P80681 (CUA1A_TENMO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Larval cuticle protein A1A Alternative name(s): TM-LCP A1A Short name=TM-A1A
Organism	Tenebrio molitor (Yellow mealworm beetle)
Taxonomic identifier	7067 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Coleoptera › Polyphaga › Cucujiformia › Tenebrionidae › Tenebrio

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the cuticle of the larva of Tenebrio molitor.
Domain	The tetrapeptide (A-A-P-[AV]) repeats found throughout the protein are also present in many proteins constituting the protective envelope of other species.
Sequence similarities	Contains 1 chitin-binding type R&R domain.
Mass spectrometry	Molecular mass is 17692.5 Da from positions 1 - 174. Determined by ESI. Ref.1

Ontologies

Keywords
Cellular component	Cuticle
Domain	Repeat
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	structural constituent of cuticle Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 174	174	Larval cuticle protein A1A		PRO_0000196132
Regions
	Repeat	45 – 48	4	1
	Repeat	67 – 70	4	2
	Domain	84 – 150	67	Chitin-binding type R&R
	Repeat	155 – 158	4	3

Sequences

	Sequence		Length	Mass (Da)
	P80681 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 29BB3E508604AE1A	FASTA	174	17,692
	10 20 30 40 50 60 GLVGAPATLS TAPIAYGGYG GYGAYGGSLL RAAPIARVAS PLAYAAPVAR VAAPLAYAAP 70 80 90 100 110 120 YARAAVAAPV AVAKTVVADE YDPNPQYSFG YDVQDGLTGD SKNQVESRSG DVVQGSYSLV 130 140 150 160 170 DPDGTRRTVE YTADPINGFN AVVHREPLVA KAVVAAPAIA KVHAPLAYSG GYLH

References

[1]	"Sequence studies of proteins from larval and pupal cuticle of the yellow meal worm, Tenebrio molitor." Andersen S.O., Rafn K., Roepstorff P. Insect Biochem. Mol. Biol. 27:121-131(1997) [PubMed: 9066122] [Abstract] Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY. Tissue: Cuticle.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000618. Insect_cuticle. [Graphical view]
Pfam	PF00379. Chitin_bind_4. 1 hit. [Graphical view]
PRINTS	PR00947. CUTICLE.
PROSITE	PS00233. CHIT_BIND_RR_1. 1 hit. PS51155. CHIT_BIND_RR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CUA1A_TENMO

Accession

Primary (citable) accession number: P80681

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 30, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)