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P80458

- MDH_RHOPA

UniProt

P80458 - MDH_RHOPA

Protein

Malate dehydrogenase

Gene

mdh

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (16 Feb 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADBy similarity
    Binding sitei83 – 831SubstrateBy similarity
    Binding sitei89 – 891SubstrateBy similarity
    Binding sitei96 – 961NADBy similarity
    Binding sitei121 – 1211SubstrateBy similarity
    Binding sitei152 – 1521SubstrateBy similarity
    Active sitei176 – 1761Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADBy similarity
    Nucleotide bindingi119 – 1213NADBy similarity

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase (EC:1.1.1.37)
    Gene namesi
    Name:mdh
    Ordered Locus Names:RPA0192
    OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
    Taxonomic identifieri258594 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000001426: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Malate dehydrogenasePRO_0000113465Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi258594.RPA0192.

    Structurei

    3D structure databases

    ProteinModelPortaliP80458.
    SMRiP80458. Positions 1-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.Curated

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiYAPSAFV.
    OrthoDBiEOG6091FG.
    PhylomeDBiP80458.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P80458-1 [UniParc]FASTAAdd to Basket

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    MARDKIALIG SGQIGGTLAH LVGLKELGDV VLFDIAEGVP QGKALDIAES    50
    SPVDGFDSKL TGANSYEAIE GARVVIVTAG VPRKPGMSRD DLLSINLKVM 100
    EQVGAGIKKY APDAFVICIT NPLDAMVWAL QKASGLPAKK VVGMAGVLDS 150
    ARFRYFLADE FNVSVEDVTA FVLGGHGDTM VPLVKYSTVA GIPLPDLVKM 200
    GWTSQARLDE IVDRTRNGGA EIVNLLKTGS AFYAPASSAI AMAESYLKDK 250
    KRVVPVAAHL NGEYGVKDMY VGVPVVIGDK GVERIVEIEL AGKDKEAFDR 300
    SVAAVQGLVE ACKKIAPDLL GR 322
    Length:322
    Mass (Da):33,996
    Last modified:February 16, 2004 - v2
    Checksum:i8F41556B89B2D187
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131Q → E AA sequence 1 PublicationCurated
    Sequence conflicti21 – 222LV → MI AA sequence 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX572593 Genomic DNA. Translation: CAE25636.1.
    RefSeqiNP_945545.1. NC_005296.1.
    WP_011155760.1. NC_005296.1.

    Genome annotation databases

    EnsemblBacteriaiCAE25636; CAE25636; RPA0192.
    GeneIDi2691678.
    KEGGirpa:RPA0192.
    PATRICi23284495. VBIRhoPal84835_0199.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX572593 Genomic DNA. Translation: CAE25636.1 .
    RefSeqi NP_945545.1. NC_005296.1.
    WP_011155760.1. NC_005296.1.

    3D structure databases

    ProteinModelPortali P80458.
    SMRi P80458. Positions 1-313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 258594.RPA0192.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE25636 ; CAE25636 ; RPA0192 .
    GeneIDi 2691678.
    KEGGi rpa:RPA0192.
    PATRICi 23284495. VBIRhoPal84835_0199.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi YAPSAFV.
    OrthoDBi EOG6091FG.
    PhylomeDBi P80458.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-98 / CGA009.
    2. Naterstad K., Synstad B., Sirevag R.
      Submitted (SEP-1996) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 5-25.

    Entry informationi

    Entry nameiMDH_RHOPA
    AccessioniPrimary (citable) accession number: P80458
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 16, 2004
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3