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Protein

Alcohol dehydrogenase class-3

Gene
N/A
Organism
Saara hardwickii (Indian spiny-tailed lizard) (Uromastyx hardwickii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Zinc 1; catalytic1
Metal bindingi66Zinc 1; catalytic1
Metal bindingi96Zinc 21
Metal bindingi99Zinc 21
Metal bindingi102Zinc 21
Metal bindingi110Zinc 21
Sitei114Important for FDH activity and activation by fatty acidsBy similarity1
Metal bindingi173Zinc 1; catalytic1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-3 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
OrganismiSaara hardwickii (Indian spiny-tailed lizard) (Uromastyx hardwickii)
Taxonomic identifieri40250 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaAcrodontaAgamidaeUromastycinaeSaara

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607671 – 373Alcohol dehydrogenase class-3Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP80467

PTM databases

iPTMnetiP80467

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP80467
SMRiP80467
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000195

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P80467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASGVIKCKAA VAWEAGKPLS IEEIEVAPPK AHEVRVKIIA TAVCHTDAYT
60 70 80 90 100
LSGADPEGSF PVILGHEGAG IVESVGEGVT KFKPGDTVIP LYIPQCGECK
110 120 130 140 150
FCLNPKTNLC QKIRVTQGKG VMPDGTSRFT CKGKQVLHFM GTSTFSEYTV
160 170 180 190 200
VADISLTKIN ASAPLDKVCL LGCGVSTGYG AALNTAKVEP GSTCAVFGLG
210 220 230 240 250
GVGLAVIMGC KVAGASRIIG IDLNKDKFAK AKEFGATECI SPADFKKPIQ
260 270 280 290 300
EVLIEMTDGG VDYSFECIGN VGVMRAALEA CHKGWGVSVI VGVAAAGQEI
310 320 330 340 350
ATRPFQLVTG RTWKGTAFGG WKSVESVPKL VDEYMSKKMK VDEFVTHTLP
360 370
FEQINEAFEL MHAGKSIRSV LKF
Length:373
Mass (Da):39,430
Last modified:February 1, 1996 - v1
Checksum:i2BB3B44A0A9FCF06
GO

Sequence databases

PIRiS68061

Similar proteinsi

Entry informationi

Entry nameiADHX_SAAHA
AccessioniPrimary (citable) accession number: P80467
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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