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P80511

- S10AC_HUMAN

UniProt

P80511 - S10AC_HUMAN

Protein

Protein S100-A12

Gene

S100A12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn2+ from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.4 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi16 – 161Zinc or copper
    Metal bindingi26 – 261Zinc or copper
    Metal bindingi86 – 861Zinc or copper
    Metal bindingi90 – 901Zinc or copper

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi19 – 32141; low affinityPROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi62 – 73122; high affinityPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. copper ion binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. RAGE receptor binding Source: UniProtKB
    5. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cytokine secretion Source: UniProtKB
    2. defense response to bacterium Source: UniProtKB
    3. defense response to fungus Source: UniProtKB
    4. inflammatory response Source: ProtInc
    5. innate immune response Source: UniProtKB
    6. killing of cells of other organism Source: UniProtKB-KW
    7. mast cell activation Source: UniProtKB
    8. monocyte chemotaxis Source: UniProtKB
    9. neutrophil chemotaxis Source: UniProtKB
    10. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    11. positive regulation of inflammatory response Source: UniProtKB
    12. positive regulation of MAP kinase activity Source: UniProtKB
    13. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
    14. xenobiotic metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Fungicide

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Keywords - Ligandi

    Calcium, Copper, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_118563. RIP-mediated NFkB activation via ZBP1.
    REACT_21281. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_24969. TRAF6 mediated NF-kB activation.
    REACT_25195. Advanced glycosylation endproduct receptor signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein S100-A12
    Alternative name(s):
    CGRP
    Calcium-binding protein in amniotic fluid 1
    Short name:
    CAAF1
    Calgranulin-C
    Short name:
    CAGC
    Extracellular newly identified RAGE-binding protein
    Short name:
    EN-RAGE
    Migration inhibitory factor-related protein 6
    Short name:
    MRP-6
    Short name:
    p6
    Neutrophil S100 protein
    S100 calcium-binding protein A12
    Cleaved into the following chain:
    Gene namesi
    Name:S100A12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10489. S100A12.

    Subcellular locationi

    Secreted 1 Publication. Cytoplasm 1 Publication. Cytoplasmcytoskeleton 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
    Note: Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoskeleton Source: UniProtKB
    3. cytosol Source: UniProtKB
    4. extracellular region Source: UniProtKB
    5. nucleus Source: UniProtKB
    6. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34901.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed4 Publications
    Chaini2 – 9291Protein S100-A12PRO_0000045383Add
    BLAST
    Peptidei78 – 9215CalciterminPRO_0000004774Add
    BLAST

    Proteomic databases

    PaxDbiP80511.
    PRIDEiP80511.

    PTM databases

    PhosphoSiteiP80511.

    Expressioni

    Tissue specificityi

    Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high concentrations in the serum of patients suffering from various inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and Kawasaki disease.

    Gene expression databases

    BgeeiP80511.
    CleanExiHS_S100A12.
    GenevestigatoriP80511.

    Organism-specific databases

    HPAiCAB025872.
    HPA002881.

    Interactioni

    Subunit structurei

    Homodimer. Homooligomer (tetramer or hexamer) in the presence of calcium, zinc and copper ions. Interacts with AGER and both calcium and zinc are essential for the interaction. Interacts with CACYBP in a calcium-dependent manner.2 Publications

    Protein-protein interaction databases

    BioGridi112191. 1 interaction.
    IntActiP80511. 1 interaction.
    MINTiMINT-239108.
    STRINGi9606.ENSP00000357726.

    Structurei

    Secondary structure

    1
    92
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 1917
    Beta strandi21 – 244
    Beta strandi27 – 293
    Helixi30 – 4011
    Helixi42 – 476
    Helixi51 – 588
    Beta strandi61 – 644
    Beta strandi67 – 704
    Helixi71 – 8919

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1E8AX-ray1.95A/B2-92[»]
    1GQMX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L2-92[»]
    1ODBX-ray2.19A/B/C/D/E/F2-92[»]
    2M9GNMR-A/B1-92[»]
    2WC8X-ray1.88A/B/C/D2-92[»]
    2WCBX-ray1.73A/B2-92[»]
    2WCEX-ray1.77A/B2-92[»]
    2WCFX-ray2.78A/B/C/D/E/F2-92[»]
    ProteinModelPortaliP80511.
    SMRiP80511. Positions 2-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP80511.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 4836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini49 – 8436EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni38 – 5316Hinge domainAdd
    BLAST

    Domaini

    The hinge domain contributes significantly to its chemotactic properties.1 Publication

    Sequence similaritiesi

    Belongs to the S-101 family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG87949.
    HOGENOMiHOG000246968.
    HOVERGENiHBG001479.
    InParanoidiP80511.
    OMAiHYHTHKE.
    OrthoDBiEOG7M3J2R.
    PhylomeDBiP80511.
    TreeFamiTF332727.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view]
    PfamiPF01023. S_100. 1 hit.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80511-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKLEEHLEG IVNIFHQYSV RKGHFDTLSK GELKQLLTKE LANTIKNIKD   50
    KAVIDEIFQG LDANQDEQVD FQEFISLVAI ALKAAHYHTH KE 92
    Length:92
    Mass (Da):10,575
    Last modified:January 23, 2007 - v2
    Checksum:i52AF75A31BDC222A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71H → V AA sequence (PubMed:1860454)Curated
    Sequence conflicti12 – 132VN → YS AA sequence (PubMed:1860454)Curated
    Sequence conflicti16 – 161H → F AA sequence (PubMed:1860454)Curated

    Mass spectrometryi

    Molecular mass is 10444 Da from positions 2 - 92. Determined by ESI. 1 Publication
    Molecular mass is 1688.9 Da from positions 78 - 92. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49549 mRNA. Translation: BAA08497.1.
    D83657 Genomic DNA. Translation: BAA12030.1.
    D83664 mRNA. Translation: BAA12036.1.
    X97859 mRNA. Translation: CAA66453.1.
    X98289, X98290 Genomic DNA. Translation: CAB94792.1.
    AL591704 Genomic DNA. Translation: CAI19495.1.
    BC070294 mRNA. Translation: AAH70294.1.
    CCDSiCCDS1037.1.
    PIRiA61522.
    JC4712.
    RefSeqiNP_005612.1. NM_005621.1.
    UniGeneiHs.19413.

    Genome annotation databases

    EnsembliENST00000368737; ENSP00000357726; ENSG00000163221.
    GeneIDi6283.
    KEGGihsa:6283.
    UCSCiuc001fbr.1. human.

    Polymorphism databases

    DMDMi2507565.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49549 mRNA. Translation: BAA08497.1 .
    D83657 Genomic DNA. Translation: BAA12030.1 .
    D83664 mRNA. Translation: BAA12036.1 .
    X97859 mRNA. Translation: CAA66453.1 .
    X98289 , X98290 Genomic DNA. Translation: CAB94792.1 .
    AL591704 Genomic DNA. Translation: CAI19495.1 .
    BC070294 mRNA. Translation: AAH70294.1 .
    CCDSi CCDS1037.1.
    PIRi A61522.
    JC4712.
    RefSeqi NP_005612.1. NM_005621.1.
    UniGenei Hs.19413.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1E8A X-ray 1.95 A/B 2-92 [» ]
    1GQM X-ray 2.70 A/B/C/D/E/F/G/H/I/J/K/L 2-92 [» ]
    1ODB X-ray 2.19 A/B/C/D/E/F 2-92 [» ]
    2M9G NMR - A/B 1-92 [» ]
    2WC8 X-ray 1.88 A/B/C/D 2-92 [» ]
    2WCB X-ray 1.73 A/B 2-92 [» ]
    2WCE X-ray 1.77 A/B 2-92 [» ]
    2WCF X-ray 2.78 A/B/C/D/E/F 2-92 [» ]
    ProteinModelPortali P80511.
    SMRi P80511. Positions 2-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112191. 1 interaction.
    IntActi P80511. 1 interaction.
    MINTi MINT-239108.
    STRINGi 9606.ENSP00000357726.

    Chemistry

    DrugBanki DB01025. Amlexanox.

    PTM databases

    PhosphoSitei P80511.

    Polymorphism databases

    DMDMi 2507565.

    Proteomic databases

    PaxDbi P80511.
    PRIDEi P80511.

    Protocols and materials databases

    DNASUi 6283.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368737 ; ENSP00000357726 ; ENSG00000163221 .
    GeneIDi 6283.
    KEGGi hsa:6283.
    UCSCi uc001fbr.1. human.

    Organism-specific databases

    CTDi 6283.
    GeneCardsi GC01M153346.
    HGNCi HGNC:10489. S100A12.
    HPAi CAB025872.
    HPA002881.
    MIMi 603112. gene.
    neXtProti NX_P80511.
    PharmGKBi PA34901.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87949.
    HOGENOMi HOG000246968.
    HOVERGENi HBG001479.
    InParanoidi P80511.
    OMAi HYHTHKE.
    OrthoDBi EOG7M3J2R.
    PhylomeDBi P80511.
    TreeFami TF332727.

    Enzyme and pathway databases

    Reactomei REACT_118563. RIP-mediated NFkB activation via ZBP1.
    REACT_21281. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_24969. TRAF6 mediated NF-kB activation.
    REACT_25195. Advanced glycosylation endproduct receptor signaling.

    Miscellaneous databases

    EvolutionaryTracei P80511.
    GeneWikii S100A12.
    GenomeRNAii 6283.
    NextBioi 24389.
    PROi P80511.
    SOURCEi Search...

    Gene expression databases

    Bgeei P80511.
    CleanExi HS_S100A12.
    Genevestigatori P80511.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view ]
    Pfami PF01023. S_100. 1 hit.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human CAAF1 gene -- molecular cloning, gene structure, and chromosome mapping."
      Yamamura T., Hitomi J., Nagasaki K., Suzuki M., Takahashi E., Saito S., Tsukada T., Yamaguchi K.
      Biochem. Biophys. Res. Commun. 221:356-360(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21."
      Wicki R., Marenholz I., Mischke D., Schaefer B.W., Heizmann C.W.
      Cell Calcium 20:459-464(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    5. "Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin."
      Marti T., Erttmann K.D., Gallin M.Y.
      Biochem. Biophys. Res. Commun. 221:454-458(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-92.
    6. "Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry."
      Ilg E.C., Troxler H., Buergisser D.M., Kuster T., Markert M., Guignard F., Hunziker P., Birchler N., Heizmann C.W.
      Biochem. Biophys. Res. Commun. 225:146-150(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-92.
      Tissue: Neutrophil.
    7. "Identification and characterization of a novel human neutrophil protein related to the S100 family."
      Guignard F., Mauel J., Markert M.
      Biochem. J. 309:395-401(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-21.
    8. "Identification, isolation, and partial characterization of a 7.5-kDa surfactant-associated protein."
      Singh G., Katyal S.L., Brown W.E., Kennedy A.L., Wong-Chong M.-L., Gottron S.A.
      Exp. Lung Res. 17:559-567(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-16.
    9. "Calcitermin, a novel antimicrobial peptide isolated from human airway secretions."
      Cole A.M., Kim Y.-H., Tahk S., Hong T., Weis P., Waring A.J., Ganz T.
      FEBS Lett. 504:5-10(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 78-92, FUNCTION AS AN ANTIMICROBIAL PROTEIN, MASS SPECTROMETRY.
      Tissue: Nasal mucus.
    10. "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family."
      Filipek A., Jastrzebska B., Nowotny M., Kuznicki J.
      J. Biol. Chem. 277:28848-28852(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CACYBP.
    11. "Multiple structural states of S100A12: A key to its functional diversity."
      Moroz O.V., Dodson G.G., Wilson K.S., Lukanidin E., Bronstein I.B.
      Microsc. Res. Tech. 60:581-592(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    12. Cited for: FUNCTION.
    13. "Mast cell and monocyte recruitment by S100A12 and its hinge domain."
      Yan W.X., Armishaw C., Goyette J., Yang Z., Cai H., Alewood P., Geczy C.L.
      J. Biol. Chem. 283:13035-13043(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DOMAIN HINGE.
    14. "Human S100A12: a novel key player in inflammation?"
      Pietzsch J., Hoppmann S.
      Amino Acids 36:381-389(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    15. Cited for: REVIEW.
    16. Cited for: FUNCTION, SUBUNIT, INTERACTION WITH AGER.
    17. "S100 Calgranulins in inflammatory arthritis."
      Perera C., McNeil H.P., Geczy C.L.
      Immunol. Cell Biol. 88:41-49(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    18. "Inflammation-associated S100 proteins: new mechanisms that regulate function."
      Goyette J., Geczy C.L.
      Amino Acids 41:821-842(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    19. "The role of S100A12 as a systemic marker of inflammation."
      Meijer B., Gearry R.B., Day A.S.
      Int. J. Inflamm. 2012:907078-907078(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW, SUBCELLULAR LOCATION.
    20. Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).
    21. "Structure of the human S100A12-copper complex: implications for host-parasite defence."
      Moroz O.V., Antson A.A., Grist S.J., Maitland N.J., Dodson G.G., Wilson K.S., Lukanidin E., Bronstein I.B.
      Acta Crystallogr. D 59:859-867(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS), COPPER-BINDING.
    22. "The crystal structures of human S100A12 in apo form and in complex with zinc: new insights into S100A12 oligomerisation."
      Moroz O.V., Blagova E.V., Wilkinson A.J., Wilson K.S., Bronstein I.B.
      J. Mol. Biol. 391:536-551(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 2-92, ZINC-BINDING.

    Entry informationi

    Entry nameiS10AC_HUMAN
    AccessioniPrimary (citable) accession number: P80511
    Secondary accession number(s): P83219, Q5SY66, Q7M4R1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 145 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3