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P80667

- PEX13_YEAST

UniProt

P80667 - PEX13_YEAST

Protein

Peroxisomal membrane protein PAS20

Gene

PEX13

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Component of the peroxisomal translocation machinery with PEX14 and PEX17. Interacts with the PTS1 receptor (PAS10/PEX5).

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein binding, bridging Source: SGD

    GO - Biological processi

    1. protein import into peroxisome matrix, docking Source: SGD

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32313-MONOMER.

    Protein family/group databases

    TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal membrane protein PAS20
    Alternative name(s):
    Peroxin-13
    Gene namesi
    Name:PEX13
    Synonyms:PAS20
    Ordered Locus Names:YLR191W
    ORF Names:L9470.1
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    CYGDiYLR191w.
    SGDiS000004181. PEX13.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. peroxisomal membrane Source: SGD

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 386386Peroxisomal membrane protein PAS20PRO_0000058324Add
    BLAST

    Proteomic databases

    MaxQBiP80667.
    PaxDbiP80667.

    Expressioni

    Gene expression databases

    GenevestigatoriP80667.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    APP1P539332EBI-13206,EBI-28798
    INN1P539012EBI-13206,EBI-28955
    LAS17Q124462EBI-13206,EBI-10022
    PEX10Q055687EBI-13206,EBI-13194
    PEX12Q043706EBI-13206,EBI-2077297
    PEX14P5311217EBI-13206,EBI-13212
    PEX2P3280010EBI-13206,EBI-13160
    PEX5P350566EBI-13206,EBI-13170
    PRK1P404942EBI-13206,EBI-9703
    STE20Q034973EBI-13206,EBI-18285
    STP22P256042EBI-13206,EBI-411625
    UBP7P404532EBI-13206,EBI-19857

    Protein-protein interaction databases

    BioGridi31461. 123 interactions.
    DIPiDIP-2473N.
    IntActiP80667. 79 interactions.
    MINTiMINT-433671.
    STRINGi4932.YLR191W.

    Structurei

    Secondary structure

    1
    386
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi305 – 3073
    Beta strandi309 – 3157
    Turni322 – 3243
    Beta strandi333 – 3408
    Beta strandi346 – 3538
    Turni355 – 3573
    Beta strandi359 – 3635
    Helixi364 – 3663
    Beta strandi367 – 3693

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JQQX-ray2.65A/B/C/D299-386[»]
    1N5ZX-ray2.70A/B299-386[»]
    1NM7NMR-A310-370[»]
    2V1RX-ray2.10A/B299-374[»]
    ProteinModelPortaliP80667.
    SMRiP80667. Positions 299-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP80667.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 263263LumenalSequence AnalysisAdd
    BLAST
    Topological domaini281 – 386106CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei264 – 28017HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini306 – 37267SH3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peroxin-13 family.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG281515.
    GeneTreeiENSGT00390000016883.
    HOGENOMiHOG000158061.
    KOiK13344.
    OMAiNRTASNY.
    OrthoDBiEOG7XDBSF.

    Family and domain databases

    InterProiIPR007223. Peroxin-13_N.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF04088. Peroxin-13_N. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P80667-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSTAVPRPK PWETSASLEE PQRNAQSLSA MMTSNQQDSR PTEESNNSNS    50
    ASESAPEVLP RPAALNSSGT YGESNTIPGI YGNSNYGIPY DNNPYSMNSI 100
    YGNSIGRYGY GGSYYGNNYG SFYGGGYGAG AGYGMNNGSG LGESTKATFQ 150
    LIESLIGAVT GFAQMLESTY MATHNSFFTM ISVAEQFGNL KEMLGSFFGI 200
    FAIMKFLKKI LYRATKGRLG IPPKNFAESE GSKNKLIEDF QKFNDSGTIN 250
    SNEKATRRKI SWKPLLFFLM AVFGFPYLLN KFITKLQTSG TIRASQGNGS 300
    EPIDPSKLEF ARALYDFVPE NPEMEVALKK GDLMAILSKK DPLGRDSDWW 350
    KVRTKNGNIG YIPYNYIEII KRRKKIEHVD DETRTH 386
    Length:386
    Mass (Da):42,706
    Last modified:October 1, 1996 - v1
    Checksum:iDBEA9A2372185860
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S82971 Genomic DNA. Translation: AAB46885.1.
    U37420 Genomic DNA. Translation: AAA79308.1.
    U17246 Genomic DNA. Translation: AAB67453.1.
    U14913 Genomic DNA. Translation: AAB67448.1.
    BK006945 Genomic DNA. Translation: DAA09510.1.
    PIRiS51436.
    RefSeqiNP_013292.1. NM_001182078.1.

    Genome annotation databases

    EnsemblFungiiYLR191W; YLR191W; YLR191W.
    GeneIDi850888.
    KEGGisce:YLR191W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S82971 Genomic DNA. Translation: AAB46885.1 .
    U37420 Genomic DNA. Translation: AAA79308.1 .
    U17246 Genomic DNA. Translation: AAB67453.1 .
    U14913 Genomic DNA. Translation: AAB67448.1 .
    BK006945 Genomic DNA. Translation: DAA09510.1 .
    PIRi S51436.
    RefSeqi NP_013292.1. NM_001182078.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JQQ X-ray 2.65 A/B/C/D 299-386 [» ]
    1N5Z X-ray 2.70 A/B 299-386 [» ]
    1NM7 NMR - A 310-370 [» ]
    2V1R X-ray 2.10 A/B 299-374 [» ]
    ProteinModelPortali P80667.
    SMRi P80667. Positions 299-376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31461. 123 interactions.
    DIPi DIP-2473N.
    IntActi P80667. 79 interactions.
    MINTi MINT-433671.
    STRINGi 4932.YLR191W.

    Protein family/group databases

    TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Proteomic databases

    MaxQBi P80667.
    PaxDbi P80667.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR191W ; YLR191W ; YLR191W .
    GeneIDi 850888.
    KEGGi sce:YLR191W.

    Organism-specific databases

    CYGDi YLR191w.
    SGDi S000004181. PEX13.

    Phylogenomic databases

    eggNOGi NOG281515.
    GeneTreei ENSGT00390000016883.
    HOGENOMi HOG000158061.
    KOi K13344.
    OMAi NRTASNY.
    OrthoDBi EOG7XDBSF.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32313-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P80667.
    NextBioi 967254.
    PROi P80667.

    Gene expression databases

    Genevestigatori P80667.

    Family and domain databases

    InterProi IPR007223. Peroxin-13_N.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF04088. Peroxin-13_N. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins."
      Elgersma Y., Kwast L., Klein A., Voorn-Brouwer T., van den Berg M., Tabak H.F., Distel B.
      J. Cell Biol. 135:97-109(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor."
      Erdmann R., Blobel G.
      J. Cell Biol. 135:111-121(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPEX13_YEAST
    AccessioniPrimary (citable) accession number: P80667
    Secondary accession number(s): D6VYJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 7900 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3