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Protein

Hexokinase

Gene

hxkA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathway: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase (EC:2.7.1.1)
Gene namesi
Name:hxkA
ORF Names:AN7459
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560 Componenti: Chromosome IV

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490HexokinasePRO_0000197607Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00000552.

Structurei

3D structure databases

ProteinModelPortaliP80581.
SMRiP80581. Positions 18-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 466446HexokinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni75 – 209135Hexokinase small subdomainPROSITE-ProRule annotationAdd
BLAST
Regioni210 – 455246Hexokinase large subdomainPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated
Contains 1 hexokinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiP80581.
KOiK00844.
OMAiDICQSKY.
OrthoDBiEOG79SF68.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGVGPKRPP SRKGSMSDVP QNLLEHIKHF EEIFTVDTAT LKKIVDHFVN
60 70 80 90 100
ELTKGLSVEG GNIPMNVTWV LGFPDGKETG TFLALDMGGT NLRVCEITLT
110 120 130 140 150
EEKGGFDIIQ SKYRMPEELK TGEAEELWQY IVDCVEQFIQ FHHENENLSK
160 170 180 190 200
LPLGFTFSYP ATQDYIDHGV LQRWTKGFDI DGVEGKDVVP PLEKVFKERG
210 220 230 240 250
LPIKVAALIN DTTGTLIASS YTDPAMKIGC IFGTGVNAAY MENAGSIPKL
260 270 280 290 300
AHMNLPPDMP VAINCEYGAF DNEHIVLPLT KYDHIIDRDS PRPGQQAFEK
310 320 330 340 350
MTAGLYLGEI FRLALVDILD TQPGLIFKDQ DTSQLRIPYL LDSSFPAAIE
360 370 380 390 400
EDPYENLIET AELVQNMLKI KATRSELELM RRLAELIGTR AARLSACGVA
410 420 430 440 450
AICKKKNIES CHVGADGSVF TKYPHFKARG AQALREILDW APSEKDKVTI
460 470 480 490
HAAEDGSGVG AALIAALTLK RVKAGNTAGI RDAQAMLAMC
Length:490
Mass (Da):53,925
Last modified:May 26, 2009 - v2
Checksum:i2CA2F7F97B680812
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000129 Genomic DNA. Translation: EAA62039.1.
BN001304 Genomic DNA. Translation: CBF79423.1.
RefSeqiXP_680728.1. XM_675636.1.

Genome annotation databases

EnsemblFungiiCADANIAT00000552; CADANIAP00000552; CADANIAG00000552.
GeneIDi2869351.
KEGGiani:AN7459.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000129 Genomic DNA. Translation: EAA62039.1.
BN001304 Genomic DNA. Translation: CBF79423.1.
RefSeqiXP_680728.1. XM_675636.1.

3D structure databases

ProteinModelPortaliP80581.
SMRiP80581. Positions 18-482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00000552.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00000552; CADANIAP00000552; CADANIAG00000552.
GeneIDi2869351.
KEGGiani:AN7459.2.

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiP80581.
KOiK00844.
OMAiDICQSKY.
OrthoDBiEOG79SF68.

Enzyme and pathway databases

UniPathwayiUPA00242.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "Characterisation of the Aspergillus nidulans frA1 mutant: hexose phosphorylation and apparent lack of involvement of hexokinase in glucose repression."
    Ruijter G.J.G., Panneman H., van den Broeck H.C., Bennett J.M., Visser J.
    FEMS Microbiol. Lett. 139:223-228(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 210-331.
    Strain: biA1.

Entry informationi

Entry nameiHXK_EMENI
AccessioniPrimary (citable) accession number: P80581
Secondary accession number(s): C8VBD5, Q5AW71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 26, 2009
Last modified: June 24, 2015
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.