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Protein

Fatty acid-binding protein

Gene

SCP2

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the transport of fatty acids. Binds fatty acids and fatty acyl-CoAs including palmitic acid, oleic acid, cis-parinaric acid and palmitoyl-CoA (in vitro).2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BRENDAi2.3.1.154. 1122.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein
Alternative name(s):
Sterol carrier protein 2
YLSCP2
Gene namesi
Name:SCP2
Ordered Locus Names:YALI0E01298g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome E

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 129128Fatty acid-binding proteinPRO_0000097634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Monomer.2 Publications

Structurei

Secondary structure

1
129
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 113Combined sources
Helixi12 – 2211Combined sources
Helixi24 – 263Combined sources
Helixi27 – 3711Combined sources
Beta strandi39 – 468Combined sources
Beta strandi52 – 598Combined sources
Turni60 – 623Combined sources
Beta strandi65 – 717Combined sources
Beta strandi77 – 837Combined sources
Helixi84 – 918Combined sources
Helixi97 – 1026Combined sources
Beta strandi105 – 1106Combined sources
Helixi112 – 1187Combined sources
Helixi121 – 1266Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JGXX-ray2.20A/B1-129[»]
ProteinModelPortaliP80547.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 129120SCP2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi127 – 1293Microbody targeting signal

Sequence similaritiesi

Contains 1 SCP2 domain.Curated

Phylogenomic databases

HOGENOMiHOG000141680.
InParanoidiP80547.
OMAiQFVIKNS.
OrthoDBiEOG7VTF0H.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
InterProiIPR003033. SCP2_sterol-bd_dom.
[Graphical view]
PfamiPF02036. SCP2. 1 hit.
[Graphical view]
SUPFAMiSSF55718. SSF55718. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKVDGFTS SIIFDVIRDG LNDPSQAKQK AESIKKANAI IVFNLKNKAG
60 70 80 90 100
KTESWYLDLK NDGDVGKGNK SPKGDADIQL TLSDDHFQQL VEGKANAQRL
110 120
FMTGKLKVKG NVMKAAAIEG ILKNAQNNL
Length:129
Mass (Da):14,034
Last modified:January 23, 2007 - v4
Checksum:i7DCAC98D27D31E89
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751D → N AA sequence (PubMed:8828794).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ431362 mRNA. Translation: CAD24067.2.
CR382131 Genomic DNA. Translation: CAG78989.1.
RefSeqiXP_503410.1. XM_503410.1.

Genome annotation databases

EnsemblFungiiCAG78989; CAG78989; YALI0_E01298g.
GeneIDi2911748.
KEGGiyli:YALI0E01298g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ431362 mRNA. Translation: CAD24067.2.
CR382131 Genomic DNA. Translation: CAG78989.1.
RefSeqiXP_503410.1. XM_503410.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JGXX-ray2.20A/B1-129[»]
ProteinModelPortaliP80547.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG78989; CAG78989; YALI0_E01298g.
GeneIDi2911748.
KEGGiyli:YALI0E01298g.

Phylogenomic databases

HOGENOMiHOG000141680.
InParanoidiP80547.
OMAiQFVIKNS.
OrthoDBiEOG7VTF0H.

Enzyme and pathway databases

BRENDAi2.3.1.154. 1122.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
InterProiIPR003033. SCP2_sterol-bd_dom.
[Graphical view]
PfamiPF02036. SCP2. 1 hit.
[Graphical view]
SUPFAMiSSF55718. SSF55718. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, CLEAVAGE OF INITIATOR METHIONINE, FUNCTION, SUBUNIT, ACETYLATION AT SER-2.
    Strain: CX-121-1B.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIB 122 / E 150.
  3. "Purification and partial characterization of a fatty acid-binding protein from the yeast, Yarrowia lipolytica."
    Dell'Angelica E.C., Ermacora M.R., Santome J.A.
    Biochem. Mol. Biol. Int. 39:439-445(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 74-81; 101-105 AND 114-129, FUNCTION, SUBUNIT.
    Strain: CX-121-1B.

Entry informationi

Entry nameiSCP2_YARLI
AccessioniPrimary (citable) accession number: P80547
Secondary accession number(s): Q6C7F2, Q8J0I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: November 11, 2015
This is version 77 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Expressed essentially in cells grown on palmitic acid with small amounts found in cells grown on glucose.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.