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Protein

40S ribosomal protein S12

Gene

RpS12

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-DME-72649 Translation initiation complex formation
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-DME-72702 Ribosomal scanning and start codon recognition
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S12
Gene namesi
Name:RpS12
Synonyms:RpS12E
ORF Names:CG11271
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0260441 RpS12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001223301 – 13940S ribosomal protein S12Add BLAST139

Proteomic databases

PaxDbiP80455
PRIDEiP80455

Expressioni

Gene expression databases

BgeeiFBgn0260441
GenevisibleiP80455 DM

Interactioni

Protein-protein interaction databases

BioGridi64826, 25 interactors
IntActiP80455, 27 interactors
STRINGi7227.FBpp0075612

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AM1-139[»]
ProteinModelPortaliP80455
SMRiP80455
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3406 Eukaryota
COG1358 LUCA
GeneTreeiENSGT00390000018318
InParanoidiP80455
KOiK02951
OMAiGLRECAK
OrthoDBiEOG091G0UB5
PhylomeDBiP80455

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR000530 Ribosomal_S12e
PANTHERiPTHR11843 PTHR11843, 1 hit
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
PRINTSiPR00972 RIBSOMALS12E
SUPFAMiSSF55315 SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS01189 RIBOSOMAL_S12E, 1 hit

Sequencei

Sequence statusi: Complete.

P80455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVDVDVPS AAPVLDGAMD INTALQEVLK KSLIADGLVH GIHQACKALD
60 70 80 90 100
KRQAVLCILA ESFDEPNYKK LVTALCNEHQ IPLIRVDSHK KLGEWSGLCK
110 120 130
IDKEGKPRKV CGCSVVVIKD FGEETPALDV VKDHLRQNS
Length:139
Mass (Da):15,169
Last modified:December 8, 2000 - v2
Checksum:i4810D50ADC87C253
GO

Sequence cautioni

The sequence CAA61806 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89659 mRNA Translation: CAA61806.1 Different initiation.
AE014296 Genomic DNA Translation: AAN11845.1
AY058531 mRNA Translation: AAL13760.1
PIRiS58022
RefSeqiNP_729866.1, NM_168534.4
UniGeneiDm.3295

Genome annotation databases

EnsemblMetazoaiFBtr0075878; FBpp0075612; FBgn0260441
GeneIDi39480
KEGGidme:Dmel_CG11271

Similar proteinsi

Entry informationi

Entry nameiRS12_DROME
AccessioniPrimary (citable) accession number: P80455
Secondary accession number(s): Q0E8F1, Q9VU40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 8, 2000
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health