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P80480

- SDHB_RECAM

UniProt

P80480 - SDHB_RECAM

Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit

Gene

SDH2

Organism
Reclinomonas americana
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity
    Binds 1 3Fe-4S cluster.By similarity
    Binds 1 4Fe-4S cluster.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi61 – 611Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi66 – 661Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi69 – 691Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi81 – 811Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi151 – 1511Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi154 – 1541Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi157 – 1571Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi161 – 1611Iron-sulfur 3 (3Fe-4S)By similarity
    Binding sitei166 – 1661Ubiquinone; shared with DHSDBy similarity
    Metal bindingi208 – 2081Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi214 – 2141Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi218 – 2181Iron-sulfur 2 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    4. electron carrier activity Source: InterPro
    5. metal ion binding Source: UniProtKB-KW
    6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit (EC:1.3.5.1)
    Alternative name(s):
    Iron-sulfur subunit of complex II
    Short name:
    Ip
    Gene namesi
    Name:SDH2
    Synonyms:SDHB
    Encoded oniMitochondrion
    OrganismiReclinomonas americana
    Taxonomic identifieri48483 [NCBI]
    Taxonomic lineageiEukaryotaJakobidaHistionidaeReclinomonas

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239Succinate dehydrogenase [ubiquinone] iron-sulfur subunitPRO_0000158697Add
    BLAST

    Proteomic databases

    ProMEXiP80480.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP80480.
    SMRiP80480. Positions 7-233.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 100902Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini141 – 171314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view]
    PfamiPF13085. Fer2_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR00384. dhsB. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P80480-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTKKEKIML FKVYRWNPDK KEKPHISTYS VDLNSCGPMV LDALIKIKNE    50
    QDSTLTFRRS CREGVCGSCA MNIDGTNTLA CIKSIDTNKK EMKIYPLPHM 100
    HIIKDLVPDL SNFYAQYKSI EPWMKTTEKK LDKEFYQSRN DREKLDGLYE 150
    CVLCACCSTS CPSYWWNSDK YLGPAVLLQA YRWIVDSRDQ GTRERLQYLE 200
    DPFKLYRCHT ILNCTKTCPK HLNPAQAIAK IKQNITLLT 239
    Length:239
    Mass (Da):27,828
    Last modified:October 1, 1996 - v1
    Checksum:i781C6FF0ED55375B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007261 Genomic DNA. Translation: AAD11913.1.
    PIRiS78180.
    RefSeqiNP_044798.1. NC_001823.1.

    Genome annotation databases

    GeneIDi801067.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007261 Genomic DNA. Translation: AAD11913.1 .
    PIRi S78180.
    RefSeqi NP_044798.1. NC_001823.1.

    3D structure databases

    ProteinModelPortali P80480.
    SMRi P80480. Positions 7-233.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    ProMEXi P80480.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 801067.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view ]
    Pfami PF13085. Fer2_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR00384. dhsB. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes encoding the same three subunits of respiratory complex II are present in the mitochondrial DNA of two phylogenetically distant eukaryotes."
      Burger G., Lang B.F., Reith M., Gray M.W.
      Proc. Natl. Acad. Sci. U.S.A. 93:2328-2332(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 50394.

    Entry informationi

    Entry nameiSDHB_RECAM
    AccessioniPrimary (citable) accession number: P80480
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3