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P80581

- HXK_EMENI

UniProt

P80581 - HXK_EMENI

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Protein

Hexokinase

Gene

hxkA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fructokinase activity Source: ASPGD
  3. glucokinase activity Source: ASPGD
  4. hexokinase activity Source: ASPGD

GO - Biological processi

  1. carbohydrate phosphorylation Source: ASPGD
  2. cellular response to starvation Source: ASPGD
  3. glucose 6-phosphate metabolic process Source: GOC
  4. glycolytic process Source: UniProtKB-KW
  5. hexose metabolic process Source: UniProtKB-UniPathway
  6. regulation of proteolysis Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase (EC:2.7.1.1)
Gene namesi
Name:hxkA
ORF Names:AN7459
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome IV

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: ASPGD
  2. nucleus Source: ASPGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490HexokinasePRO_0000197607Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00000552.

Structurei

3D structure databases

ProteinModelPortaliP80581.
SMRiP80581. Positions 18-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 223202Hexokinase type-1Add
BLAST
Domaini227 – 469243Hexokinase type-2Add
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.Curated
Contains 1 hexokinase type-1 domain.Curated
Contains 1 hexokinase type-2 domain.Curated

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiP80581.
KOiK00844.
OMAiPEMKIGC.
OrthoDBiEOG79SF68.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80581-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGVGPKRPP SRKGSMSDVP QNLLEHIKHF EEIFTVDTAT LKKIVDHFVN
60 70 80 90 100
ELTKGLSVEG GNIPMNVTWV LGFPDGKETG TFLALDMGGT NLRVCEITLT
110 120 130 140 150
EEKGGFDIIQ SKYRMPEELK TGEAEELWQY IVDCVEQFIQ FHHENENLSK
160 170 180 190 200
LPLGFTFSYP ATQDYIDHGV LQRWTKGFDI DGVEGKDVVP PLEKVFKERG
210 220 230 240 250
LPIKVAALIN DTTGTLIASS YTDPAMKIGC IFGTGVNAAY MENAGSIPKL
260 270 280 290 300
AHMNLPPDMP VAINCEYGAF DNEHIVLPLT KYDHIIDRDS PRPGQQAFEK
310 320 330 340 350
MTAGLYLGEI FRLALVDILD TQPGLIFKDQ DTSQLRIPYL LDSSFPAAIE
360 370 380 390 400
EDPYENLIET AELVQNMLKI KATRSELELM RRLAELIGTR AARLSACGVA
410 420 430 440 450
AICKKKNIES CHVGADGSVF TKYPHFKARG AQALREILDW APSEKDKVTI
460 470 480 490
HAAEDGSGVG AALIAALTLK RVKAGNTAGI RDAQAMLAMC
Length:490
Mass (Da):53,925
Last modified:May 26, 2009 - v2
Checksum:i2CA2F7F97B680812
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000129 Genomic DNA. Translation: EAA62039.1.
BN001304 Genomic DNA. Translation: CBF79423.1.
RefSeqiXP_680728.1. XM_675636.1.

Genome annotation databases

EnsemblFungiiCADANIAT00000552; CADANIAP00000552; CADANIAG00000552.
GeneIDi2869351.
KEGGiani:AN7459.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000129 Genomic DNA. Translation: EAA62039.1 .
BN001304 Genomic DNA. Translation: CBF79423.1 .
RefSeqi XP_680728.1. XM_675636.1.

3D structure databases

ProteinModelPortali P80581.
SMRi P80581. Positions 18-482.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00000552.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00000552 ; CADANIAP00000552 ; CADANIAG00000552 .
GeneIDi 2869351.
KEGGi ani:AN7459.2.

Phylogenomic databases

eggNOGi COG5026.
HOGENOMi HOG000162670.
InParanoidi P80581.
KOi K00844.
OMAi PEMKIGC.
OrthoDBi EOG79SF68.

Enzyme and pathway databases

UniPathwayi UPA00242 .

Family and domain databases

InterProi IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view ]
PANTHERi PTHR19443. PTHR19443. 1 hit.
Pfami PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view ]
PRINTSi PR00475. HEXOKINASE.
PROSITEi PS00378. HEXOKINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "Characterisation of the Aspergillus nidulans frA1 mutant: hexose phosphorylation and apparent lack of involvement of hexokinase in glucose repression."
    Ruijter G.J.G., Panneman H., van den Broeck H.C., Bennett J.M., Visser J.
    FEMS Microbiol. Lett. 139:223-228(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 210-331.
    Strain: biA1.

Entry informationi

Entry nameiHXK_EMENI
AccessioniPrimary (citable) accession number: P80581
Secondary accession number(s): C8VBD5, Q5AW71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3