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P80545

- BLAC_SERFO

UniProt

P80545 - BLAC_SERFO

Protein

Beta-lactamase

Gene
N/A
Organism
Serratia fonticola
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Hydrolyzes broad-spectrum beta-lactam antibiotics. Active against cephalosporins.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.

    Enzyme regulationi

    Inhibited by clavulanic acid, sulbactam and tazobactam.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491Acyl-ester intermediateBy similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-lactam antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Enzyme and pathway databases

    SABIO-RKP80545.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase (EC:3.5.2.6)
    Alternative name(s):
    Penicillinase
    Cleaved into the following 2 chains:
    OrganismiSerratia fonticola
    Taxonomic identifieri47917 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267Beta-lactamase form IPRO_0000017010Add
    BLAST
    Chaini6 – 267262Beta-lactamase form IIPRO_0000017011Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP80545.
    SMRiP80545. Positions 8-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni213 – 2153Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.Curated

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    [Graphical view]
    PRINTSiPR00118. BLACTAMASEA.
    SUPFAMiSSF56601. SSF56601. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80545-1 [UniParc]FASTAAdd to Basket

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    QPANAKANIQ QQLSELEKNS GGRLGVALID TADNSQILYR GDERFPMCST    50
    SKVMAVSALL KQSETDKNLL AKRMEIKQSD LVNYNPIAEK HLDTGMTLAE 100
    FSAATIQYSD NTAMNKILEH LGGPAKVTEF ARTIGDKTFR LDRTEPTLNT 150
    AIPGDKRDTT SPQAMAISLQ NLTLGKALAE PQRAQLVEWM KGNTTGGASI 200
    RAGLPTTWVV GDKTGSGDYG TTNDIAVIWP ANHAPLVLVT YFTQPQQNAE 250
    ARKDVLAAAA KIVTAGL 267
    Length:267
    Mass (Da):28,755
    Last modified:February 1, 1996 - v1
    Checksum:iD70C1FDEE63F09C3
    GO

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P80545.
    SMRi P80545. Positions 8-267.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK P80545.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    [Graphical view ]
    PRINTSi PR00118. BLACTAMASEA.
    SUPFAMi SSF56601. SSF56601. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and amino acid sequence analysis of a new oxyimino cephalosporin-hydrolyzing class A beta-lactamase from Serratia fonticola CUV."
      Peduzzi J., Farzaneh S., Reynaud A., Barthelemy M., Labia R.
      Biochim. Biophys. Acta 1341:58-70(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Strain: CUV.

    Entry informationi

    Entry nameiBLAC_SERFO
    AccessioniPrimary (citable) accession number: P80545
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3