Reviewed, UniProtKB/Swiss-Prot P80551 (RNAS2_PIG)

Names and origin

Protein names

Recommended name:
    Non-secretory ribonuclease
    EC=3.1.27.5
Alternative name(s):
    Eosinophil-derived neurotoxin

Gene names

Name:

RNASE2

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	20 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U.
Catalytic activity	Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates.
Subcellular location	Lysosome Probable. Cytoplasmic granule. Note: Matrix of eosinophil's large specific granule.
Sequence similarities	Belongs to the pancreatic ribonuclease family.

Ontologies

Keywords
Cellular component	Lysosome
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	pancreatic ribonuclease activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›20	›20	Non-secretory ribonuclease		PRO_0000057160
Sites
	Active site	16	1	Proton acceptor By similarity
Experimental info
	Non-terminal residue	20	1

Sequences

	Sequence		Length	Mass (Da)
	P80551-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 2CD0A6E1ABAE8A6A	FASTA	20	2,145
	10 20 VPPGGLTXAQ XFTIQHIXMT

References

[1]	"Isolation and characterization of porcine cationic eosinophil granule proteins." Fornhem C., Peterson C.G.B., Alving K. Int. Arch. Allergy Immunol. 110:132-142(1996) [PubMed: 8645990] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P80551.
Enzyme and pathway databases
BRENDA	3.1.27.5. 249.
Family and domain databases
InterPro	IPR001427. RNaseA. [Graphical view]
PROSITE	PS00127. RNASE_PANCREATIC. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNAS2_PIG

Accession

Primary (citable) accession number: P80551

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)