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Protein

Cytochrome c oxidase subunit 7B, mitochondrial

Gene

Cox7b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIb
Gene namesi
Name:Cox7b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi727789. Cox7b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 328Mitochondrial matrixBy similarity
Transmembranei33 – 5927HelicalBy similarityAdd
BLAST
Topological domaini60 – 8021Mitochondrial intermembraneBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424Mitochondrion1 PublicationAdd
BLAST
Chaini25 – 8056Cytochrome c oxidase subunit 7B, mitochondrialPRO_0000006160Add
BLAST

Proteomic databases

PaxDbiP80431.

PTM databases

iPTMnetiP80431.
PhosphoSiteiP80431.

Expressioni

Gene expression databases

BgeeiENSRNOG00000028451.
GenevisibleiP80431. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054370.

Structurei

3D structure databases

ProteinModelPortaliP80431.
SMRiP80431. Positions 31-78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIb family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3GK. Eukaryota.
ENOG4112BN9. LUCA.
GeneTreeiENSGT00390000012178.
HOGENOMiHOG000059529.
HOVERGENiHBG051092.
InParanoidiP80431.
KOiK02271.
OMAiAVWAYTA.
OrthoDBiEOG091G1342.
PhylomeDBiP80431.
TreeFamiTF105068.

Family and domain databases

Gene3Di4.10.51.10. 1 hit.
InterProiIPR008433. Cyt_c_oxidase_suVIIB.
IPR023272. Cyt_c_oxidase_suVIIB_dom.
[Graphical view]
PANTHERiPTHR16716. PTHR16716. 1 hit.
PfamiPF05392. COX7B. 1 hit.
[Graphical view]
SUPFAMiSSF81423. SSF81423. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLAKNALS RLQVRSIQQV VARQSHQKKT PTFHDKYGNA VLAGGSIFCI
60 70 80
SAWTYTATQI GIEWNLSPVG RVTPKEWRDQ
Length:80
Mass (Da):8,995
Last modified:November 28, 2006 - v3
Checksum:iA0E9B8E8BD6CCBF7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91L → I in AAP92332 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY339885 mRNA. Translation: AAP92332.1.
BC079123 mRNA. Translation: AAH79123.1.
PIRiS65387.
RefSeqiNP_877971.2. NM_182819.2.
UniGeneiRn.2026.

Genome annotation databases

EnsembliENSRNOT00000090007; ENSRNOP00000074109; ENSRNOG00000054689.
GeneIDi303393.
KEGGirno:303393.
UCSCiRGD:727789. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY339885 mRNA. Translation: AAP92332.1.
BC079123 mRNA. Translation: AAH79123.1.
PIRiS65387.
RefSeqiNP_877971.2. NM_182819.2.
UniGeneiRn.2026.

3D structure databases

ProteinModelPortaliP80431.
SMRiP80431. Positions 31-78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054370.

PTM databases

iPTMnetiP80431.
PhosphoSiteiP80431.

Proteomic databases

PaxDbiP80431.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000090007; ENSRNOP00000074109; ENSRNOG00000054689.
GeneIDi303393.
KEGGirno:303393.
UCSCiRGD:727789. rat.

Organism-specific databases

CTDi1349.
RGDi727789. Cox7b.

Phylogenomic databases

eggNOGiENOG410J3GK. Eukaryota.
ENOG4112BN9. LUCA.
GeneTreeiENSGT00390000012178.
HOGENOMiHOG000059529.
HOVERGENiHBG051092.
InParanoidiP80431.
KOiK02271.
OMAiAVWAYTA.
OrthoDBiEOG091G1342.
PhylomeDBiP80431.
TreeFamiTF105068.

Miscellaneous databases

PROiP80431.

Gene expression databases

BgeeiENSRNOG00000028451.
GenevisibleiP80431. RN.

Family and domain databases

Gene3Di4.10.51.10. 1 hit.
InterProiIPR008433. Cyt_c_oxidase_suVIIB.
IPR023272. Cyt_c_oxidase_suVIIB_dom.
[Graphical view]
PANTHERiPTHR16716. PTHR16716. 1 hit.
PfamiPF05392. COX7B. 1 hit.
[Graphical view]
SUPFAMiSSF81423. SSF81423. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX7B_RAT
AccessioniPrimary (citable) accession number: P80431
Secondary accession number(s): Q6AYA9, Q7TPH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 28, 2006
Last modified: September 7, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.