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Protein

40S ribosomal protein S12

Gene

RpS12

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S12
Gene namesi
Name:RpS12
Synonyms:RpS12E
ORF Names:CG11271
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0260441. RpS12.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001223301 – 13940S ribosomal protein S12Add BLAST139

Proteomic databases

PaxDbiP80455.
PRIDEiP80455.

Expressioni

Gene expression databases

BgeeiFBgn0260441.
GenevisibleiP80455. DM.

Interactioni

Protein-protein interaction databases

BioGridi64826. 24 interactors.
IntActiP80455. 4 interactors.
MINTiMINT-1551339.
STRINGi7227.FBpp0075612.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AM1-139[»]
ProteinModelPortaliP80455.
SMRiP80455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3406. Eukaryota.
COG1358. LUCA.
InParanoidiP80455.
KOiK02951.
OMAiGLRECAK.
OrthoDBiEOG091G0UB5.
PhylomeDBiP80455.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiView protein in InterPro
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR000530. Ribosomal_S12e.
PANTHERiPTHR11843. PTHR11843. 1 hit.
PfamiView protein in Pfam
PF01248. Ribosomal_L7Ae. 1 hit.
PRINTSiPR00972. RIBSOMALS12E.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiView protein in PROSITE
PS01189. RIBOSOMAL_S12E. 1 hit.

Sequencei

Sequence statusi: Complete.

P80455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVDVDVPS AAPVLDGAMD INTALQEVLK KSLIADGLVH GIHQACKALD
60 70 80 90 100
KRQAVLCILA ESFDEPNYKK LVTALCNEHQ IPLIRVDSHK KLGEWSGLCK
110 120 130
IDKEGKPRKV CGCSVVVIKD FGEETPALDV VKDHLRQNS
Length:139
Mass (Da):15,169
Last modified:December 8, 2000 - v2
Checksum:i4810D50ADC87C253
GO

Sequence cautioni

The sequence CAA61806 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89659 mRNA. Translation: CAA61806.1. Different initiation.
AE014296 Genomic DNA. Translation: AAN11845.1.
AY058531 mRNA. Translation: AAL13760.1.
PIRiS58022.
RefSeqiNP_729866.1. NM_168534.4.
UniGeneiDm.3295.

Genome annotation databases

EnsemblMetazoaiFBtr0075878; FBpp0075612; FBgn0260441.
GeneIDi39480.
KEGGidme:Dmel_CG11271.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRS12_DROME
AccessioniPrimary (citable) accession number: P80455
Secondary accession number(s): Q0E8F1, Q9VU40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 8, 2000
Last modified: July 5, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families