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Protein

Cytochrome c oxidase subunit 7C, mitochondrial

Gene

Cox7c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIIA
Cytochrome c oxidase polypeptide VIIc
Gene namesi
Name:Cox7c
Synonyms:Cox7c1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2300145. Cox7c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 33Mitochondrial matrixBy similarityAdd BLAST17
Transmembranei34 – 60HelicalBy similarityAdd BLAST27
Topological domaini61 – 63Mitochondrial intermembraneBy similarity3

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16Mitochondrion1 PublicationAdd BLAST16
ChainiPRO_000019704417 – 63Cytochrome c oxidase subunit 7C, mitochondrialAdd BLAST47

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25N6-acetyllysine; alternateBy similarity1
Modified residuei25N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP80432.
PRIDEiP80432.

PTM databases

iPTMnetiP80432.
PhosphoSitePlusiP80432.

Expressioni

Gene expression databases

BgeeiENSRNOG00000030237.
GenevisibleiP80432. RN.

Interactioni

Protein-protein interaction databases

CORUMiP80432.
STRINGi10116.ENSRNOP00000049222.

Structurei

3D structure databases

ProteinModelPortaliP80432.
SMRiP80432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIc family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4527. Eukaryota.
ENOG4112B97. LUCA.
GeneTreeiENSGT00390000018086.
HOGENOMiHOG000237276.
HOVERGENiHBG051093.
InParanoidiP80432.
KOiK02272.
OMAiVRHQILK.
OrthoDBiEOG091G16OJ.
PhylomeDBiP80432.
TreeFamiTF105069.

Family and domain databases

CDDicd00929. Cyt_c_Oxidase_VIIc. 1 hit.
Gene3Di4.10.49.10. 1 hit.
InterProiView protein in InterPro
IPR004202. COX7C/Cox8.
IPR036636. COX7C/Cox8_sf.
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiView protein in Pfam
PF02935. COX7C. 1 hit.
SUPFAMiSSF81427. SSF81427. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGQSIRRFT TSVVRRSHYE EGPGKNLPFS VENKWRLLLM MTVYFGSGFA
60
APFFIVRHQL LKK
Length:63
Mass (Da):7,375
Last modified:October 19, 2011 - v2
Checksum:iCB72704ABFEB2C7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473955 Genomic DNA. Translation: EDM09981.1.
BC166894 mRNA. Translation: AAI66894.1.
PIRiS65388.
RefSeqiNP_001128177.1. NM_001134705.1.
UniGeneiRn.105968.

Genome annotation databases

EnsembliENSRNOT00000051895; ENSRNOP00000049222; ENSRNOG00000030237.
GeneIDi100188937.
KEGGirno:100188937.
UCSCiRGD:2300145. rat.

Similar proteinsi

Entry informationi

Entry nameiCOX7C_RAT
AccessioniPrimary (citable) accession number: P80432
Secondary accession number(s): B2RYT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 19, 2011
Last modified: November 22, 2017
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families