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Protein

Brain acid soluble protein 1

Gene

BASP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB
  • transcription corepressor activity Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176788-MONOMER.

Protein family/group databases

TCDBi1.A.71.1.1. the brain acid-soluble protein channel (basp1 channel) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Brain acid soluble protein 1
Alternative name(s):
22 kDa neuronal tissue-enriched acidic protein
Neuronal axonal membrane protein NAP-22
Gene namesi
Name:BASP1
Synonyms:NAP22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:957. BASP1.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: HPA
  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: ProtInc
  • extracellular exosome Source: UniProtKB
  • growth cone Source: UniProtKB-SubCell
  • nuclear speck Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: HPA
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10409.
OpenTargetsiENSG00000176788.
PharmGKBiPA25261.

Polymorphism and mutation databases

DMDMi6686256.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001428952 – 227Brain acid soluble protein 1Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine2 Publications1
Modified residuei31PhosphothreonineCombined sources1
Modified residuei36PhosphothreonineCombined sources1
Modified residuei40PhosphoserineBy similarity1
Cross-linki163Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei164PhosphoserineCombined sources1
Modified residuei170PhosphoserineCombined sources1
Modified residuei172PhosphoserineCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei195PhosphoserineBy similarity1
Modified residuei196PhosphothreonineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei219PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP80723.
MaxQBiP80723.
PaxDbiP80723.
PeptideAtlasiP80723.
PRIDEiP80723.
TopDownProteomicsiP80723-1. [P80723-1]
P80723-2. [P80723-2]

PTM databases

iPTMnetiP80723.
PhosphoSitePlusiP80723.
SwissPalmiP80723.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSG00000176788.
CleanExiHS_BASP1.
ExpressionAtlasiP80723. baseline and differential.
GenevisibleiP80723. HS.

Organism-specific databases

HPAiHPA045218.
HPA050333.

Interactioni

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115680. 56 interactors.
IntActiP80723. 34 interactors.
MINTiMINT-5000418.
STRINGi9606.ENSP00000319281.

Structurei

3D structure databases

ProteinModelPortaliP80723.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BASP1 family.Curated

Phylogenomic databases

eggNOGiENOG410J14G. Eukaryota.
ENOG4112CMG. LUCA.
GeneTreeiENSGT00730000111450.
HOGENOMiHOG000095176.
InParanoidiP80723.
KOiK17272.
OMAiHDENECP.
OrthoDBiEOG091G10E1.

Family and domain databases

InterProiIPR008408. BASP1.
[Graphical view]
PANTHERiPTHR23212. PTHR23212. 1 hit.
PfamiPF05466. BASP1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P80723-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGKLSKKKK GYNVNDEKAK EKDKKAEGAA TEEEGTPKES EPQAAAEPAE
60 70 80 90 100
AKEGKEKPDQ DAEGKAEEKE GEKDAAAAKE EAPKAEPEKT EGAAEAKAEP
110 120 130 140 150
PKAPEQEQAA PGPAAGGEAP KAAEAAAAPA ESAAPAAGEE PSKEEGEPKK
160 170 180 190 200
TEAPAAPAAQ ETKSDGAPAS DSKPGSSEAA PSSKETPAAT EAPSSTPKAQ
210 220
GPAASAEEPK PVEAPAANSD QTVTVKE
Length:227
Mass (Da):22,693
Last modified:January 23, 2007 - v2
Checksum:i56FFFCEA441062AB
GO
Isoform 2 (identifier: P80723-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-141: Missing.

