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Protein

FMN reductase (NADPH)

Gene

ssuE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes an NADPH-dependent reduction of FMN, but is also able to reduce FAD or riboflavin.

Catalytic activityi

FMNH2 + NADP+ = FMN + NADPH.

GO - Molecular functioni

  • FMN reductase (NADPH) activity Source: UniProtKB-EC
  • FMN reductase activity Source: EcoCyc

GO - Biological processi

  • alkanesulfonate catabolic process Source: EcoCyc
  • cellular response to DNA damage stimulus Source: EcoliWiki
  • cellular response to sulfate starvation Source: EcoCyc
  • protein homotetramerization Source: EcoCyc

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN, NADP

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-146
MetaCyc:MONOMER0-146
BRENDAi1.5.1.38 2026

Names & Taxonomyi

Protein namesi
Recommended name:
FMN reductase (NADPH) (EC:1.5.1.38)
Alternative name(s):
FMN reductase
Sulfate starvation-induced protein 4
Short name:
SSI4
Gene namesi
Name:ssuE
Synonyms:ycbP
Ordered Locus Names:b0937, JW0920
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13708 ssuE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001605911 – 191FMN reductase (NADPH)Add BLAST191

Proteomic databases

PaxDbiP80644
PRIDEiP80644

Expressioni

Inductioni

Repressed by sulfate or cysteine.

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
ssuDP806452EBI-1121047,EBI-561637

Protein-protein interaction databases

BioGridi4262118, 30 interactors
DIPiDIP-10929N
IntActiP80644, 5 interactors
STRINGi316385.ECDH10B_1007

Structurei

Secondary structure

1191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Beta strandi10 – 13Combined sources4
Helixi15 – 29Combined sources15
Beta strandi33 – 38Combined sources6
Helixi39 – 41Combined sources3
Helixi44 – 48Combined sources5
Helixi55 – 66Combined sources12
Beta strandi68 – 75Combined sources8
Helixi83 – 90Combined sources8
Turni94 – 99Combined sources6
Beta strandi101 – 110Combined sources10
Helixi111 – 115Combined sources5
Helixi116 – 119Combined sources4
Helixi121 – 127Combined sources7
Beta strandi131 – 134Combined sources4
Beta strandi137 – 140Combined sources4
Helixi141 – 143Combined sources3
Beta strandi144 – 150Combined sources7
Helixi155 – 172Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PTYX-ray2.10A/B/C/D1-191[»]
4PTZX-ray1.90A/B/C/D1-191[»]
4PU0X-ray2.30A/B/C/D1-191[»]
ProteinModelPortaliP80644
SMRiP80644
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SsuE family.Curated

Phylogenomic databases

eggNOGiENOG4108UZX Bacteria
COG0431 LUCA
HOGENOMiHOG000263120
InParanoidiP80644
KOiK00299
OMAiPIYKASY
PhylomeDBiP80644

Family and domain databases

Gene3Di3.40.50.360, 1 hit
InterProiView protein in InterPro
IPR029039 Flavoprotein-like_sf
IPR005025 FMN_Rdtase-like
IPR020048 NADPH-dep_FMN_reduc_SsuE
PfamiView protein in Pfam
PF03358 FMN_red, 1 hit
SUPFAMiSSF52218 SSF52218, 1 hit
TIGRFAMsiTIGR03567 FMN_reduc_SsuE, 1 hit

Sequencei

Sequence statusi: Complete.

P80644-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVITLAGSP RFPSRSSSLL EYAREKLNGL DVEVYHWNLQ NFAPEDLLYA
60 70 80 90 100
RFDSPALKTF TEQLQQADGL IVATPVYKAA YSGALKTLLD LLPERALQGK
110 120 130 140 150
VVLPLATGGT VAHLLAVDYA LKPVLSALKA QEILHGVFAD DSQVIDYHHR
160 170 180 190
PQFTPNLQTR LDTALETFWQ ALHRRDVQVP DLLSLRGNAH A
Length:191
Mass (Da):21,253
Last modified:November 1, 1997 - v2
Checksum:i2371808C97CEE532
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237695 Genomic DNA Translation: CAB40389.1
U00096 Genomic DNA Translation: AAC74023.1
AP009048 Genomic DNA Translation: BAA35692.1
PIRiH64833
RefSeqiNP_415457.1, NC_000913.3
WP_001263933.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74023; AAC74023; b0937
BAA35692; BAA35692; BAA35692
GeneIDi945947
KEGGiecj:JW0920
eco:b0937
PATRICifig|1411691.4.peg.1337

Similar proteinsi

Entry informationi

Entry nameiSSUE_ECOLI
AccessioniPrimary (citable) accession number: P80644
Secondary accession number(s): P75854
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health