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Protein

Gating modifier of anion channels 2

Gene
N/A
Organism
Leiurus quinquestriatus hebraeus (Yellow scorpion)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Specific and potent inhibitor of ClC-2/CLCN2 chloride channel. It slows ClC-2/CLCN2 activation by increasing the latency to first opening by nearly 8-fold but is unable to inhibit open channels, suggesting that this toxin inhibits channel activation gating.2 Publications

Miscellaneous

Does not inhibit ClC-0, ClC-1/CLCN1, ClC-3/CLCN3, ClC-4/CLCN4, CFTR chloride channel, GABRR, Cl(Ca), Shaker, and Kv1.2/KCNA2.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channel impairing toxin, Ion channel impairing toxin, Toxin, Voltage-gated chloride channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Gating modifier of anion channels 2
Alternative name(s):
Leiuropeptide II
Short name:
LpII
Leiuropeptide-21 Publication
Potassium channel toxin alpha-KTx 8.3
Toxin GaTx21 Publication
OrganismiLeiurus quinquestriatus hebraeus (Yellow scorpion)
Taxonomic identifieri6884 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeLeiurus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000445421 – 29Gating modifier of anion channels 2Add BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 191 Publication
Disulfide bondi6 ↔ 241 Publication
Disulfide bondi10 ↔ 261 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP80670.
SMRiP80670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR003614. Scorpion_toxin-like.
IPR008911. Toxin_alpha-KTx_8/9.
PfamiView protein in Pfam
PF05453. Toxin_6. 1 hit.
SUPFAMiSSF57095. SSF57095. 1 hit.

Sequencei

Sequence statusi: Complete.

P80670-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
VSCEDCPDHC STQKARAKCD NDKCVCEPI
Length:29
Mass (Da):3,199
Last modified:October 1, 1996 - v1
Checksum:iBC5F650C196C15B8
GO

Mass spectrometryi

Molecular mass is 3191.29 Da from positions 1 - 29. Determined by MALDI. 1 Publication

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKAX83_LEIQH
AccessioniPrimary (citable) accession number: P80670
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 10, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Caution

Has sequence similarities with potassium channel inhibitors, but inhibits chloride channels. It is why the systematic name 'Potassium channel toxin alpha-KTx 8.3' has been moved as alternative name.Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families