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P80532 (CATL3_FASHE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative cathepsin L3

EC=3.4.22.15
Alternative name(s):
Newly excysted juvenile protein 8
OrganismFasciola hepatica (Liver fluke)
Taxonomic identifier6192 [NCBI]
Taxonomic lineageEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaEchinostomidaEchinostomataEchinostomatoideaFasciolidaeFasciola

Protein attributes

Sequence length19 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Thiol protease.

Catalytic activity

Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

Subunit structure

Dimer of a heavy and a light chain linked by disulfide bonds Potential.

Subcellular location

Lysosome Potential.

Developmental stage

Expressed at the newly excysted juvenile stage.

Sequence similarities

Belongs to the peptidase C1 family.

Ontologies

Keywords
   Cellular componentLysosome
   Molecular functionHydrolase
Protease
Thiol protease
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›19›19Putative cathepsin L3
PRO_0000050540

Experimental info

Non-terminal residue191

Sequences

Sequence LengthMass (Da)Tools
P80532 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 53FFB5835EBCB0D7

FASTA192,242
        10 
DVPASIDWRE YGYVTEVKD 

« Hide

References

[1]"Fasciola hepatica: rapid identification of newly excysted juvenile proteins."
Tkalcevic J., Ashman K., Meeusen E.
Biochem. Biophys. Res. Commun. 213:169-174(1995) [PubMed: 7639732] [Abstract]
Cited for: PROTEIN SEQUENCE.

Cross-references

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

PROSITEPS00640. THIOL_PROTEASE_ASN. Partial match.
PS00139. THIOL_PROTEASE_CYS. Partial match.
PS00639. THIOL_PROTEASE_HIS. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCATL3_FASHE
AccessionPrimary (citable) accession number: P80532
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 16, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families