Reviewed, UniProtKB/Swiss-Prot P80509 (HC3L_THIFE)

Names and origin

Protein names

Recommended name:
    Cytochrome c3 hydrogenase large chain
      Short name=Hydrogenase
    EC=1.12.2.1

Gene names

Name:

hoxG

Organism

Thiobacillus ferrooxidans (Acidithiobacillus ferrooxidans)

Taxonomic identifier

920 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Acidithiobacillales › Acidithiobacillaceae › Acidithiobacillus

Protein attributes

Sequence length	122 AA.
Sequence status	Fragments.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3.
Cofactor	Iron.
Caution	The order of the peptides shown is uncertain. It is also unknown if gaps exist between the peptides.

Ontologies

Keywords
Ligand	Iron
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytochrome-c3 hydrogenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›122	›122	Cytochrome c3 hydrogenase large chain		PRO_0000083913
Experimental info
	Non-adjacent residues	20 – 21	2
	Non-adjacent residues	29 – 30	2
	Non-adjacent residues	35 – 36	2
	Non-adjacent residues	42 – 43	2
	Non-adjacent residues	59 – 60	2
	Non-adjacent residues	72 – 73	2
	Non-adjacent residues	78 – 79	2
	Non-adjacent residues	87 – 88	2
	Non-adjacent residues	98 – 99	2
	Non-adjacent residues	107 – 108	2
	Non-terminal residue	122	1

Sequences

	Sequence		Length	Mass (Da)
	P80509-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: EB4FAF365348DA0B	FASTA	122	13,152
	10 20 30 40 50 60 XTAVQTLDIS PVGRVEGDLD SXSILEYFRN AILARFGGGL GKYAPFTGTN YEIGVTISGD 70 80 90 100 110 120 KDPQAGLVVT PRESTTXGLN EPFYIKPYVS XGYIPHEDGA LAHXIEVDGV VVEAYTQAEL FR

References

[1]	"Purification and characterization of the hydrogenase from Thiobacillus ferrooxidans." Fischer J., Quentmeier A., Kostka S., Kraft R., Friedrich C.G. Arch. Microbiol. 165:289-296(1996) [PubMed: 8661919] [Abstract] Cited for: PROTEIN SEQUENCE. Strain: ATCC 19859 / NCIB 9490.

Cross-references

3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.12.2.1. 49.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

HC3L_THIFE

Accession

Primary (citable) accession number: P80509

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 20, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)