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P80560

- PTPR2_MOUSE

UniProt

P80560 - PTPR2_MOUSE

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Protein
Receptor-type tyrosine-protein phosphatase N2
Gene
Ptprn2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Implicated in development of nervous system and pancreatic endocrine cells.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei413 – 4142Cleavage By similarity
Binding sitei899 – 8991Substrate By similarity
Active sitei931 – 9311Phosphocysteine intermediate Reviewed prediction
Binding sitei976 – 9761Substrate By similarity

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. negative regulation of GTPase activity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase N2 (EC:3.1.3.48)
Short name:
R-PTP-N2
Alternative name(s):
PTP IA-2beta
Protein tyrosine phosphatase-NP
Short name:
PTP-NP
Gene namesi
Name:Ptprn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:107418. Ptprn2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 600573Extracellular Reviewed prediction
Add
BLAST
Transmembranei601 – 62121Helical; Reviewed prediction
Add
BLAST
Topological domaini622 – 1001380Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. receptor complex Source: MGI
  4. secretory granule Source: MGI
  5. terminal bouton Source: Ensembl
  6. transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Involvement in diseasei

Autoantigen in insulin-dependent diabetes mellitus (IDDM).

Disruption phenotypei

Mild glucose intolerance and impaired glucose-stimulated insulin secretion.1 Publication

Keywords - Diseasei

Diabetes mellitus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 1001974Receptor-type tyrosine-protein phosphatase N2
PRO_0000025456Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi550 – 5501N-linked (GlcNAc...) Reviewed prediction
Modified residuei956 – 9561N6-acetyllysine By similarity

Post-translational modificationi

Appears to undergo multiple proteolytic cleavage at consecutive basic residues By similarity.

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

MaxQBiP80560.
PaxDbiP80560.
PRIDEiP80560.

PTM databases

PhosphoSiteiP80560.

Expressioni

Tissue specificityi

Pancreas and brain.

Developmental stagei

Expressed in early stages of pancreatic development. First expressed in day 8.5 embryos (E8.5) in the dorsal part of the midgut endoderm and by E9.5, in the pancreatic rudiment specifically in early endocrine progenitor cells. At later stages expressed in insulin- or glucagon-producing cells. During neural development, the type 2 PTP-NP is expressed in early stages of neurogenesis, and the type 1 weakly in the later stages.

Gene expression databases

BgeeiP80560.
GenevestigatoriP80560.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PtprnQ606734EBI-8538944,EBI-8328895

Protein-protein interaction databases

IntActiP80560. 2 interactions.
MINTiMINT-8310377.
STRINGi10090.ENSMUSP00000064046.

Structurei

3D structure databases

ProteinModelPortaliP80560.
SMRiP80560. Positions 497-583, 710-996.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini731 – 991261Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni931 – 9377Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00750000117312.
HOGENOMiHOG000243992.
HOVERGENiHBG105788.
InParanoidiQ1RLJ1.
KOiK07817.
OMAiYRYEVSP.
OrthoDBiEOG7K9K30.
TreeFamiTF351976.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR021613. Receptor_IA-2_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF11548. Receptor_IA-2. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P80560-1) [UniParc]FASTAAdd to Basket

Also known as: Type 1-PTP-NP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGPPLPLLLL LLLPPPLPRA LPAPASARGR QLPGRLGCLF EDGLCGSLET     50
CVNDGVFGRC QKVPVMDTYR YEVPPGALLH LKVTLQKLSR TGFTWQDDYT 100
QRVIAQELAN LPKAYLWHGE ASGPARSLQQ NADNEKWFSL EREVALAKTL 150
RRYLPYLELL SQTPTANAHS RIDHETRPAK GEDSSPENIL TYVAHTSALT 200
YPPATRAKYP DNLLRPFSRL QPDELSPKVD GDIDKQKLIA ALGAYTAQRL 250
PGENDPEPRY LVHGSARAPR PFSATALSQR WPPPPGDAKD SPSMDDDTLL 300
QSLLKDLQQN SEVDRLGPLK EEKADSVAGA IQSDPAEGSQ ESHGRGAEGQ 350
PREQTDAPET MLQDHRLSEV DDPVYKEVNR LSFQLGDLLK DYGSPLLPEG 400
PLLEKSSREE IKKSEQPEEV LSSEEETAGV EHVRSRTYSK DLFERKPNSE 450
PQPRRLEDQF QNRAPELWED EESLKLAAQG PPSGGLQLEV QPSEEQQGYI 500
LTGNNPLSPE KGKQLMDQVA HILRVPSSFF ADIKVLGPAV TFKVSANIQN 550
MTTADVIKAA ADNKDQLEKA TGLTILQSGI RPKGKLKLLP HQEEQEDSTK 600
FILLTFLSIA CILGVLLASS LAYCLRHNSH YKLKDKLSGL GADPSADATE 650
AYQELCRQRM AIRPQDRSEG PHTSRINSVS SQFSDGPMPS PSARSSTSSW 700
SEEPVQSNMD ISTGHMILAY MEDHLKNKNR LEKEWEALCA YQAEPNSSLV 750
AQREENAPKN RSLAVLTYDH SRILLKSQNS HGSSDYINAS PIMDHDPRNP 800
AYIATQGPLP ATVADFWQMV WESGCAVIVM LTPLSENGVR QCHHYWPDEG 850
SNLYHVYEVN LVSEHIWCQD FLVRSFYLKN LQTNETRTVT QFHFLSWYDQ 900
GVPSSTRSLL DFRRKVNKCY RGRSCPIIVH CSDGAGRSGT YVLIDMVLNK 950
MAKGAKEIDI AATLEHLRDQ RPGMVQTKEQ FEFALTAVAE EVNAILKALP 1000
Q 1001
Length:1,001
Mass (Da):111,497
Last modified:July 27, 2011 - v2
Checksum:i42B590A13CA89CB8
GO
Isoform 2 (identifier: P80560-2)

Also known as: Type 2-PTP-NP

Sequence is not available
Length:
Mass (Da):

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211A → T in AAB06945. 1 Publication
Sequence conflicti266 – 2661A → S in AAB06945. 1 Publication
Sequence conflicti369 – 3691E → D in AAB06945. 1 Publication
Sequence conflicti370 – 3712Missing in AAB39996. 1 Publication
Sequence conflicti395 – 3951P → H in AAB06945. 1 Publication
Sequence conflicti411 – 4111I → M in AAB39996. 1 Publication
Sequence conflicti414 – 4141S → L in AAB39996. 1 Publication
Sequence conflicti586 – 5861L → H in AAB39996. 1 Publication
Sequence conflicti662 – 6621I → V in AAB06945. 1 Publication
Sequence conflicti662 – 6621I → V in AAB39996. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57345 mRNA. Translation: AAB06945.1.
U82439 mRNA. Translation: AAB39996.1.
BN000315
, BN000293, BN000294, BN000295, BN000296, BN000297, BN000298, BN000299, BN000300, BN000301, BN000302, BN000303, BN000304, BN000305, BN000306, BN000307, BN000308, BN000309, BN000310, BN000311, BN000312, BN000313, BN000314 Genomic DNA. Translation: CAG23871.1.
CCDSiCCDS36576.1. [P80560-1]
RefSeqiNP_035345.2. NM_011215.2. [P80560-1]
UniGeneiMm.206054.

Genome annotation databases

EnsembliENSMUST00000070733; ENSMUSP00000064046; ENSMUSG00000056553. [P80560-1]
GeneIDi19276.
KEGGimmu:19276.
UCSCiuc007phx.2. mouse. [P80560-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57345 mRNA. Translation: AAB06945.1 .
U82439 mRNA. Translation: AAB39996.1 .
BN000315
, BN000293 , BN000294 , BN000295 , BN000296 , BN000297 , BN000298 , BN000299 , BN000300 , BN000301 , BN000302 , BN000303 , BN000304 , BN000305 , BN000306 , BN000307 , BN000308 , BN000309 , BN000310 , BN000311 , BN000312 , BN000313 , BN000314 Genomic DNA. Translation: CAG23871.1 .
CCDSi CCDS36576.1. [P80560-1 ]
RefSeqi NP_035345.2. NM_011215.2. [P80560-1 ]
UniGenei Mm.206054.

3D structure databases

ProteinModelPortali P80560.
SMRi P80560. Positions 497-583, 710-996.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P80560. 2 interactions.
MINTi MINT-8310377.
STRINGi 10090.ENSMUSP00000064046.

PTM databases

PhosphoSitei P80560.

Proteomic databases

MaxQBi P80560.
PaxDbi P80560.
PRIDEi P80560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070733 ; ENSMUSP00000064046 ; ENSMUSG00000056553 . [P80560-1 ]
GeneIDi 19276.
KEGGi mmu:19276.
UCSCi uc007phx.2. mouse. [P80560-1 ]

Organism-specific databases

CTDi 5799.
MGIi MGI:107418. Ptprn2.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00750000117312.
HOGENOMi HOG000243992.
HOVERGENi HBG105788.
InParanoidi Q1RLJ1.
KOi K07817.
OMAi YRYEVSP.
OrthoDBi EOG7K9K30.
TreeFami TF351976.

Miscellaneous databases

NextBioi 296180.
PROi P80560.
SOURCEi Search...

Gene expression databases

Bgeei P80560.
Genevestigatori P80560.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR021613. Receptor_IA-2_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF11548. Receptor_IA-2. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "PTP-NP, a new member of the receptor protein tyrosine phosphatase family, implicated in development of nervous system and pancreatic endocrine cells."
    Chiang M.-K., Flanagan J.G.
    Development 122:2239-2250(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Brain.
  2. "Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment."
    Lu J., Li Q., Xie H., Chen Z.-J., Borovitskaya A.E., Maclaren N.K., Notkins A.L., Lan M.S.
    Proc. Natl. Acad. Sci. U.S.A. 93:2307-2311(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 282-1001.
    Tissue: Neonatal brain.
  3. "Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice."
    Kubosaki A., Gross S., Miura J., Saeki K., Zhu M., Nakamura S., Hendriks W., Notkins A.L.
    Diabetes 53:1684-1691(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, DISRUPTION PHENOTYPE.
    Strain: C57BL/6.

Entry informationi

Entry nameiPTPR2_MOUSE
AccessioniPrimary (citable) accession number: P80560
Secondary accession number(s): O09134, P70328, Q1RLJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi