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Protein

Beta-lactamase

Gene
N/A
Organism
Serratia fonticola
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes broad-spectrum beta-lactam antibiotics. Active against cephalosporins.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Enzyme regulationi

Inhibited by clavulanic acid, sulbactam and tazobactam.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49Acyl-ester intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

SABIO-RKP80545.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Cleaved into the following 2 chains:
OrganismiSerratia fonticola
Taxonomic identifieri47917 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000170101 – 267Beta-lactamase form IAdd BLAST267
ChainiPRO_00000170116 – 267Beta-lactamase form IIAdd BLAST262

Structurei

3D structure databases

ProteinModelPortaliP80545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni213 – 215Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QPANAKANIQ QQLSELEKNS GGRLGVALID TADNSQILYR GDERFPMCST
60 70 80 90 100
SKVMAVSALL KQSETDKNLL AKRMEIKQSD LVNYNPIAEK HLDTGMTLAE
110 120 130 140 150
FSAATIQYSD NTAMNKILEH LGGPAKVTEF ARTIGDKTFR LDRTEPTLNT
160 170 180 190 200
AIPGDKRDTT SPQAMAISLQ NLTLGKALAE PQRAQLVEWM KGNTTGGASI
210 220 230 240 250
RAGLPTTWVV GDKTGSGDYG TTNDIAVIWP ANHAPLVLVT YFTQPQQNAE
260
ARKDVLAAAA KIVTAGL
Length:267
Mass (Da):28,755
Last modified:February 1, 1996 - v1
Checksum:iD70C1FDEE63F09C3
GO

Cross-referencesi

3D structure databases

ProteinModelPortaliP80545.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKP80545.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBLAC_SERFO
AccessioniPrimary (citable) accession number: P80545
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.