Peroxisomal membrane protein PAS20 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P80667 (PEX13_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 113. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Peroxisomal membrane protein PAS20

Alternative name(s):
Peroxin-13

Gene names

Name:	PEX13
Synonyms:	PAS20
Ordered Locus Names:	YLR191W
ORF Names:	L9470.1

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the peroxisomal translocation machinery with PEX14 and PEX17. Interacts with the PTS1 receptor (PAS10/PEX5).
Subcellular location	Peroxisome membrane; Single-pass membrane protein.
Miscellaneous	Present with 7900 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the peroxin-13 family. Contains 1 SH3 domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Membrane Peroxisome
Domain	SH3 domain Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	protein import into peroxisome matrix, docking Inferred from genetic interaction PubMed 10087260. Source: SGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW peroxisomal membrane Inferred from direct assay Ref.1 Ref.4. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
PEX10	Q05568	6	EBI-13206,EBI-13194
PEX14	P53112	10	EBI-13206,EBI-13212
PEX2	P32800	10	EBI-13206,EBI-13160

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 386

386

Peroxisomal membrane protein PAS20

PRO_0000058324

Regions

Topological domain

1 – 263

263

Lumenal Potential

Transmembrane

264 – 280

Helical; Potential

Topological domain

281 – 386

106

Cytoplasmic Potential

Domain

306 – 372

SH3

Secondary structure

386

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P80667 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: DBEA9A2372185860
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FASTA

386

42,706

        10         20         30         40         50         60 
MSSTAVPRPK PWETSASLEE PQRNAQSLSA MMTSNQQDSR PTEESNNSNS ASESAPEVLP 

        70         80         90        100        110        120 
RPAALNSSGT YGESNTIPGI YGNSNYGIPY DNNPYSMNSI YGNSIGRYGY GGSYYGNNYG 

       130        140        150        160        170        180 
SFYGGGYGAG AGYGMNNGSG LGESTKATFQ LIESLIGAVT GFAQMLESTY MATHNSFFTM 

       190        200        210        220        230        240 
ISVAEQFGNL KEMLGSFFGI FAIMKFLKKI LYRATKGRLG IPPKNFAESE GSKNKLIEDF 

       250        260        270        280        290        300 
QKFNDSGTIN SNEKATRRKI SWKPLLFFLM AVFGFPYLLN KFITKLQTSG TIRASQGNGS 

       310        320        330        340        350        360 
EPIDPSKLEF ARALYDFVPE NPEMEVALKK GDLMAILSKK DPLGRDSDWW KVRTKNGNIG 

       370        380 
YIPYNYIEII KRRKKIEHVD DETRTH

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins." Elgersma Y., Kwast L., Klein A., Voorn-Brouwer T., van den Berg M., Tabak H.F., Distel B. J. Cell Biol. 135:97-109(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. Hoheisel J.D. Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor." Erdmann R., Blobel G. J. Cell Biol. 135:111-121(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION. Strain: ATCC 204508 / S288c.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

S82971 Genomic DNA. Translation: AAB46885.1.
U37420 Genomic DNA. Translation: AAA79308.1.
U17246 Genomic DNA. Translation: AAB67453.1.
U14913 Genomic DNA. Translation: AAB67448.1.
BK006945 Genomic DNA. Translation: DAA09510.1.

PIR

S51436.

RefSeq

NP_013292.1. NM_001182078.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JQQ	X-ray	2.65	A/B/C/D	299-386	[»]
1N5Z	X-ray	2.70	A/B	299-386	[»]
1NM7	NMR	-	A	310-370	[»]
2V1R	X-ray	2.10	A/B	299-374	[»]

ProteinModelPortal

P80667.

SMR

P80667. Positions 299-376.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-2473N.

IntAct

P80667. 23 interactions.

MINT

MINT-433671.

STRING

4932.YLR191W.

Proteomic databases

PaxDb

P80667.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YLR191W; YLR191W; YLR191W.

GeneID

850888.

KEGG

sce:YLR191W.

Organism-specific databases

CYGD

YLR191w.

SGD

S000004181. PEX13.

Phylogenomic databases

eggNOG

NOG281515.

GeneTree

ENSGT00390000016883.

HOGENOM

HOG000158061.

K13344.

OMA

GFAQMLE.

OrthoDB

EOG4FXVHZ.

Gene expression databases

Genevestigator

P80667.

GermOnline

YLR191W. Saccharomyces cerevisiae.

Family and domain databases

InterPro

IPR007223. Peroxin-13_N.
IPR001452. SH3_domain.
[Graphical view]

Pfam

PF04088. Peroxin-13_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]

PRINTS

PR00452. SH3DOMAIN.

SMART

SM00326. SH3. 1 hit.
[Graphical view]

SUPFAM

SSF50044. SH3. 1 hit.

PROSITE

PS50002. SH3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P80667.

NextBio

967254.

Entry information

Entry name

PEX13_YEAST

Accession

Primary (citable) accession number: P80667
Secondary accession number(s): D6VYJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents