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P80480

- SDHB_RECAM

UniProt

P80480 - SDHB_RECAM

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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit

Gene
SDH2, SDHB
Organism
Reclinomonas americana
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Binds 1 2Fe-2S cluster By similarity.
Binds 1 3Fe-4S cluster By similarity.
Binds 1 4Fe-4S cluster By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi66 – 661Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi69 – 691Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi81 – 811Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi151 – 1511Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi154 – 1541Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi157 – 1571Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi161 – 1611Iron-sulfur 3 (3Fe-4S) By similarity
Binding sitei166 – 1661Ubiquinone; shared with DHSD By similarity
Metal bindingi208 – 2081Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi214 – 2141Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi218 – 2181Iron-sulfur 2 (4Fe-4S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:SDH2
Synonyms:SDHB
Encoded oniMitochondrion
OrganismiReclinomonas americana
Taxonomic identifieri48483 [NCBI]
Taxonomic lineageiEukaryotaJakobidaHistionidaeReclinomonas

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Succinate dehydrogenase [ubiquinone] iron-sulfur subunitPRO_0000158697Add
BLAST

Proteomic databases

ProMEXiP80480.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.

Structurei

3D structure databases

ProteinModelPortaliP80480.
SMRiP80480. Positions 7-233.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 100902Fe-2S ferredoxin-typeAdd
BLAST
Domaini141 – 171314Fe-4S ferredoxin-typeAdd
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80480-1 [UniParc]FASTAAdd to Basket

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MNTKKEKIML FKVYRWNPDK KEKPHISTYS VDLNSCGPMV LDALIKIKNE    50
QDSTLTFRRS CREGVCGSCA MNIDGTNTLA CIKSIDTNKK EMKIYPLPHM 100
HIIKDLVPDL SNFYAQYKSI EPWMKTTEKK LDKEFYQSRN DREKLDGLYE 150
CVLCACCSTS CPSYWWNSDK YLGPAVLLQA YRWIVDSRDQ GTRERLQYLE 200
DPFKLYRCHT ILNCTKTCPK HLNPAQAIAK IKQNITLLT 239
Length:239
Mass (Da):27,828
Last modified:October 1, 1996 - v1
Checksum:i781C6FF0ED55375B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007261 Genomic DNA. Translation: AAD11913.1.
PIRiS78180.
RefSeqiNP_044798.1. NC_001823.1.

Genome annotation databases

GeneIDi801067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007261 Genomic DNA. Translation: AAD11913.1 .
PIRi S78180.
RefSeqi NP_044798.1. NC_001823.1.

3D structure databases

ProteinModelPortali P80480.
SMRi P80480. Positions 7-233.
ModBasei Search...
MobiDBi Search...

Proteomic databases

ProMEXi P80480.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 801067.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genes encoding the same three subunits of respiratory complex II are present in the mitochondrial DNA of two phylogenetically distant eukaryotes."
    Burger G., Lang B.F., Reith M., Gray M.W.
    Proc. Natl. Acad. Sci. U.S.A. 93:2328-2332(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 50394.

Entry informationi

Entry nameiSDHB_RECAM
AccessioniPrimary (citable) accession number: P80480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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