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Reviewed, UniProtKB/Swiss-Prot P80512 (ADH1_NAJNA)

Last modified June 16, 2009. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1
OrganismNaja naja (Indian cobra)
Taxonomic identifier35670 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Scleroglossa › Serpentes › Colubroidea › Elapidae › Elapinae › Naja

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Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   PTMAcetylation
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionalcohol dehydrogenase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Alcohol dehydrogenase 1
PRO_0000160676

Regions

Nucleotide binding199 – 2046NAD By similarity
Nucleotide binding293 – 2953NAD By similarity

Sites

Metal binding461Zinc 1; catalytic By similarity
Metal binding671Zinc 1; catalytic By similarity
Metal binding971Zinc 2 By similarity
Metal binding1001Zinc 2 By similarity
Metal binding1031Zinc 2 By similarity
Metal binding1111Zinc 2 By similarity
Metal binding1741Zinc 1; catalytic By similarity
Binding site2231NAD By similarity
Binding site2281NAD By similarity
Binding site3701NAD By similarity

Amino acid modifications

Modified residue11N-acetylserine

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Sequences

Sequence LengthMass (Da)Tools
P80512-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 6EDC9E505631EC13

FASTA37539,955
        10         20         30         40         50         60 
STAGKVIKCK AAIAWELNKP LSIEQIEVAP PKAHEVRIKI LATGVCRSDE HVISGAFRMP 

        70         80         90        100        110        120 
LPMVLGHEAA GVVESVGEGV TCVKPGDKVI PLFAPQCGKC RACQSPKGNL CTSNDLNSGS 

       130        140        150        160        170        180 
GLMPDGTSRF TCKGKSIHHF ISTSTFTEYT VVHENSVVKI DPSAPLEKVC LIGCGFSTGY 

       190        200        210        220        230        240 
GAAMQTAKVE PGSICAVFGL GGVGLSVVMG CKAAGASRII GVDINKDKFA KAKEMGATEC 

       250        260        270        280        290        300 
INPLDFKKPI NEVLFDLTGG EGVDYSFEVI GRTETMISAF TSCHQNLGTS VVVGVPPNAS 

       310        320        330        340        350        360 
MITYNPLMLF TGRTWKGCVF GGWKSKDSVP KLVSDFMQKK FVLDPLITHT LPFEKINEGF 

       370 
DLLRSGKSIR TVLIF

« Hide

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References

[1]"Liver class-I alcohol dehydrogenase isozyme relationships and constant patterns in a variable basic structure. Distinctions from characterization of an ethanol dehydrogenase in cobra, Naja naja."
Shafqat J., Hjelmqvist L., Joernvall H.
Eur. J. Biochem. 236:571-578(1996) [PubMed: 8612631] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Liver.

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Cross-references

Sequence databases

PIRS62640.

3D structure databases

HSSPHSSP built from PDB template 1HT0 based on UniProtKB P00326.
SMRP80512. Positions 1-375.
ModBaseSearch...

Phylogenomic databases

HOVERGENP80512.

Enzyme and pathway databases

BRENDA1.1.1.1. 189325.

Family and domain databases

InterProIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR002328. ADH_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameADH1_NAJNA
AccessionPrimary (citable) accession number: P80512
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents