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P80667

- PEX13_YEAST

UniProt

P80667 - PEX13_YEAST

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Protein

Peroxisomal membrane protein PAS20

Gene
PEX13, PAS20, YLR191W, L9470.1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the peroxisomal translocation machinery with PEX14 and PEX17. Interacts with the PTS1 receptor (PAS10/PEX5).

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein binding, bridging Source: SGD

GO - Biological processi

  1. protein import into peroxisome matrix, docking Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32313-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PAS20
Alternative name(s):
Peroxin-13
Gene namesi
Name:PEX13
Synonyms:PAS20
Ordered Locus Names:YLR191W
ORF Names:L9470.1
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR191w.
SGDiS000004181. PEX13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 263263Lumenal Reviewed predictionAdd
BLAST
Transmembranei264 – 28017Helical; Reviewed predictionAdd
BLAST
Topological domaini281 – 386106Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. peroxisomal membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386Peroxisomal membrane protein PAS20PRO_0000058324Add
BLAST

Proteomic databases

MaxQBiP80667.
PaxDbiP80667.

Expressioni

Gene expression databases

GenevestigatoriP80667.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APP1P539332EBI-13206,EBI-28798
INN1P539012EBI-13206,EBI-28955
LAS17Q124462EBI-13206,EBI-10022
PEX10Q055687EBI-13206,EBI-13194
PEX12Q043706EBI-13206,EBI-2077297
PEX14P5311217EBI-13206,EBI-13212
PEX2P3280010EBI-13206,EBI-13160
PEX5P350566EBI-13206,EBI-13170
PRK1P404942EBI-13206,EBI-9703
STE20Q034973EBI-13206,EBI-18285
STP22P256042EBI-13206,EBI-411625
UBP7P404532EBI-13206,EBI-19857

Protein-protein interaction databases

BioGridi31461. 123 interactions.
DIPiDIP-2473N.
IntActiP80667. 79 interactions.
MINTiMINT-433671.
STRINGi4932.YLR191W.

Structurei

Secondary structure

1
386
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi305 – 3073
Beta strandi309 – 3157
Turni322 – 3243
Beta strandi333 – 3408
Beta strandi346 – 3538
Turni355 – 3573
Beta strandi359 – 3635
Helixi364 – 3663
Beta strandi367 – 3693

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JQQX-ray2.65A/B/C/D299-386[»]
1N5ZX-ray2.70A/B299-386[»]
1NM7NMR-A310-370[»]
2V1RX-ray2.10A/B299-374[»]
ProteinModelPortaliP80667.
SMRiP80667. Positions 299-376.

Miscellaneous databases

EvolutionaryTraceiP80667.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini306 – 37267SH3Add
BLAST

Sequence similaritiesi

Belongs to the peroxin-13 family.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281515.
GeneTreeiENSGT00390000016883.
HOGENOMiHOG000158061.
KOiK13344.
OMAiNRTASNY.
OrthoDBiEOG7XDBSF.

Family and domain databases

InterProiIPR007223. Peroxin-13_N.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF04088. Peroxin-13_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80667-1 [UniParc]FASTAAdd to Basket

« Hide

MSSTAVPRPK PWETSASLEE PQRNAQSLSA MMTSNQQDSR PTEESNNSNS    50
ASESAPEVLP RPAALNSSGT YGESNTIPGI YGNSNYGIPY DNNPYSMNSI 100
YGNSIGRYGY GGSYYGNNYG SFYGGGYGAG AGYGMNNGSG LGESTKATFQ 150
LIESLIGAVT GFAQMLESTY MATHNSFFTM ISVAEQFGNL KEMLGSFFGI 200
FAIMKFLKKI LYRATKGRLG IPPKNFAESE GSKNKLIEDF QKFNDSGTIN 250
SNEKATRRKI SWKPLLFFLM AVFGFPYLLN KFITKLQTSG TIRASQGNGS 300
EPIDPSKLEF ARALYDFVPE NPEMEVALKK GDLMAILSKK DPLGRDSDWW 350
KVRTKNGNIG YIPYNYIEII KRRKKIEHVD DETRTH 386
Length:386
Mass (Da):42,706
Last modified:October 1, 1996 - v1
Checksum:iDBEA9A2372185860
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S82971 Genomic DNA. Translation: AAB46885.1.
U37420 Genomic DNA. Translation: AAA79308.1.
U17246 Genomic DNA. Translation: AAB67453.1.
U14913 Genomic DNA. Translation: AAB67448.1.
BK006945 Genomic DNA. Translation: DAA09510.1.
PIRiS51436.
RefSeqiNP_013292.1. NM_001182078.1.

Genome annotation databases

EnsemblFungiiYLR191W; YLR191W; YLR191W.
GeneIDi850888.
KEGGisce:YLR191W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S82971 Genomic DNA. Translation: AAB46885.1 .
U37420 Genomic DNA. Translation: AAA79308.1 .
U17246 Genomic DNA. Translation: AAB67453.1 .
U14913 Genomic DNA. Translation: AAB67448.1 .
BK006945 Genomic DNA. Translation: DAA09510.1 .
PIRi S51436.
RefSeqi NP_013292.1. NM_001182078.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JQQ X-ray 2.65 A/B/C/D 299-386 [» ]
1N5Z X-ray 2.70 A/B 299-386 [» ]
1NM7 NMR - A 310-370 [» ]
2V1R X-ray 2.10 A/B 299-374 [» ]
ProteinModelPortali P80667.
SMRi P80667. Positions 299-376.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31461. 123 interactions.
DIPi DIP-2473N.
IntActi P80667. 79 interactions.
MINTi MINT-433671.
STRINGi 4932.YLR191W.

Protein family/group databases

TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBi P80667.
PaxDbi P80667.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR191W ; YLR191W ; YLR191W .
GeneIDi 850888.
KEGGi sce:YLR191W.

Organism-specific databases

CYGDi YLR191w.
SGDi S000004181. PEX13.

Phylogenomic databases

eggNOGi NOG281515.
GeneTreei ENSGT00390000016883.
HOGENOMi HOG000158061.
KOi K13344.
OMAi NRTASNY.
OrthoDBi EOG7XDBSF.

Enzyme and pathway databases

BioCyci YEAST:G3O-32313-MONOMER.

Miscellaneous databases

EvolutionaryTracei P80667.
NextBioi 967254.
PROi P80667.

Gene expression databases

Genevestigatori P80667.

Family and domain databases

InterProi IPR007223. Peroxin-13_N.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF04088. Peroxin-13_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins."
    Elgersma Y., Kwast L., Klein A., Voorn-Brouwer T., van den Berg M., Tabak H.F., Distel B.
    J. Cell Biol. 135:97-109(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor."
    Erdmann R., Blobel G.
    J. Cell Biol. 135:111-121(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPEX13_YEAST
AccessioniPrimary (citable) accession number: P80667
Secondary accession number(s): D6VYJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7900 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3

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