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P80480 (SDHB_RECAM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit

EC=1.3.5.1
Alternative name(s):
Iron-sulfur subunit of complex II
Short name=Ip
Gene names
Name:SDH2
Synonyms:SDHB
Encoded onMitochondrion
OrganismReclinomonas americana
Taxonomic identifier48483 [NCBI]
Taxonomic lineageEukaryotaJakobidaHistionidaeReclinomonas

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239Succinate dehydrogenase [ubiquinone] iron-sulfur subunit
PRO_0000158697

Regions

Domain11 – 100902Fe-2S ferredoxin-type
Domain141 – 171314Fe-4S ferredoxin-type

Sites

Metal binding611Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding661Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding691Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding811Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1511Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1541Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1571Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1611Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2081Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2141Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2181Iron-sulfur 2 (4Fe-4S) By similarity
Binding site1661Ubiquinone; shared with DHSD By similarity

Sequences

Sequence LengthMass (Da)Tools
P80480 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 781C6FF0ED55375B

FASTA23927,828
        10         20         30         40         50         60 
MNTKKEKIML FKVYRWNPDK KEKPHISTYS VDLNSCGPMV LDALIKIKNE QDSTLTFRRS 

        70         80         90        100        110        120 
CREGVCGSCA MNIDGTNTLA CIKSIDTNKK EMKIYPLPHM HIIKDLVPDL SNFYAQYKSI 

       130        140        150        160        170        180 
EPWMKTTEKK LDKEFYQSRN DREKLDGLYE CVLCACCSTS CPSYWWNSDK YLGPAVLLQA 

       190        200        210        220        230 
YRWIVDSRDQ GTRERLQYLE DPFKLYRCHT ILNCTKTCPK HLNPAQAIAK IKQNITLLT 

« Hide

References

[1]"Genes encoding the same three subunits of respiratory complex II are present in the mitochondrial DNA of two phylogenetically distant eukaryotes."
Burger G., Lang B.F., Reith M., Gray M.W.
Proc. Natl. Acad. Sci. U.S.A. 93:2328-2332(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 50394.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF007261 Genomic DNA. Translation: AAD11913.1.
PIRS78180.
RefSeqNP_044798.1. NC_001823.1.

3D structure databases

ProteinModelPortalP80480.
SMRP80480. Positions 7-233.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

ProMEXP80480.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID801067.

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHB_RECAM
AccessionPrimary (citable) accession number: P80480
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways