Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P80646

- CTRB_GADMO

UniProt

P80646 - CTRB_GADMO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Chymotrypsin B

Gene
N/A
Organism
Gadus morhua (Atlantic cod)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei57 – 571Charge relay systemBy similarity
Active sitei101 – 1011Charge relay systemBy similarity
Active sitei195 – 1951Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Protein family/group databases

MEROPSiS01.437.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin B (EC:3.4.21.1)
Cleaved into the following 2 chains:
OrganismiGadus morhua (Atlantic cod)
Taxonomic identifieri8049 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1313Chymotrypsin B chain APRO_0000027647Add
BLAST
Propeptidei14 – 1521 PublicationPRO_0000027648
Chaini16 – 245230Chymotrypsin B chain BPRO_0000027649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi1 ↔ 121PROSITE-ProRule annotation
Disulfide bondi42 ↔ 58PROSITE-ProRule annotation
Disulfide bondi135 ↔ 201PROSITE-ProRule annotation
Disulfide bondi167 ↔ 182PROSITE-ProRule annotation
Disulfide bondi191 ↔ 220PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP80646.
SMRiP80646. Positions 1-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 243228Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG013304.
OrthoDBiEOG7MKW6Q.
TreeFamiTF330455.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80646 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
CGSPAIQPQV TGYARIVNGE EAVPHSWPWQ VSLQQSNGFH FCGGSLINEN
60 70 80 90 100
WVVTAAHCNV RTYHRVIVGE HDKASDENIQ ILKPSMVFTH PKWDSRTINN
110 120 130 140 150
DISLIKLASP AVLGTNVSPV CLGESSDVFA PGMKCVTSGW GLTRYNAPGT
160 170 180 190 200
PNKLQQAALP LMSNEECSQT WGNNMISDVM ICAGAAGATS CMGDSGGPLV
210 220 230 240
CQKDNVWTLV GIVSWGSSRC SVTTPAVYAR VTELRGWVDQ ILAAN
Length:245
Mass (Da):26,260
Last modified:October 1, 1996 - v1
Checksum:i74FE0D425517AB02
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 113QVT → VIS AA sequence (PubMed:1764912)Curated
Sequence conflicti26 – 261S → T AA sequence (PubMed:1764912)Curated
Sequence conflicti28 – 292PW → Y AA sequence (PubMed:1764912)Curated

Genome annotation databases

EnsembliENSGMOT00000010525; ENSGMOP00000010246; ENSGMOG00000009511.
ENSGMOT00000010541; ENSGMOP00000010261; ENSGMOG00000009511.

Cross-referencesi

3D structure databases

ProteinModelPortali P80646.
SMRi P80646. Positions 1-245.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.437.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGMOT00000010525 ; ENSGMOP00000010246 ; ENSGMOG00000009511 .
ENSGMOT00000010541 ; ENSGMOP00000010261 ; ENSGMOG00000009511 .

Phylogenomic databases

HOVERGENi HBG013304.
OrthoDBi EOG7MKW6Q.
TreeFami TF330455.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: PROTEIN SEQUENCE.
    Tissue: Pyloric caecum.
  2. "Structural and kinetic properties of chymotrypsin from Atlantic cod (Gadus morhua). Comparison with bovine chymotrypsin."
    Asgeirsson B., Bjarnason J.B.
    Comp. Biochem. Physiol. 99B:327-335(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-12 AND 16-31.
    Tissue: Pyloric caecum.

Entry informationi

Entry nameiCTRB_GADMO
AccessioniPrimary (citable) accession number: P80646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3