Reviewed, UniProtKB/Swiss-Prot P80671 (KAX84_LEIQH)

Names and origin

Protein names	Recommended name:     Potassium channel toxin alpha-KTx 8.4 Alternative name(s):     Leiuropeptide-3     Leiuropeptide III       Short name=LpIII
Organism	Leiurus quinquestriatus hebraeus (Yellow scorpion)
Taxonomic identifier	6884 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Leiurus

Protein attributes

Sequence length	29 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 8 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 29	29	Potassium channel toxin alpha-KTx 8.4		PRO_0000044543
Amino acid modifications
	Disulfide bond	3 ↔ 19		Ref.1
	Disulfide bond	6 ↔ 24		Ref.1
	Disulfide bond	10 ↔ 26		Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P80671-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: BF3F650C196C15B8	FASTA	29	3,214
	10 20 VSCEDCPDHC STQKARAKCD NDKCVCEPK

References

[1]

"Characterization of a new family of toxin-like peptides from the venom of the scorpion Leiurus quinquestriatus hebraeus. 1H-NMR structure of leiuropeptide II." Buisine E., Wieruszeski J.-M., Lippens G., Wouters D., Tartar A., Sautiere P. J. Pept. Res. 49:545-555(1997) [PubMed: 9266482] [Abstract] Cited for: PROTEIN SEQUENCE, STRUCTURE BY NMR, DISULFIDE BONDS. Tissue: Venom.

[2]

"Moving pieces in a taxonomic puzzle: venom 2D-LC/MS and data clustering analyses to infer phylogenetic relationships in some scorpions from the Buthidae family (Scorpiones)." Nascimento D.G., Rates B., Santos D.M., Verano-Braga T., Barbosa-Silva A., Dutra A.A.A., Biondi I., Martin-Eauclaire M.-F., De Lima M.E., Pimenta A.M.C. Toxicon 47:628-639(2006) [PubMed: 16551474] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR008911. Toxin_6. [Graphical view]
Pfam	PF05453. Toxin_6. 1 hit. [Graphical view]
PROSITE	PS01138. SCORP_SHORT_TOXIN. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAX84_LEIQH

Accession

Primary (citable) accession number: P80671

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 24, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Tox-Prot (Toxin Annotation Project)