein-protein interaction databases

    BioGridi115680. 16 interactions.
    IntActiP80723. 7 interactions.
    MINTiMINT-5000418.
    STRINGi9606.ENSP00000319281.

    Structurei

    3D structure databases

    ProteinModelPortaliP80723.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BASP1 family.Curated

    Phylogenomic databases

    eggNOGiNOG46129.
    HOGENOMiHOG000095176.
    InParanoidiP80723.
    KOiK17272.
    OMAiQTIAVQD.
    OrthoDBiEOG7RJPVZ.

    Family and domain databases

    InterProiIPR008408. BASP1.
    [Graphical view]
    PANTHERiPTHR23212. PTHR23212. 1 hit.
    PfamiPF05466. BASP1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P80723-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGGKLSKKKK GYNVNDEKAK EKDKKAEGAA TEEEGTPKES EPQAAAEPAE    50
    AKEGKEKPDQ DAEGKAEEKE GEKDAAAAKE EAPKAEPEKT EGAAEAKAEP 100
    PKAPEQEQAA PGPAAGGEAP KAAEAAAAPA ESAAPAAGEE PSKEEGEPKK 150
    TEAPAAPAAQ ETKSDGAPAS DSKPGSSEAA PSSKETPAAT EAPSSTPKAQ 200
    GPAASAEEPK PVEAPAANSD QTVTVKE 227
    Length:227
    Mass (Da):22,693
    Last modified:January 23, 2007 - v2
    Checksum:i56FFFCEA441062AB
    GO
    Isoform 2 (identifier: P80723-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         88-141: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:173
    Mass (Da):17,664
    Checksum:i562F9FC9D05A565C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti45 – 451A → P in AAC67374. (PubMed:9749536)Curated
    Sequence conflicti114 – 1152AA → LR in AAC67374. (PubMed:9749536)Curated
    Sequence conflicti128 – 1325APAES → GPRPR in AAC67374. (PubMed:9749536)Curated
    Sequence conflicti152 – 1521E → G in AAH00518. (PubMed:15489334)Curated

    Mass spectrometryi

    Molecular mass is 22780 Da from positions 2 - 227. Determined by ESI. 1 Publication

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti76 – 761A → V.
    Corresponds to variant rs3733748 [ dbSNP | Ensembl ].
    VAR_048396

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei88 – 14154Missing in isoform 2. 1 PublicationVSP_037994Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039656 mRNA. Translation: AAC67374.1.
    BT019340 mRNA. Translation: AAV38147.1.
    BT019341 mRNA. Translation: AAV38148.1.
    AK295995 mRNA. Translation: BAG58770.1.
    CH471102 Genomic DNA. Translation: EAX08012.1.
    CH471102 Genomic DNA. Translation: EAX08013.1.
    BC000518 mRNA. Translation: AAH00518.1.
    CCDSiCCDS3888.1. [P80723-1]
    RefSeqiNP_001258535.1. NM_001271606.1. [P80723-1]
    NP_006308.3. NM_006317.4. [P80723-1]
    UniGeneiHs.201641.
    Hs.646924.

    Genome annotation databases

    EnsembliENST00000322611; ENSP00000319281; ENSG00000176788. [P80723-1]
    GeneIDi10409.
    KEGGihsa:10409.
    UCSCiuc003jfx.4. human. [P80723-1]

    Polymorphism databases

    DMDMi6686256.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039656 mRNA. Translation: AAC67374.1 .
    BT019340 mRNA. Translation: AAV38147.1 .
    BT019341 mRNA. Translation: AAV38148.1 .
    AK295995 mRNA. Translation: BAG58770.1 .
    CH471102 Genomic DNA. Translation: EAX08012.1 .
    CH471102 Genomic DNA. Translation: EAX08013.1 .
    BC000518 mRNA. Translation: AAH00518.1 .
    CCDSi CCDS3888.1. [P80723-1 ]
    RefSeqi NP_001258535.1. NM_001271606.1. [P80723-1 ]
    NP_006308.3. NM_006317.4. [P80723-1 ]
    UniGenei Hs.201641.
    Hs.646924.

    3D structure databases

    ProteinModelPortali P80723.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115680. 16 interactions.
    IntActi P80723. 7 interactions.
    MINTi MINT-5000418.
    STRINGi 9606.ENSP00000319281.

    Protein family/group databases

    TCDBi 1.A.71.1.1. the brain acid-soluble protein channel (basp1 channel) family.

    PTM databases

    PhosphoSitei P80723.

    Polymorphism databases

    DMDMi 6686256.

    Proteomic databases

    MaxQBi P80723.
    PaxDbi P80723.
    PeptideAtlasi P80723.
    PRIDEi P80723.

    Protocols and materials databases

    DNASUi 10409.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322611 ; ENSP00000319281 ; ENSG00000176788 . [P80723-1 ]
    GeneIDi 10409.
    KEGGi hsa:10409.
    UCSCi uc003jfx.4. human. [P80723-1 ]

    Organism-specific databases

    CTDi 10409.
    GeneCardsi GC05P017065.
    HGNCi HGNC:957. BASP1.
    HPAi HPA045218.
    HPA050333.
    MIMi 605940. gene.
    neXtProti NX_P80723.
    PharmGKBi PA25261.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46129.
    HOGENOMi HOG000095176.
    InParanoidi P80723.
    KOi K17272.
    OMAi QTIAVQD.
    OrthoDBi EOG7RJPVZ.

    Miscellaneous databases

    ChiTaRSi BASP1. human.
    GeneWikii BASP1.
    GenomeRNAii 10409.
    NextBioi 39453.
    PROi P80723.
    SOURCEi Search...

    Gene expression databases

    Bgeei P80723.
    CleanExi HS_BASP1.
    Genevestigatori P80723.

    Family and domain databases

    InterProi IPR008408. BASP1.
    [Graphical view ]
    PANTHERi PTHR23212. PTHR23212. 1 hit.
    Pfami PF05466. BASP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of bovine and human cDNAs encoding NAP-22 (22 kDa neuronal tissue-enriched acidic protein) homologs."
      Park S., Kim Y.-I., Kim B., Seong C., Oh Y., Baek K., Yoon J.
      Mol. Cells 8:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Subthalamic nucleus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    6. "The BASP1 family of myristoylated proteins abundant in axonal termini. Primary structure analysis and physico-chemical properties."
      Mosevitsky M.I., Capony J.-P., Skladchikova G.Y.U., Novitskaya V.A., Plekhanov A.Y.U., Zakharov V.V.
      Biochimie 79:373-384(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-227, MYRISTOYLATION AT GLY-2, MASS SPECTROMETRY.
      Tissue: Brain.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-36, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-31; THR-36; SER-164; SER-170; SER-172; SER-176; THR-196 AND SER-205, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-36 AND THR-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBASP1_HUMAN
    AccessioniPrimary (citable) accession number: P80723
    Secondary accession number(s): B4DJA8
    , D3DTD5, O43596, Q5U0S0, Q9BWA5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3