Reviewed, UniProtKB/Swiss-Prot P80682 (CUA2B_TENMO)

Names and origin

Protein names	Recommended name:     Larval cuticle protein A2B Alternative name(s):     TM-LCP A2B       Short name=TM-A2B
Organism	Tenebrio molitor (Yellow mealworm)
Taxonomic identifier	7067 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Coleoptera › Polyphaga › Cucujiformia › Tenebrionidae › Tenebrio

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the cuticle of the larva of Tenebrio molitor.
Domain	The tetrapeptide (A-A-P-[AV]) repeats found throughout the protein are also present in many proteins constituting the protective envelope of other species.
Sequence similarities	Contains 1 chitin-binding type R&R domain.
Mass spectrometry	Molecular mass is 12273.0 Da from positions 1 - 117. Determined by MALDI. Ref.1

Ontologies

Keywords
Cellular component	Cuticle
Domain	Repeat
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	structural constituent of cuticle Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 117	117	Larval cuticle protein A2B		PRO_0000196133
Regions
	Repeat	12 – 15	4	1
	Domain	29 – 95	67	Chitin-binding type R&R
	Repeat	108 – 111	4	2

Sequences

	Sequence		Length	Mass (Da)
	P80682-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 1982993C2D7B5D6C	FASTA	117	12,272
	10 20 30 40 50 60 GLIGSPVATY AAAPVAVAKT VVADEYDPHP QYQYGYDVQD GLTGDSKSQI ESRSGDVVQG 70 80 90 100 110 SYSLVDPDGT RRTVEYTADP INGFNAVVHR EPLVAKAVVA AHAPVVHAAP VAKIAHF

References

[1]	"Sequence studies of proteins from larval and pupal cuticle of the yellow meal worm, Tenebrio molitor." Andersen S.O., Rafn K., Roepstorff P. Insect Biochem. Mol. Biol. 27:121-131(1997) [PubMed: 9066122] [Abstract] Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY. Tissue: Cuticle.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR000618. Insect_cuticle. [Graphical view]
Pfam	PF00379. Chitin_bind_4. 1 hit. [Graphical view]
PRINTS	PR00947. CUTICLE.
PROSITE	PS00233. CHIT_BIND_RR_1. 1 hit. PS51155. CHIT_BIND_RR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CUA2B_TENMO

Accession

Primary (citable) accession number: P80682

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)