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Protein

Cytochrome c oxidase subunit 7C, mitochondrial

Gene

Cox7c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIIA
Cytochrome c oxidase polypeptide VIIc
Gene namesi
Name:Cox7c
Synonyms:Cox7c1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi2300145 Cox7c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 33Mitochondrial matrixBy similarityAdd BLAST17
Transmembranei34 – 60HelicalBy similarityAdd BLAST27
Topological domaini61 – 63Mitochondrial intermembraneBy similarity3

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16Mitochondrion1 PublicationAdd BLAST16
ChainiPRO_000019704417 – 63Cytochrome c oxidase subunit 7C, mitochondrialAdd BLAST47

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25N6-acetyllysine; alternateBy similarity1
Modified residuei25N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP80432
PRIDEiP80432

PTM databases

CarbonylDBiP80432
iPTMnetiP80432
PhosphoSitePlusiP80432

Expressioni

Gene expression databases

BgeeiENSRNOG00000030237
GenevisibleiP80432 RN

Interactioni

Protein-protein interaction databases

CORUMiP80432
STRINGi10116.ENSRNOP00000049222

Structurei

3D structure databases

ProteinModelPortaliP80432
SMRiP80432
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIc family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4527 Eukaryota
ENOG4112B97 LUCA
GeneTreeiENSGT00390000018086
HOGENOMiHOG000237276
HOVERGENiHBG051093
InParanoidiP80432
KOiK02272
OMAiVRHQILK
OrthoDBiEOG091G16OJ
PhylomeDBiP80432
TreeFamiTF105069

Family and domain databases

CDDicd00929 Cyt_c_Oxidase_VIIc, 1 hit
Gene3Di4.10.49.10, 1 hit
InterProiView protein in InterPro
IPR004202 COX7C/Cox8
IPR036636 COX7C/Cox8_sf
PANTHERiPTHR13313 PTHR13313, 1 hit
PfamiView protein in Pfam
PF02935 COX7C, 1 hit
SUPFAMiSSF81427 SSF81427, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGQSIRRFT TSVVRRSHYE EGPGKNLPFS VENKWRLLLM MTVYFGSGFA
60
APFFIVRHQL LKK
Length:63
Mass (Da):7,375
Last modified:October 19, 2011 - v2
Checksum:iCB72704ABFEB2C7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473955 Genomic DNA Translation: EDM09981.1
BC166894 mRNA Translation: AAI66894.1
PIRiS65388
RefSeqiNP_001128177.1, NM_001134705.1
UniGeneiRn.105968

Genome annotation databases

EnsembliENSRNOT00000051895; ENSRNOP00000049222; ENSRNOG00000030237
GeneIDi100188937
KEGGirno:100188937
UCSCiRGD:2300145 rat

Similar proteinsi

Entry informationi

Entry nameiCOX7C_RAT
AccessioniPrimary (citable) accession number: P80432
Secondary accession number(s): B2RYT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 19, 2011
Last modified: May 23, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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