P80523 (PORC_METBF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyruvate synthase subunit porC
EC=1.2.7.1

Alternative name(s):
Pyruvate oxidoreductase gamma chain
Short name=POR
Pyruvic-ferredoxin oxidoreductase subunit gamma

Gene names

Name:	porC
Ordered Locus Names:	Mbar_A1002

Organism

Methanosarcina barkeri (strain Fusaro / DSM 804) [Complete proteome] [HAMAP]

Taxonomic identifier

269797 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain.
Miscellaneous	It also catalyzes the oxidation of 2-oxobutyrate.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Molecular function	pyruvate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 182	182	Pyruvate synthase subunit porC		PRO_0000097128

Sequences

	Sequence		Length	Mass (Da)
	P80523 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: 12FF67E4BBB4DFFB	FASTA	182	19,526
	10 20 30 40 50 60 MKEIRIHGRG GQGSVTAAEM LSVAAFEDGK FSQAFPAFGV ERRGAPVQAF TRINNNPIRL 70 80 90 100 110 120 RSQVYTPDYV IVQDATLLET VDVASGVKDD GIIIVNTTEN PESLKLNTKA RVMTVDATKV 130 140 150 160 170 180 AMDIIGVPIV NTVLLGAFAG ATGEINVESI QHAIRARFSG KVGEKNANAI QKAYKLIRGE EA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes." Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R. J. Bacteriol. 188:7922-7931(2006) [PubMed: 16980466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fusaro / DSM 804.
[2]	"Catalytic properties, molecular composition and sequence alignments of pyruvate: ferredoxin oxidoreductase from the methanogenic archaeon Methanosarcina barkeri (strain Fusaro)." Bock A.-K., Kunow J., Glasemacher J., Schoenheit P. Eur. J. Biochem. 237:35-44(1996) [PubMed: 8620891] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-31.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000099 Genomic DNA. Translation: AAZ69970.1.
PIR	S65418.
RefSeq	YP_304550.1. NC_007355.1.
3D structure databases
ProteinModelPortal	P80523.
ModBase	Search...
Protein-protein interaction databases
STRING	P80523.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3626885.
GenomeReviews	Gene locus Mbar_A1002 in contig CP000099_GR.
KEGG	mba:Mbar_A1002.
NMPDR	fig|269797.3.peg.1013.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG07814.
HOGENOM	HBG553299.
OMA	DYVIVQD.
ProtClustDB	PRK08534.
Enzyme and pathway databases
BioCyc	MBAR269797:MBAR_A1002-MONOMER.
Family and domain databases
InterPro	IPR011894. PorC_KorC. IPR019752. Pyrv/ketoisovalerate_OxRed_cat. IPR002869. Pyrv_flavodox_OxRed_cen. [Graphical view]
Gene3D	G3DSA:3.40.920.10. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
KO	K00172.
Pfam	PF01558. POR. 1 hit. [Graphical view]
SUPFAM	SSF53323. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
TIGRFAMs	TIGR02175. PorC_KorC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PORC_METBF

Accession

Primary (citable) accession number: P80523
Secondary accession number(s): Q46DS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	January 10, 2006
Last modified:	November 16, 2011
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program