P80581 (HXK_EMENI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hexokinase
EC=2.7.1.1

Gene names

Name:	hxkA
ORF Names:	AN7459

Organism

Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

Taxonomic identifier

227321 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + D-hexose = ADP + D-hexose 6-phosphate.
Pathway	Carbohydrate metabolism; hexose metabolism.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the hexokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Allosteric enzyme Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Hexokinase		PRO_0000197607

Sequences

	Sequence		Length	Mass (Da)
	P80581 [UniParc]. Last modified May 26, 2009. Version 2. Checksum: 2CA2F7F97B680812	FASTA	490	53,925
	10 20 30 40 50 60 MVGVGPKRPP SRKGSMSDVP QNLLEHIKHF EEIFTVDTAT LKKIVDHFVN ELTKGLSVEG 70 80 90 100 110 120 GNIPMNVTWV LGFPDGKETG TFLALDMGGT NLRVCEITLT EEKGGFDIIQ SKYRMPEELK 130 140 150 160 170 180 TGEAEELWQY IVDCVEQFIQ FHHENENLSK LPLGFTFSYP ATQDYIDHGV LQRWTKGFDI 190 200 210 220 230 240 DGVEGKDVVP PLEKVFKERG LPIKVAALIN DTTGTLIASS YTDPAMKIGC IFGTGVNAAY 250 260 270 280 290 300 MENAGSIPKL AHMNLPPDMP VAINCEYGAF DNEHIVLPLT KYDHIIDRDS PRPGQQAFEK 310 320 330 340 350 360 MTAGLYLGEI FRLALVDILD TQPGLIFKDQ DTSQLRIPYL LDSSFPAAIE EDPYENLIET 370 380 390 400 410 420 AELVQNMLKI KATRSELELM RRLAELIGTR AARLSACGVA AICKKKNIES CHVGADGSVF 430 440 450 460 470 480 TKYPHFKARG AQALREILDW APSEKDKVTI HAAEDGSGVG AALIAALTLK RVKAGNTAGI 490 RDAQAMLAMC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed: 16372000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[2]	"The 2008 update of the Aspergillus nidulans genome annotation: a community effort." Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G. Fungal Genet. Biol. 46:S2-13(2009) [PubMed: 19146970] [Abstract] Cited for: GENOME REANNOTATION. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[3]	"Characterisation of the Aspergillus nidulans frA1 mutant: hexose phosphorylation and apparent lack of involvement of hexokinase in glucose repression." Ruijter G.J.G., Panneman H., van den Broeck H.C., Bennett J.M., Visser J. FEMS Microbiol. Lett. 139:223-228(1996) [PubMed: 8674991] [Abstract] Cited for: PROTEIN SEQUENCE OF 210-331. Strain: biA1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACD01000129 Genomic DNA. Translation: EAA62039.1. BN001304 Genomic DNA. Translation: CBF79423.1.
RefSeq	XP_680728.1. XM_675636.1.
3D structure databases
ProteinModelPortal	P80581.
SMR	P80581. Positions 18-482.
ModBase	Search...
Protein-protein interaction databases
STRING	P80581.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADANIAT00000552; CADANIAP00000552; CADANIAG00000552.
GeneID	2869351.
KEGG	ani:AN7459.2.
Phylogenomic databases
OMA	TKHFISE.
OrthoDB	EOG4F21BM.
PhylomeDB	P80581.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR019807. Hexokinase_CS. IPR022672. Hexokinase_N. [Graphical view]
KO	K00844.
PANTHER	PTHR19443. Hexokinase. 1 hit.
Pfam	PF00349. Hexokinase_1. 1 hit. PF03727. Hexokinase_2. 1 hit. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXK_EMENI

Accession

Primary (citable) accession number: P80581
Secondary accession number(s): C8VBD5, Q5AW71

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program