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P80477 (SDHB_PORPU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit

EC=1.3.5.1
Alternative name(s):
Iron-sulfur subunit of complex II
Short name=Ip
Gene names
Name:SDH2
Synonyms:SDHB
Encoded onMitochondrion
OrganismPorphyra purpurea (Red seaweed)
Taxonomic identifier2787 [NCBI]
Taxonomic lineageEukaryotaRhodophytaBangiophyceaeBangialesBangiaceaePorphyra

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239Succinate dehydrogenase [ubiquinone] iron-sulfur subunit
PRO_0000158696

Regions

Domain24 – 99762Fe-2S ferredoxin-type
Domain142 – 172314Fe-4S ferredoxin-type

Sites

Metal binding631Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding681Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding711Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding831Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1521Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1551Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1581Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1621Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2091Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2151Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2191Iron-sulfur 2 (4Fe-4S) By similarity
Binding site1671Ubiquinone; shared with DHSD By similarity

Sequences

Sequence LengthMass (Da)Tools
P80477 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 5209A3754CAC3E20

FASTA23927,301
        10         20         30         40         50         60 
MRPRNNNLNL KFIRIYRWTP SNQAEAKFSV HPIHTSNCGP MILDALIKIK DEQDSSLAFR 

        70         80         90        100        110        120 
RSCREGICGS CSMNIDGINT LACLKPIKTN ANIITIYPLP HMYIIKDLVP DLSNFFSQYK 

       130        140        150        160        170        180 
YIKPWLINNV PKKSEYLQSE KDRSELNGIY ECILCACCSA SCPSYWWNHD KYLGPAILLQ 

       190        200        210        220        230 
AYRWLADSRD TNAKERLKLL GGKSKLFKCH TIMNCSRTCP KSLNPGKAIA SIKHSINYS 

« Hide

References

[1]"Genes encoding the same three subunits of respiratory complex II are present in the mitochondrial DNA of two phylogenetically distant eukaryotes."
Burger G., Lang B.F., Reith M., Gray M.W.
Proc. Natl. Acad. Sci. U.S.A. 93:2328-2332(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

3D structure databases

ProteinModelPortalP80477.
SMRP80477. Positions 10-233.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHB_PORPU
AccessionPrimary (citable) accession number: P80477
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways