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P80646 (CTRB_GADMO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Biological processDigestion
   Cellular componentSecreted
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Zymogen
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdigestion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1313Chymotrypsin B chain A
PRO_0000027647
Propeptide14 – 152
PRO_0000027648
Chain16 – 245230Chymotrypsin B chain B
PRO_0000027649

Regions

Domain16 – 243228Peptidase S1

Sites

Active site571Charge relay system By similarity
Active site1011Charge relay system By similarity
Active site1951Charge relay system By similarity

Amino acid modifications

Disulfide bond1 ↔ 121 By similarity
Disulfide bond42 ↔ 58 By similarity
Disulfide bond135 ↔ 201 By similarity
Disulfide bond167 ↔ 182 By similarity
Disulfide bond191 ↔ 220 By similarity

Experimental info

Sequence conflict9 – 113QVT → VIS AA sequence Ref.2
Sequence conflict261S → T AA sequence Ref.2
Sequence conflict28 – 292PW → Y AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P80646 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 74FE0D425517AB02

FASTA24526,260
        10         20         30         40         50         60 
CGSPAIQPQV TGYARIVNGE EAVPHSWPWQ VSLQQSNGFH FCGGSLINEN WVVTAAHCNV 

        70         80         90        100        110        120 
RTYHRVIVGE HDKASDENIQ ILKPSMVFTH PKWDSRTINN DISLIKLASP AVLGTNVSPV 

       130        140        150        160        170        180 
CLGESSDVFA PGMKCVTSGW GLTRYNAPGT PNKLQQAALP LMSNEECSQT WGNNMISDVM 

       190        200        210        220        230        240 
ICAGAAGATS CMGDSGGPLV CQKDNVWTLV GIVSWGSSRC SVTTPAVYAR VTELRGWVDQ 


ILAAN 

« Hide

References

[1]"Structure of chymotrypsin variant B from Atlantic cod, Gadus morhua."
Leth-Larsen R., Asgeirsson B., Thorolfsson M., Noerregaard-Madsen M., Hoejrup P.
Biochim. Biophys. Acta 1297:49-56(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Pyloric caecum.
[2]"Structural and kinetic properties of chymotrypsin from Atlantic cod (Gadus morhua). Comparison with bovine chymotrypsin."
Asgeirsson B., Bjarnason J.B.
Comp. Biochem. Physiol. 99B:327-335(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-12 AND 16-31.
Tissue: Pyloric caecum.

Cross-references

3D structure databases

ProteinModelPortalP80646.
SMRP80646. Positions 1-245.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.437.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGMOT00000010525; ENSGMOP00000010246; ENSGMOG00000009511.
ENSGMOT00000010541; ENSGMOP00000010261; ENSGMOG00000009511.

Phylogenomic databases

GeneTreeENSGT00730000110306.
HOVERGENHBG013304.
OrthoDBEOG7MKW6Q.
TreeFamTF330455.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCTRB_GADMO
AccessionPrimary (citable) accession number: P80646
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries