P80593 (MT_RUTRU) Reviewed, UniProtKB/Swiss-Prot
Last modified
March 6, 2013.
Version 55.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Metallothionein Short name=MT | ||
| Gene names |
| ||
| Organism | Rutilus rutilus (Roach) | ||
| Taxonomic identifier | 48668 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Rutilus |
Protein attributes
| Sequence length | 60 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity. |
| Domain | Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Metal-thiolate cluster |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Molecular_function | metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 60 | 60 | Metallothionein | PRO_0000197311 | |||||
Regions | |||||||||
| Region | 1 – 28 | 28 | Beta | ||||||
| Region | 29 – 60 | 32 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 4 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 6 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 12 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 14 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 18 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 20 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 23 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 25 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 28 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 32 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 33 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 35 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 36 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 40 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 43 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 47 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 49 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 54 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 58 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 59 | 1 | Divalent metal cation; cluster A | ||||||
Sequences
References
| [1] | "Isolation and structural characterization of hepatic metallothionein from the roach (Rutilus rutilus)." Grumiaux F., Bulet P., Salzet M., Demuynck S., Dhainaut-Courtois N. Fish Physiol. Biochem. 19:279-286(1998) Cited for: PROTEIN SEQUENCE. Tissue: Liver. |
Cross-references
3D structure databases | |
|---|---|
| ProteinModelPortal | P80593. |
| SMR | P80593. Positions 2-29, 31-60. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| HOVERGEN | HBG009063. |
Family and domain databases | |
| Gene3D | 4.10.10.10. 1 hit. |
| InterPro | IPR017854. Metalthion_dom. IPR023587. Metalthion_dom_vert. IPR003019. Metalthion_sfam_euk. IPR000006. Metalthion_vert. IPR018064. Metalthion_vert_metal_BS. [Graphical view] |
| PANTHER | PTHR23299. PTHR23299. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| SUPFAM | SSF57868. Metallothionein_sfam. 1 hit. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MT_RUTRU | ||||||||
| Accession | Primary (citable) accession number: P80593 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |