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P80646

- CTRB_GADMO

UniProt

P80646 - CTRB_GADMO

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Protein
Chymotrypsin B
Gene
N/A
Organism
Gadus morhua (Atlantic cod)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei57 – 571Charge relay system By similarity
Active sitei101 – 1011Charge relay system By similarity
Active sitei195 – 1951Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Protein family/group databases

MEROPSiS01.437.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin B (EC:3.4.21.1)
Cleaved into the following 2 chains:
OrganismiGadus morhua (Atlantic cod)
Taxonomic identifieri8049 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1313Chymotrypsin B chain A
PRO_0000027647Add
BLAST
Propeptidei14 – 152
PRO_0000027648
Chaini16 – 245230Chymotrypsin B chain B
PRO_0000027649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi1 ↔ 121 By similarity
Disulfide bondi42 ↔ 58 By similarity
Disulfide bondi135 ↔ 201 By similarity
Disulfide bondi167 ↔ 182 By similarity
Disulfide bondi191 ↔ 220 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP80646.
SMRiP80646. Positions 1-245.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 243228Peptidase S1
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Phylogenomic databases

GeneTreeiENSGT00730000110306.
HOVERGENiHBG013304.
OrthoDBiEOG7MKW6Q.
TreeFamiTF330455.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80646-1 [UniParc]FASTAAdd to Basket

« Hide

CGSPAIQPQV TGYARIVNGE EAVPHSWPWQ VSLQQSNGFH FCGGSLINEN    50
WVVTAAHCNV RTYHRVIVGE HDKASDENIQ ILKPSMVFTH PKWDSRTINN 100
DISLIKLASP AVLGTNVSPV CLGESSDVFA PGMKCVTSGW GLTRYNAPGT 150
PNKLQQAALP LMSNEECSQT WGNNMISDVM ICAGAAGATS CMGDSGGPLV 200
CQKDNVWTLV GIVSWGSSRC SVTTPAVYAR VTELRGWVDQ ILAAN 245
Length:245
Mass (Da):26,260
Last modified:October 1, 1996 - v1
Checksum:i74FE0D425517AB02
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 113QVT → VIS AA sequence 1 Publication
Sequence conflicti26 – 261S → T AA sequence 1 Publication
Sequence conflicti28 – 292PW → Y AA sequence 1 Publication

Genome annotation databases

EnsembliENSGMOT00000010525; ENSGMOP00000010246; ENSGMOG00000009511.
ENSGMOT00000010541; ENSGMOP00000010261; ENSGMOG00000009511.

Cross-referencesi

3D structure databases

ProteinModelPortali P80646.
SMRi P80646. Positions 1-245.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.437.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGMOT00000010525 ; ENSGMOP00000010246 ; ENSGMOG00000009511 .
ENSGMOT00000010541 ; ENSGMOP00000010261 ; ENSGMOG00000009511 .

Phylogenomic databases

GeneTreei ENSGT00730000110306.
HOVERGENi HBG013304.
OrthoDBi EOG7MKW6Q.
TreeFami TF330455.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: PROTEIN SEQUENCE.
    Tissue: Pyloric caecum.
  2. "Structural and kinetic properties of chymotrypsin from Atlantic cod (Gadus morhua). Comparison with bovine chymotrypsin."
    Asgeirsson B., Bjarnason J.B.
    Comp. Biochem. Physiol. 99B:327-335(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-12 AND 16-31.
    Tissue: Pyloric caecum.

Entry informationi

Entry nameiCTRB_GADMO
AccessioniPrimary (citable) accession number: P80646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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