Note: No experimental confirmation available.
Show »
Length:173
Mass (Da):17,664
Checksum:i562F9FC9D05A565C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45A → P in AAC67374 (PubMed:9749536).Curated1
Sequence conflicti114 – 115AA → LR in AAC67374 (PubMed:9749536).Curated2
Sequence conflicti128 – 132APAES → GPRPR in AAC67374 (PubMed:9749536).Curated5
Sequence conflicti152E → G in AAH00518 (PubMed:15489334).Curated1

Mass spectrometryi

Molecular mass is 22780 Da from positions 2 - 227. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04839676A → V.Corresponds to variant rs3733748dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03799488 – 141Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039656 mRNA. Translation: AAC67374.1.
BT019340 mRNA. Translation: AAV38147.1.
BT019341 mRNA. Translation: AAV38148.1.
AK295995 mRNA. Translation: BAG58770.1.
CH471102 Genomic DNA. Translation: EAX08012.1.
CH471102 Genomic DNA. Translation: EAX08013.1.
BC000518 mRNA. Translation: AAH00518.1.
CCDSiCCDS3888.1. [P80723-1]
RefSeqiNP_001258535.1. NM_001271606.1. [P80723-1]
NP_006308.3. NM_006317.4. [P80723-1]
UniGeneiHs.201641.
Hs.646924.

Genome annotation databases

EnsembliENST00000322611; ENSP00000319281; ENSG00000176788. [P80723-1]
ENST00000616743; ENSP00000482066; ENSG00000176788. [P80723-1]
GeneIDi10409.
KEGGihsa:10409.
UCSCiuc003jfx.5. human. [P80723-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039656 mRNA. Translation: AAC67374.1.
BT019340 mRNA. Translation: AAV38147.1.
BT019341 mRNA. Translation: AAV38148.1.
AK295995 mRNA. Translation: BAG58770.1.
CH471102 Genomic DNA. Translation: EAX08012.1.
CH471102 Genomic DNA. Translation: EAX08013.1.
BC000518 mRNA. Translation: AAH00518.1.
CCDSiCCDS3888.1. [P80723-1]
RefSeqiNP_001258535.1. NM_001271606.1. [P80723-1]
NP_006308.3. NM_006317.4. [P80723-1]
UniGeneiHs.201641.
Hs.646924.

3D structure databases

ProteinModelPortaliP80723.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115680. 56 interactors.
IntActiP80723. 34 interactors.
MINTiMINT-5000418.
STRINGi9606.ENSP00000319281.

Protein family/group databases

TCDBi1.A.71.1.1. the brain acid-soluble protein channel (basp1 channel) family.

PTM databases

iPTMnetiP80723.
PhosphoSitePlusiP80723.
SwissPalmiP80723.

Polymorphism and mutation databases

DMDMi6686256.

Proteomic databases

EPDiP80723.
MaxQBiP80723.
PaxDbiP80723.
PeptideAtlasiP80723.
PRIDEiP80723.
TopDownProteomicsiP80723-1. [P80723-1]
P80723-2. [P80723-2]

Protocols and materials databases

DNASUi10409.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322611; ENSP00000319281; ENSG00000176788. [P80723-1]
ENST00000616743; ENSP00000482066; ENSG00000176788. [P80723-1]
GeneIDi10409.
KEGGihsa:10409.
UCSCiuc003jfx.5. human. [P80723-1]

Organism-specific databases

CTDi10409.
DisGeNETi10409.
GeneCardsiBASP1.
HGNCiHGNC:957. BASP1.
HPAiHPA045218.
HPA050333.
MIMi605940. gene.
neXtProtiNX_P80723.
OpenTargetsiENSG00000176788.
PharmGKBiPA25261.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J14G. Eukaryota.
ENOG4112CMG. LUCA.
GeneTreeiENSGT00730000111450.
HOGENOMiHOG000095176.
InParanoidiP80723.
KOiK17272.
OMAiHDENECP.
OrthoDBiEOG091G10E1.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176788-MONOMER.

Miscellaneous databases

ChiTaRSiBASP1. human.
GeneWikiiBASP1.
GenomeRNAii10409.
PROiP80723.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176788.
CleanExiHS_BASP1.
ExpressionAtlasiP80723. baseline and differential.
GenevisibleiP80723. HS.

Family and domain databases

InterProiIPR008408. BASP1.
[Graphical view]
PANTHERiPTHR23212. PTHR23212. 1 hit.
PfamiPF05466. BASP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBASP1_HUMAN
AccessioniPrimary (citable) accession number: P80723
Secondary accession number(s): B4DJA8
, D3DTD5, O43596, Q5U0S0, Q9BWA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.