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P80695 (AMO_KLEOK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Primary amine oxidase

EC=1.4.3.21
Alternative name(s):
Monamine oxidase
Tyramine oxidase
Gene names
Name:maoA
Synonyms:tynA
Ordered Locus Names:KOX_19410
OrganismKlebsiella oxytoca (strain ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686) [Complete proteome] [HAMAP]
Taxonomic identifier1006551 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length752 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Active on tyramine, tryptamine, beta-phenethylamine and dopamine. Ref.2

Catalytic activity

RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2. Ref.2

Cofactor

Binds 1 copper ion per subunit. Ref.2

Contains 1 topaquinone per subunit By similarity. Ref.2

Subunit structure

Homodimer. Ref.2

Subcellular location

Periplasm Ref.2.

Post-translational modification

Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue By similarity.

Sequence similarities

Belongs to the copper/topaquinone oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Ref.2
Chain28 – 752725Primary amine oxidase
PRO_0000064108

Sequences

Sequence LengthMass (Da)Tools
P80695 [UniParc].

Last modified May 16, 2012. Version 2.
Checksum: 956A1D24B3963A9C

FASTA75283,624
        10         20         30         40         50         60 
MAILSPRKTA LALAVALSCA WQSPAFAHGG EAHMVPMDKT LQDFGADVQW DDYAQMFTLI 

        70         80         90        100        110        120 
KDGAYVKVKP GAKTAIVNGK TLELQVPVVM KDGKAWVSDT FINDVFQSGL DQTFQVEKRP 

       130        140        150        160        170        180 
HPLNSLSAAE ISAAVAIVKA AADFKPNTRF TEISLREPDK KAVWDFALNG TPVNAPRAAD 

       190        200        210        220        230        240 
VIMLDGKHVI EAVVDLQNKK VLSWTPIKDA HGMVLLDDFA SVQNIINASS EFAEVLKKHG 

       250        260        270        280        290        300 
IDDPSKVITT PLTVGYFDGK DGLKQDARLL KVVSYLDVGD GNYWAHPIEN LVAVVDLEQK 

       310        320        330        340        350        360 
KIIKIEEGPT IPVPMAARPY DGRDRVAPKI KPLDIIEPEG KNYTITGDMI HWQNWDFHLR 

       370        380        390        400        410        420 
MNSRVGPILS TVTYNDNGKK RQVMYEGSLG GMIVPYGDPD VGWYFKAYLD SGDYGMGTLT 

       430        440        450        460        470        480 
SPIVRGKDAP SNAVLLDETI ADYTGTPTTI PRAIAIFERY AGPEYKHQEM GKPNVSTERR 

       490        500        510        520        530        540 
ELVVRWISTV GNYDYIFDWV FHENGTIGID AGATGIEAVK GVQAKTMHDP SAKEDTRYGT 

       550        560        570        580        590        600 
LIDHNIVGTT HQHIYNFRLD LDVDGENNTL VAMDPEVKPN TAGGPRTSTM QINQYTIDSE 

       610        620        630        640        650        660 
QKAAQKFDPG TIRLLSNITK ENRMGNPVSY QIIPYAGGTH PVATGAKFAP DEWIYHRLSF 

       670        680        690        700        710        720 
MDKQLWVTRY HPTERFPEGK YPNRSIHDTG LGQYAKDDES LDNHDDVVWI TTGTTHVARA 

       730        740        750 
EEWPIMPTEW AHALLKPWNF FDETPTLGEK KE 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Klebsiella oxytoca strain KCTC 1686."
Shin S.H., Kim S., Kim J.Y., Yang K.-S., Seo J.-S.
Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686.
[2]"Distribution of amine oxidases and amine dehydrogenases in bacteria grown on primary amines and characterization of the amine oxidase from Klebsiella oxytoca."
Hacisalihoglu A., Jongejan J.A., Duine J.A.
Microbiology 143:505-512(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 28-47 AND 662-697, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, SUBUNIT, SUBCELLULAR LOCATION.
Strain: ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003218 Genomic DNA. Translation: AEX05604.1.
RefSeqYP_005019843.1. NC_016612.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEX05604; AEX05604; KOX_19410.
GeneID11661964.
KEGGkox:KOX_19410.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00276.

Enzyme and pathway databases

BRENDA1.4.3.6. 2811.

Family and domain databases

Gene3D2.70.98.20. 1 hit.
3.10.450.40. 2 hits.
3.30.457.10. 1 hit.
InterProIPR000269. Cu_amine_oxidase.
IPR012854. Cu_amine_oxidase-like_N.
IPR015798. Cu_amine_oxidase_C.
IPR016182. Cu_amine_oxidase_N-reg.
IPR015800. Cu_amine_oxidase_N2.
IPR015801. Cu_amine_oxidase_N2/3.
IPR015802. Cu_amine_oxidase_N3.
[Graphical view]
PANTHERPTHR10638. PTHR10638. 1 hit.
PfamPF01179. Cu_amine_oxid. 1 hit.
PF07833. Cu_amine_oxidN1. 1 hit.
PF02727. Cu_amine_oxidN2. 1 hit.
PF02728. Cu_amine_oxidN3. 1 hit.
[Graphical view]
SUPFAMSSF55383. Cu_amine_oxidase-like_N. 1 hit.
SSF54416. Cu_amine_oxidase_N-reg. 2 hits.
SSF49998. CuNH_oxidase. 1 hit.
PROSITEPS01164. COPPER_AMINE_OXID_1. 1 hit.
PS01165. COPPER_AMINE_OXID_2. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit. Uncertain.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMO_KLEOK
AccessionPrimary (citable) accession number: P80695
Secondary accession number(s): G8WBD9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 16, 2012
Last modified: April 3, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families