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Protein

Peroxisomal membrane protein PAS20

Gene

PEX13

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the peroxisomal translocation machinery with PEX14 and PEX17. Interacts with the PTS1 receptor (PAS10/PEX5).

Miscellaneous

Present with 7900 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein binding, bridging Source: SGD

GO - Biological processi

  • protein import into peroxisome matrix, docking Source: SGD

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32313-MONOMER
ReactomeiR-SCE-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-SCE-9033241 Peroxisomal protein import

Protein family/group databases

TCDBi3.A.20.1.5 the peroxisomal protein importer (ppi) family

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PAS20
Alternative name(s):
Peroxin-13
Gene namesi
Name:PEX13
Synonyms:PAS20
Ordered Locus Names:YLR191W
ORF Names:L9470.1
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR191W
SGDiS000004181 PEX13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 263LumenalSequence analysisAdd BLAST263
Transmembranei264 – 280HelicalSequence analysisAdd BLAST17
Topological domaini281 – 386CytoplasmicSequence analysisAdd BLAST106

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000583241 – 386Peroxisomal membrane protein PAS20Add BLAST386

Proteomic databases

MaxQBiP80667
PaxDbiP80667
PRIDEiP80667

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein binding, bridging Source: SGD

Protein-protein interaction databases

BioGridi31461, 268 interactors
ComplexPortaliCPX-1904 Peroxisomal docking Pex13/Pex14/Pex 15 complex
DIPiDIP-2473N
ELMiP80667
IntActiP80667, 80 interactors
MINTiP80667
STRINGi4932.YLR191W

Structurei

Secondary structure

1386
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi305 – 307Combined sources3
Beta strandi309 – 315Combined sources7
Turni322 – 324Combined sources3
Beta strandi333 – 340Combined sources8
Beta strandi346 – 353Combined sources8
Turni355 – 357Combined sources3
Beta strandi359 – 363Combined sources5
Helixi364 – 366Combined sources3
Beta strandi367 – 369Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JQQX-ray2.65A/B/C/D299-386[»]
1N5ZX-ray2.70A/B299-386[»]
1NM7NMR-A310-370[»]
2V1RX-ray2.10A/B299-374[»]
ProteinModelPortaliP80667
SMRiP80667
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80667

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini306 – 372SH3PROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the peroxin-13 family.Curated

Keywords - Domaini

SH3 domain, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000016883
HOGENOMiHOG000158061
InParanoidiP80667
KOiK13344
OMAiDSTFFAL
OrthoDBiEOG092C3U7P

Family and domain databases

InterProiView protein in InterPro
IPR007223 Peroxin-13_N
IPR035463 Pex13
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR19332 PTHR19332, 1 hit
PfamiView protein in Pfam
PF04088 Peroxin-13_N, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

P80667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTAVPRPK PWETSASLEE PQRNAQSLSA MMTSNQQDSR PTEESNNSNS
60 70 80 90 100
ASESAPEVLP RPAALNSSGT YGESNTIPGI YGNSNYGIPY DNNPYSMNSI
110 120 130 140 150
YGNSIGRYGY GGSYYGNNYG SFYGGGYGAG AGYGMNNGSG LGESTKATFQ
160 170 180 190 200
LIESLIGAVT GFAQMLESTY MATHNSFFTM ISVAEQFGNL KEMLGSFFGI
210 220 230 240 250
FAIMKFLKKI LYRATKGRLG IPPKNFAESE GSKNKLIEDF QKFNDSGTIN
260 270 280 290 300
SNEKATRRKI SWKPLLFFLM AVFGFPYLLN KFITKLQTSG TIRASQGNGS
310 320 330 340 350
EPIDPSKLEF ARALYDFVPE NPEMEVALKK GDLMAILSKK DPLGRDSDWW
360 370 380
KVRTKNGNIG YIPYNYIEII KRRKKIEHVD DETRTH
Length:386
Mass (Da):42,706
Last modified:October 1, 1996 - v1
Checksum:iDBEA9A2372185860
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82971 Genomic DNA Translation: AAB46885.1
U37420 Genomic DNA Translation: AAA79308.1
U17246 Genomic DNA Translation: AAB67453.1
U14913 Genomic DNA Translation: AAB67448.1
BK006945 Genomic DNA Translation: DAA09510.1
PIRiS51436
RefSeqiNP_013292.1, NM_001182078.1

Genome annotation databases

EnsemblFungiiYLR191W; YLR191W; YLR191W
GeneIDi850888
KEGGisce:YLR191W

Similar proteinsi

Entry informationi

Entry nameiPEX13_YEAST
AccessioniPrimary (citable) accession number: P80667
Secondary accession number(s): D6VYJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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