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P80498 - COX2_SOLTU

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Cytochrome c oxidase subunit 2



Solanum tuberosum (Potato)
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli


Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.


Cu cationNote: Binds a copper A center.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni


Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi


Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Synonyms:COII, COXII
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
ProteomesiUP000011115: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›26›26Cytochrome c oxidase subunit 2PRO_0000183692Add

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini


Family and domain databases

Gene3Di1.10.287.90. 1 hit.
InterProiIPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF81464. SSF81464. 1 hit.


Sequence statusi: Fragment.

P80498-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20 
Mass (Da):2,875
Last modified:February 1, 1996 - v1

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei26 – 261


3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1 hit.
InterProi IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF81464. SSF81464. 1 hit.
ProtoNeti Search...


  1. "New insights into the composition, molecular mass and stoichiometry of the protein complexes of plant mitochondria."
    Jansch L., Kruft V., Schmitz U.K., Braun H.P.
    Plant J. 9:357-368(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Tuber.

Entry informationi

Entry nameiCOX2_SOLTU
AccessioniPrimary (citable) accession number: P80498
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program


Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome


  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.