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P80545 (BLAC_SERFO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Alternative name(s):
Penicillinase

Cleaved into the following 2 chains:

  1. Beta-lactamase form I
  2. Beta-lactamase form II
OrganismSerratia fonticola
Taxonomic identifier47917 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hydrolyzes broad-spectrum beta-lactam antibiotics. Active against cephalosporins.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Enzyme regulation

Inhibited by clavulanic acid, sulbactam and tazobactam.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Molecular functionHydrolase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Beta-lactamase form I
PRO_0000017010
Chain6 – 267262Beta-lactamase form II
PRO_0000017011

Regions

Region213 – 2153Substrate binding By similarity

Sites

Active site491Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P80545 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: D70C1FDEE63F09C3

FASTA26728,755
        10         20         30         40         50         60 
QPANAKANIQ QQLSELEKNS GGRLGVALID TADNSQILYR GDERFPMCST SKVMAVSALL 

        70         80         90        100        110        120 
KQSETDKNLL AKRMEIKQSD LVNYNPIAEK HLDTGMTLAE FSAATIQYSD NTAMNKILEH 

       130        140        150        160        170        180 
LGGPAKVTEF ARTIGDKTFR LDRTEPTLNT AIPGDKRDTT SPQAMAISLQ NLTLGKALAE 

       190        200        210        220        230        240 
PQRAQLVEWM KGNTTGGASI RAGLPTTWVV GDKTGSGDYG TTNDIAVIWP ANHAPLVLVT 

       250        260 
YFTQPQQNAE ARKDVLAAAA KIVTAGL 

« Hide

References

[1]"Characterization and amino acid sequence analysis of a new oxyimino cephalosporin-hydrolyzing class A beta-lactamase from Serratia fonticola CUV."
Peduzzi J., Farzaneh S., Reynaud A., Barthelemy M., Labia R.
Biochim. Biophys. Acta 1341:58-70(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Strain: CUV.

Cross-references

3D structure databases

ProteinModelPortalP80545.
SMRP80545. Positions 8-267.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKP80545.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBLAC_SERFO
AccessionPrimary (citable) accession number: P80545
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families