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P80440

- COX1_ALLMA

UniProt

P80440 - COX1_ALLMA

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Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Allomyces macrogynus
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi67 – 671Iron (heme A axial ligand)Curated
Metal bindingi246 – 2461Copper BCurated
Metal bindingi250 – 2501Copper BCurated
Metal bindingi295 – 2951Copper BCurated
Metal bindingi296 – 2961Copper BCurated
Metal bindingi381 – 3811Iron (heme A3 axial ligand)Curated
Metal bindingi383 – 3831Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Encoded oniMitochondrion
OrganismiAllomyces macrogynus
Taxonomic identifieri28583 [NCBI]
Taxonomic lineageiEukaryotaFungiBlastocladiomycotaBlastocladiomycetesBlastocladialesBlastocladiaceaeAllomyces

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. plasma membrane Source: InterPro
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Cytochrome c oxidase subunit 1PRO_0000183279Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki246 ↔ 2501'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP80440.
SMRiP80440. Positions 7-529.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence AnalysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence AnalysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence AnalysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence AnalysisAdd
BLAST
Transmembranei343 – 36321HelicalSequence AnalysisAdd
BLAST
Transmembranei382 – 40221HelicalSequence AnalysisAdd
BLAST
Transmembranei417 – 43721HelicalSequence AnalysisAdd
BLAST
Transmembranei461 – 48121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80440-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFQRNTVYRW LFSTNAKDIG TLYLVFSIFA GMIGTAFSVL IRFELAGPGV
60 70 80 90 100
QYLYGDHQLY NVIITAHAFI MIFFLVMPAM LGGFGNYFVP IMIGAPDMAF
110 120 130 140 150
PRLNNISFWL LPPSLILLVG SAFVEQGAGT GWTVYPPLSS IGFHSGGSVD
160 170 180 190 200
LAIFSLHLAG ISSMLGSINF ITTILNMRAP GMTMHKLPLF VWSILITAIL
210 220 230 240 250
LLLSLPVLAG AITMLLTDRN LNTTFYDPAG GGDPVLYQHL FWFFGHPEVY
260 270 280 290 300
IIIIPGFGII SQVISTFSRK PIFGYLGMVY AMASIGILGF IVWSHHMYTV
310 320 330 340 350
GLDVDTRAYF TAATMIIAVP TGIKIFSWLA TLYGGNILYR TPAYFALGFL
360 370 380 390 400
FLFTIGGVTG VMLANASLDV ALHDTYYVVA HFHYVLSMGA VFALFAGFYY
410 420 430 440 450
WIGKITGKQY NEFWGQVHFW TMFIGVNVTF FPMHFLGLNG MPRRIPDYPD
460 470 480 490 500
AFTQWNVISS FGSIISIVST IVFLYGLYLT LSQPAVSLAN NYWHVPSFFS
510 520 530
STHSLYGDTT QTSSSLEWVL PSPPAFHAFN HLPVQS
Length:536
Mass (Da):59,445
Last modified:November 1, 1995 - v1
Checksum:i7DE8DF291EAE4091
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41288 Genomic DNA. Translation: AAC49234.1.
PIRiS63651.
RefSeqiNP_043733.1. NC_001715.1.

Genome annotation databases

GeneIDi801856.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41288 Genomic DNA. Translation: AAC49234.1 .
PIRi S63651.
RefSeqi NP_043733.1. NC_001715.1.

3D structure databases

ProteinModelPortali P80440.
SMRi P80440. Positions 7-529.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 801856.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular phylogeny of Allomyces macrogynus: congruency between nuclear ribosomal RNA- and mitochondrial protein-based trees."
    Paquin B., Forget L., Roewer I., Lang B.F.
    J. Mol. Evol. 41:657-665(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 46923 / Burma 3-35 (35OC).
  2. "The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus."
    Paquin B., Lang B.F.
    J. Mol. Biol. 255:688-701(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 46923 / Burma 3-35 (35OC).

Entry informationi

Entry nameiCOX1_ALLMA
AccessioniPrimary (citable) accession number: P80440
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3