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P80581

- HXK_EMENI

UniProt

P80581 - HXK_EMENI

Protein

Hexokinase

Gene

hxkA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + D-hexose = ADP + D-hexose 6-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. fructokinase activity Source: ASPGD
    3. glucokinase activity Source: ASPGD
    4. hexokinase activity Source: ASPGD

    GO - Biological processi

    1. carbohydrate phosphorylation Source: ASPGD
    2. cellular response to starvation Source: ASPGD
    3. glucose 6-phosphate metabolic process Source: GOC
    4. glycolytic process Source: UniProtKB-KW
    5. hexose metabolic process Source: UniProtKB-UniPathway
    6. regulation of proteolysis Source: ASPGD

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00242.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hexokinase (EC:2.7.1.1)
    Gene namesi
    Name:hxkA
    ORF Names:AN7459
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome IV

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: ASPGD
    2. nucleus Source: ASPGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490HexokinasePRO_0000197607Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00000552.

    Structurei

    3D structure databases

    ProteinModelPortaliP80581.
    SMRiP80581. Positions 18-482.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 223202Hexokinase type-1Add
    BLAST
    Domaini227 – 469243Hexokinase type-2Add
    BLAST

    Sequence similaritiesi

    Belongs to the hexokinase family.Curated
    Contains 1 hexokinase type-1 domain.Curated
    Contains 1 hexokinase type-2 domain.Curated

    Phylogenomic databases

    eggNOGiCOG5026.
    HOGENOMiHOG000162670.
    KOiK00844.
    OMAiPEMKIGC.
    OrthoDBiEOG79SF68.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.
    PROSITEiPS00378. HEXOKINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P80581-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGVGPKRPP SRKGSMSDVP QNLLEHIKHF EEIFTVDTAT LKKIVDHFVN    50
    ELTKGLSVEG GNIPMNVTWV LGFPDGKETG TFLALDMGGT NLRVCEITLT 100
    EEKGGFDIIQ SKYRMPEELK TGEAEELWQY IVDCVEQFIQ FHHENENLSK 150
    LPLGFTFSYP ATQDYIDHGV LQRWTKGFDI DGVEGKDVVP PLEKVFKERG 200
    LPIKVAALIN DTTGTLIASS YTDPAMKIGC IFGTGVNAAY MENAGSIPKL 250
    AHMNLPPDMP VAINCEYGAF DNEHIVLPLT KYDHIIDRDS PRPGQQAFEK 300
    MTAGLYLGEI FRLALVDILD TQPGLIFKDQ DTSQLRIPYL LDSSFPAAIE 350
    EDPYENLIET AELVQNMLKI KATRSELELM RRLAELIGTR AARLSACGVA 400
    AICKKKNIES CHVGADGSVF TKYPHFKARG AQALREILDW APSEKDKVTI 450
    HAAEDGSGVG AALIAALTLK RVKAGNTAGI RDAQAMLAMC 490
    Length:490
    Mass (Da):53,925
    Last modified:May 26, 2009 - v2
    Checksum:i2CA2F7F97B680812
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000129 Genomic DNA. Translation: EAA62039.1.
    BN001304 Genomic DNA. Translation: CBF79423.1.
    RefSeqiXP_680728.1. XM_675636.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00000552; CADANIAP00000552; CADANIAG00000552.
    GeneIDi2869351.
    KEGGiani:AN7459.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000129 Genomic DNA. Translation: EAA62039.1 .
    BN001304 Genomic DNA. Translation: CBF79423.1 .
    RefSeqi XP_680728.1. XM_675636.1.

    3D structure databases

    ProteinModelPortali P80581.
    SMRi P80581. Positions 18-482.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 162425.CADANIAP00000552.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00000552 ; CADANIAP00000552 ; CADANIAG00000552 .
    GeneIDi 2869351.
    KEGGi ani:AN7459.2.

    Phylogenomic databases

    eggNOGi COG5026.
    HOGENOMi HOG000162670.
    KOi K00844.
    OMAi PEMKIGC.
    OrthoDBi EOG79SF68.

    Enzyme and pathway databases

    UniPathwayi UPA00242 .

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    PROSITEi PS00378. HEXOKINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    3. "Characterisation of the Aspergillus nidulans frA1 mutant: hexose phosphorylation and apparent lack of involvement of hexokinase in glucose repression."
      Ruijter G.J.G., Panneman H., van den Broeck H.C., Bennett J.M., Visser J.
      FEMS Microbiol. Lett. 139:223-228(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 210-331.
      Strain: biA1.

    Entry informationi

    Entry nameiHXK_EMENI
    AccessioniPrimary (citable) accession number: P80581
    Secondary accession number(s): C8VBD5, Q5AW71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3