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Protein

Cytochrome c oxidase subunit 7C, mitochondrial

Gene

Cox7c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIIA
Cytochrome c oxidase polypeptide VIIc
Gene namesi
Name:Cox7c
Synonyms:Cox7c1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2300145. Cox7c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 3317Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei34 – 6027HelicalBy similarityAdd
BLAST
Topological domaini61 – 633Mitochondrial intermembraneBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1616Mitochondrion1 PublicationAdd
BLAST
Chaini17 – 6347Cytochrome c oxidase subunit 7C, mitochondrialPRO_0000197044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251N6-acetyllysine; alternateBy similarity
Modified residuei25 – 251N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP80432.
PRIDEiP80432.

PTM databases

iPTMnetiP80432.

Expressioni

Gene expression databases

GenevisibleiP80432. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049222.

Structurei

3D structure databases

ProteinModelPortaliP80432.
SMRiP80432. Positions 17-63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIc family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4527. Eukaryota.
ENOG4112B97. LUCA.
GeneTreeiENSGT00390000018086.
HOGENOMiHOG000237276.
HOVERGENiHBG051093.
InParanoidiP80432.
KOiK02272.
OMAiVRHQILK.
OrthoDBiEOG73JKZF.
PhylomeDBiP80432.
TreeFamiTF105069.

Family and domain databases

Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGQSIRRFT TSVVRRSHYE EGPGKNLPFS VENKWRLLLM MTVYFGSGFA
60
APFFIVRHQL LKK
Length:63
Mass (Da):7,375
Last modified:October 19, 2011 - v2
Checksum:iCB72704ABFEB2C7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473955 Genomic DNA. Translation: EDM09981.1.
BC166894 mRNA. Translation: AAI66894.1.
PIRiS65388.
RefSeqiNP_001128177.1. NM_001134705.1.
UniGeneiRn.105968.

Genome annotation databases

EnsembliENSRNOT00000051895; ENSRNOP00000049222; ENSRNOG00000030237.
GeneIDi100188937.
KEGGirno:100188937.
UCSCiRGD:2300145. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473955 Genomic DNA. Translation: EDM09981.1.
BC166894 mRNA. Translation: AAI66894.1.
PIRiS65388.
RefSeqiNP_001128177.1. NM_001134705.1.
UniGeneiRn.105968.

3D structure databases

ProteinModelPortaliP80432.
SMRiP80432. Positions 17-63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049222.

PTM databases

iPTMnetiP80432.

Proteomic databases

PaxDbiP80432.
PRIDEiP80432.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000051895; ENSRNOP00000049222; ENSRNOG00000030237.
GeneIDi100188937.
KEGGirno:100188937.
UCSCiRGD:2300145. rat.

Organism-specific databases

CTDi1350.
RGDi2300145. Cox7c.

Phylogenomic databases

eggNOGiKOG4527. Eukaryota.
ENOG4112B97. LUCA.
GeneTreeiENSGT00390000018086.
HOGENOMiHOG000237276.
HOVERGENiHBG051093.
InParanoidiP80432.
KOiK02272.
OMAiVRHQILK.
OrthoDBiEOG73JKZF.
PhylomeDBiP80432.
TreeFamiTF105069.

Miscellaneous databases

PROiP80432.

Gene expression databases

GenevisibleiP80432. RN.

Family and domain databases

Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary anterior lobe.
  3. "Cytochrome-c oxidase in developing rat heart. Enzymic properties and amino-terminal sequences suggest identity of the fetal heart and the adult liver isoform."
    Schaegger H., Noack H., Halangk W., Brandt U., von Jagow G.
    Eur. J. Biochem. 230:235-241(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 17-26.
    Strain: Wistar.
    Tissue: Heart and Liver.

Entry informationi

Entry nameiCOX7C_RAT
AccessioniPrimary (citable) accession number: P80432
Secondary accession number(s): B2RYT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 19, 2011
Last modified: June 8, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.