Reviewed, UniProtKB/Swiss-Prot P80540 (MDH_ACIDE)

Names and origin

Protein names

Recommended name:
    Malate dehydrogenase
    EC=1.1.1.37

Gene names

Name:

mdh

Organism

Acidovorax delafieldii

Taxonomic identifier

47920 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	17 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.
Catalytic activity	(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP MF_01517
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the LDH/MDH superfamily. MDH type 2 family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›17	›17	Malate dehydrogenase HAMAP MF_01517		PRO_0000113344
Regions
	Nucleotide binding	11 – 17	7	NAD By similarity
Experimental info
	Non-terminal residue	17	1

Sequences

	Sequence		Length	Mass (Da)
	P80540-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 110E8111A516909E	FASTA	17	1,663
	10 XKKPVRVAVT GAAGQIG

References

[1]

"Structural studies of malate dehydrogenases (MDHs): MDHs in Brevundimonas species are the first reported MDHs in Proteobacteria which resemble lactate dehydrogenases in primary structure." Charnock C. J. Bacteriol. 179:4066-4070(1997) [PubMed: 9190829] [Abstract] Cited for: PROTEIN SEQUENCE. Strain: CCUG 12929.

Cross-references

3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.37. 298367.
Family and domain databases
HAMAP	MF_01517. [Tree]
InterPro	IPR001252. Malate_DH_AS. [Graphical view]
PROSITE	PS00068. MDH. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MDH_ACIDE

Accession

Primary (citable) accession number: P80540

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)