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Protein

Acyl carrier protein

Gene

acpA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBSUB:BSU15920-MONOMER
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier proteinUniRule annotation
Short name:
ACPUniRule annotation
Gene namesi
Name:acpA
Synonyms:acpP
Ordered Locus Names:BSU15920
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001801041 – 77Acyl carrier proteinAdd BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1 Publication1

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDbiP80643
PRIDEiP80643

Interactioni

Protein-protein interaction databases

IntActiP80643, 2 interactors
STRINGi224308.Bsubs1_010100008781

Structurei

Secondary structure

177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 15Combined sources13
Helixi20 – 22Combined sources3
Beta strandi25 – 27Combined sources3
Helixi29 – 32Combined sources4
Helixi39 – 50Combined sources12
Helixi57 – 62Combined sources6
Helixi66 – 72Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F80X-ray2.30D/E/F2-77[»]
1HY8NMR-A2-77[»]
2X2BX-ray2.69A1-77[»]
ProteinModelPortaliP80643
SMRiP80643
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80643

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 77CarrierPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the acyl carrier protein (ACP) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105VNB Bacteria
COG0236 LUCA
HOGENOMiHOG000178184
InParanoidiP80643
KOiK02078
OMAiDQIKPES
PhylomeDBiP80643

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
HAMAPiMF_01217 Acyl_carrier, 1 hit
InterProiView protein in InterPro
IPR036736 ACP-like_sf
IPR003231 Acyl_carrier
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00550 PP-binding, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000887 PD000887, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
TIGRFAMsiTIGR00517 acyl_carrier, 1 hit
PROSITEiView protein in PROSITE
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit

Sequencei

Sequence statusi: Complete.

P80643-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTLERVTK IIVDRLGVDE ADVKLEASFK EDLGADSLDV VELVMELEDE
60 70
FDMEISDEDA EKIATVGDAV NYIQNQQ
Length:77
Mass (Da):8,591
Last modified:October 1, 1996 - v1
Checksum:i75E745DE3C6A0951
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59433 Genomic DNA Translation: AAC44308.1
D64116 Genomic DNA Translation: BAA10975.1
AL009126 Genomic DNA Translation: CAB13465.1
PIRiJC4822
T46634
RefSeqiNP_389474.1, NC_000964.3
WP_003154310.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB13465; CAB13465; BSU15920
GeneIDi938486
9778756
KEGGibsu:BSU15920
PATRICifig|224308.179.peg.1732

Similar proteinsi

Entry informationi

Entry nameiACP_BACSU
AccessioniPrimary (citable) accession number: P80643
Secondary accession number(s): P51832
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health