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Protein

40S ribosomal protein S12

Gene

RpS12

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-6791226. Major pathway of rRNA processing in the nucleolus.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S12
Gene namesi
Name:RpS12
Synonyms:RpS12E
ORF Names:CG11271
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0260441. RpS12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13913940S ribosomal protein S12PRO_0000122330Add
BLAST

Proteomic databases

PaxDbiP80455.
PRIDEiP80455.

Expressioni

Gene expression databases

BgeeiFBgn0260441.
GenevisibleiP80455. DM.

Interactioni

Protein-protein interaction databases

BioGridi64826. 24 interactions.
IntActiP80455. 4 interactions.
MINTiMINT-1551339.
STRINGi7227.FBpp0075612.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AM1-139[»]
ProteinModelPortaliP80455.
SMRiP80455. Positions 17-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S12e family.Curated

Phylogenomic databases

eggNOGiKOG3406. Eukaryota.
COG1358. LUCA.
GeneTreeiENSGT00390000018318.
InParanoidiP80455.
KOiK02951.
OMAiNCDEPTY.
OrthoDBiEOG091G0UB5.
PhylomeDBiP80455.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR000530. Ribosomal_S12e.
[Graphical view]
PANTHERiPTHR11843. PTHR11843. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00972. RIBSOMALS12E.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01189. RIBOSOMAL_S12E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVDVDVPS AAPVLDGAMD INTALQEVLK KSLIADGLVH GIHQACKALD
60 70 80 90 100
KRQAVLCILA ESFDEPNYKK LVTALCNEHQ IPLIRVDSHK KLGEWSGLCK
110 120 130
IDKEGKPRKV CGCSVVVIKD FGEETPALDV VKDHLRQNS
Length:139
Mass (Da):15,169
Last modified:December 8, 2000 - v2
Checksum:i4810D50ADC87C253
GO

Sequence cautioni

The sequence CAA61806 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89659 mRNA. Translation: CAA61806.1. Different initiation.
AE014296 Genomic DNA. Translation: AAN11845.1.
AY058531 mRNA. Translation: AAL13760.1.
PIRiS58022.
RefSeqiNP_729866.1. NM_168534.4.
UniGeneiDm.3295.

Genome annotation databases

EnsemblMetazoaiFBtr0075878; FBpp0075612; FBgn0260441.
GeneIDi39480.
KEGGidme:Dmel_CG11271.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89659 mRNA. Translation: CAA61806.1. Different initiation.
AE014296 Genomic DNA. Translation: AAN11845.1.
AY058531 mRNA. Translation: AAL13760.1.
PIRiS58022.
RefSeqiNP_729866.1. NM_168534.4.
UniGeneiDm.3295.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AM1-139[»]
ProteinModelPortaliP80455.
SMRiP80455. Positions 17-136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64826. 24 interactions.
IntActiP80455. 4 interactions.
MINTiMINT-1551339.
STRINGi7227.FBpp0075612.

Proteomic databases

PaxDbiP80455.
PRIDEiP80455.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0075878; FBpp0075612; FBgn0260441.
GeneIDi39480.
KEGGidme:Dmel_CG11271.

Organism-specific databases

CTDi6206.
FlyBaseiFBgn0260441. RpS12.

Phylogenomic databases

eggNOGiKOG3406. Eukaryota.
COG1358. LUCA.
GeneTreeiENSGT00390000018318.
InParanoidiP80455.
KOiK02951.
OMAiNCDEPTY.
OrthoDBiEOG091G0UB5.
PhylomeDBiP80455.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-6791226. Major pathway of rRNA processing in the nucleolus.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpS12. fly.
GenomeRNAii39480.
PROiP80455.

Gene expression databases

BgeeiFBgn0260441.
GenevisibleiP80455. DM.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR000530. Ribosomal_S12e.
[Graphical view]
PANTHERiPTHR11843. PTHR11843. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00972. RIBSOMALS12E.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01189. RIBOSOMAL_S12E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS12_DROME
AccessioniPrimary (citable) accession number: P80455
Secondary accession number(s): Q0E8F1, Q9VU40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 8, 2000
Last modified: September 7, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.