ID   G6PD_MAIZE              Reviewed;          15 AA.
AC   P80619;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   24-JAN-2024, entry version 66.
DE   RecName: Full=Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform;
DE            Short=G6PD;
DE            EC=1.1.1.49 {ECO:0000250|UniProtKB:Q9LK23};
DE   AltName: Full=2D-page of etiolated coleoptile spot 243;
DE   Flags: Fragment;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Coleoptile;
RX   AGRICOLA=IND20551642; DOI=10.1007/BF00224104;
RA   Touzet P., Riccardi F., Morin C., Damerval C., Huet J.-C., Pernollet J.-C.,
RA   Zivy M., de Vienne D.;
RT   "The maize two dimensional gel protein database: towards an integrated
RT   genome analysis program.";
RL   Theor. Appl. Genet. 93:997-1005(1996).
CC   -!- FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-
CC       phosphate pathway, which represents a route for the dissimilation of
CC       carbohydrates besides glycolysis. The main function of this enzyme is
CC       to provide reducing power (NADPH) and pentose phosphates for fatty acid
CC       and nucleic acid synthesis (By similarity).
CC       {ECO:0000250|UniProtKB:Q9LK23}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-
CC         lactone + H(+) + NADPH; Xref=Rhea:RHEA:15841, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:57955, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:61548; EC=1.1.1.49;
CC         Evidence={ECO:0000250|UniProtKB:Q9LK23};
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC       1/3. {ECO:0000305}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9LK23}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9LK23}.
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase family.
CC       {ECO:0000305}.
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DR   STRING; 4577.P80619; -.
DR   MaizeGDB; 123946; -.
DR   InParanoid; P80619; -.
DR   UniPathway; UPA00115; UER00408.
DR   Proteomes; UP000007305; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Cytoplasm; Direct protein sequencing;
KW   Glucose metabolism; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           <1..>15
FT                   /note="Glucose-6-phosphate 1-dehydrogenase, cytoplasmic
FT                   isoform"
FT                   /id="PRO_0000068099"
FT   BINDING         11
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10005"
FT   NON_TER         1
FT   NON_TER         15
SQ   SEQUENCE   15 AA;  1741 MW;  02038EE7471AE038 CRC64;
     XGRNEFVIRL QXSEA
//