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P80646

- CTRB_GADMO

UniProt

P80646 - CTRB_GADMO

Protein

Chymotrypsin B

Gene
N/A
Organism
Gadus morhua (Atlantic cod)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei57 – 571Charge relay systemBy similarity
    Active sitei101 – 1011Charge relay systemBy similarity
    Active sitei195 – 1951Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. digestion Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Digestion

    Protein family/group databases

    MEROPSiS01.437.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chymotrypsin B (EC:3.4.21.1)
    Cleaved into the following 2 chains:
    OrganismiGadus morhua (Atlantic cod)
    Taxonomic identifieri8049 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1313Chymotrypsin B chain APRO_0000027647Add
    BLAST
    Propeptidei14 – 1521 PublicationPRO_0000027648
    Chaini16 – 245230Chymotrypsin B chain BPRO_0000027649Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi1 ↔ 121PROSITE-ProRule annotation
    Disulfide bondi42 ↔ 58PROSITE-ProRule annotation
    Disulfide bondi135 ↔ 201PROSITE-ProRule annotation
    Disulfide bondi167 ↔ 182PROSITE-ProRule annotation
    Disulfide bondi191 ↔ 220PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliP80646.
    SMRiP80646. Positions 1-245.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 243228Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110306.
    HOVERGENiHBG013304.
    OrthoDBiEOG7MKW6Q.
    TreeFamiTF330455.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80646-1 [UniParc]FASTAAdd to Basket

    « Hide

    CGSPAIQPQV TGYARIVNGE EAVPHSWPWQ VSLQQSNGFH FCGGSLINEN    50
    WVVTAAHCNV RTYHRVIVGE HDKASDENIQ ILKPSMVFTH PKWDSRTINN 100
    DISLIKLASP AVLGTNVSPV CLGESSDVFA PGMKCVTSGW GLTRYNAPGT 150
    PNKLQQAALP LMSNEECSQT WGNNMISDVM ICAGAAGATS CMGDSGGPLV 200
    CQKDNVWTLV GIVSWGSSRC SVTTPAVYAR VTELRGWVDQ ILAAN 245
    Length:245
    Mass (Da):26,260
    Last modified:October 1, 1996 - v1
    Checksum:i74FE0D425517AB02
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 113QVT → VIS AA sequence (PubMed:1764912)Curated
    Sequence conflicti26 – 261S → T AA sequence (PubMed:1764912)Curated
    Sequence conflicti28 – 292PW → Y AA sequence (PubMed:1764912)Curated

    Genome annotation databases

    EnsembliENSGMOT00000010525; ENSGMOP00000010246; ENSGMOG00000009511.
    ENSGMOT00000010541; ENSGMOP00000010261; ENSGMOG00000009511.

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P80646.
    SMRi P80646. Positions 1-245.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.437.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGMOT00000010525 ; ENSGMOP00000010246 ; ENSGMOG00000009511 .
    ENSGMOT00000010541 ; ENSGMOP00000010261 ; ENSGMOG00000009511 .

    Phylogenomic databases

    GeneTreei ENSGT00730000110306.
    HOVERGENi HBG013304.
    OrthoDBi EOG7MKW6Q.
    TreeFami TF330455.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: PROTEIN SEQUENCE.
      Tissue: Pyloric caecum.
    2. "Structural and kinetic properties of chymotrypsin from Atlantic cod (Gadus morhua). Comparison with bovine chymotrypsin."
      Asgeirsson B., Bjarnason J.B.
      Comp. Biochem. Physiol. 99B:327-335(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-12 AND 16-31.
      Tissue: Pyloric caecum.

    Entry informationi

    Entry nameiCTRB_GADMO
    AccessioniPrimary (citable) accession number: P80646
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3