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P80667 (PEX13_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal membrane protein PAS20
Alternative name(s):
Peroxin-13
Gene names
Name:PEX13
Synonyms:PAS20
Ordered Locus Names:YLR191W
ORF Names:L9470.1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the peroxisomal translocation machinery with PEX14 and PEX17. Interacts with the PTS1 receptor (PAS10/PEX5).

Subcellular location

Peroxisome membrane; Single-pass membrane protein.

Miscellaneous

Present with 7900 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the peroxin-13 family.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 386386Peroxisomal membrane protein PAS20
PRO_0000058324

Regions

Topological domain1 – 263263Lumenal Potential
Transmembrane264 – 28017Helical; Potential
Topological domain281 – 386106Cytoplasmic Potential
Domain306 – 37267SH3

Secondary structure

................. 386
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P80667 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: DBEA9A2372185860

FASTA38642,706
        10         20         30         40         50         60 
MSSTAVPRPK PWETSASLEE PQRNAQSLSA MMTSNQQDSR PTEESNNSNS ASESAPEVLP 

        70         80         90        100        110        120 
RPAALNSSGT YGESNTIPGI YGNSNYGIPY DNNPYSMNSI YGNSIGRYGY GGSYYGNNYG 

       130        140        150        160        170        180 
SFYGGGYGAG AGYGMNNGSG LGESTKATFQ LIESLIGAVT GFAQMLESTY MATHNSFFTM 

       190        200        210        220        230        240 
ISVAEQFGNL KEMLGSFFGI FAIMKFLKKI LYRATKGRLG IPPKNFAESE GSKNKLIEDF 

       250        260        270        280        290        300 
QKFNDSGTIN SNEKATRRKI SWKPLLFFLM AVFGFPYLLN KFITKLQTSG TIRASQGNGS 

       310        320        330        340        350        360 
EPIDPSKLEF ARALYDFVPE NPEMEVALKK GDLMAILSKK DPLGRDSDWW KVRTKNGNIG 

       370        380 
YIPYNYIEII KRRKKIEHVD DETRTH 

« Hide

References

« Hide 'large scale' references
[1]"The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins."
Elgersma Y., Kwast L., Klein A., Voorn-Brouwer T., van den Berg M., Tabak H.F., Distel B.
J. Cell Biol. 135:97-109(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor."
Erdmann R., Blobel G.
J. Cell Biol. 135:111-121(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
Strain: ATCC 204508 / S288c.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S82971 Genomic DNA. Translation: AAB46885.1.
U37420 Genomic DNA. Translation: AAA79308.1.
U17246 Genomic DNA. Translation: AAB67453.1.
U14913 Genomic DNA. Translation: AAB67448.1.
BK006945 Genomic DNA. Translation: DAA09510.1.
PIRS51436.
RefSeqNP_013292.1. NM_001182078.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JQQX-ray2.65A/B/C/D299-386[»]
1N5ZX-ray2.70A/B299-386[»]
1NM7NMR-A310-370[»]
2V1RX-ray2.10A/B299-374[»]
ProteinModelPortalP80667.
SMRP80667. Positions 299-376.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31461. 123 interactions.
DIPDIP-2473N.
IntActP80667. 79 interactions.
MINTMINT-433671.
STRING4932.YLR191W.

Protein family/group databases

TCDB3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

PaxDbP80667.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR191W; YLR191W; YLR191W.
GeneID850888.
KEGGsce:YLR191W.

Organism-specific databases

CYGDYLR191w.
SGDS000004181. PEX13.

Phylogenomic databases

eggNOGNOG281515.
GeneTreeENSGT00390000016883.
HOGENOMHOG000158061.
KOK13344.
OMANRTASNY.
OrthoDBEOG7XDBSF.

Enzyme and pathway databases

BioCycYEAST:G3O-32313-MONOMER.

Gene expression databases

GenevestigatorP80667.

Family and domain databases

InterProIPR007223. Peroxin-13_N.
IPR001452. SH3_domain.
[Graphical view]
PfamPF04088. Peroxin-13_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP80667.
NextBio967254.
PROP80667.

Entry information

Entry namePEX13_YEAST
AccessionPrimary (citable) accession number: P80667
Secondary accession number(s): D6VYJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references