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P80545

- BLAC_SERFO

UniProt

P80545 - BLAC_SERFO

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Protein

Beta-lactamase

Gene
N/A
Organism
Serratia fonticola
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes broad-spectrum beta-lactam antibiotics. Active against cephalosporins.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Enzyme regulationi

Inhibited by clavulanic acid, sulbactam and tazobactam.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

SABIO-RKP80545.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Cleaved into the following 2 chains:
OrganismiSerratia fonticola
Taxonomic identifieri47917 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Beta-lactamase form IPRO_0000017010Add
BLAST
Chaini6 – 267262Beta-lactamase form IIPRO_0000017011Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP80545.
SMRiP80545. Positions 8-267.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni213 – 2153Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80545-1 [UniParc]FASTAAdd to Basket

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QPANAKANIQ QQLSELEKNS GGRLGVALID TADNSQILYR GDERFPMCST    50
SKVMAVSALL KQSETDKNLL AKRMEIKQSD LVNYNPIAEK HLDTGMTLAE 100
FSAATIQYSD NTAMNKILEH LGGPAKVTEF ARTIGDKTFR LDRTEPTLNT 150
AIPGDKRDTT SPQAMAISLQ NLTLGKALAE PQRAQLVEWM KGNTTGGASI 200
RAGLPTTWVV GDKTGSGDYG TTNDIAVIWP ANHAPLVLVT YFTQPQQNAE 250
ARKDVLAAAA KIVTAGL 267
Length:267
Mass (Da):28,755
Last modified:February 1, 1996 - v1
Checksum:iD70C1FDEE63F09C3
GO

Cross-referencesi

3D structure databases

ProteinModelPortali P80545.
SMRi P80545. Positions 8-267.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK P80545.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Characterization and amino acid sequence analysis of a new oxyimino cephalosporin-hydrolyzing class A beta-lactamase from Serratia fonticola CUV."
    Peduzzi J., Farzaneh S., Reynaud A., Barthelemy M., Labia R.
    Biochim. Biophys. Acta 1341:58-70(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Strain: CUV.

Entry informationi

Entry nameiBLAC_SERFO
AccessioniPrimary (citable) accession number: P80545
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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