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Protein

Cytochrome c oxidase subunit 7B, mitochondrial

Gene

Cox7b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIb
Gene namesi
Name:Cox7b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi727789. Cox7b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 32Mitochondrial matrixBy similarity8
Transmembranei33 – 59HelicalBy similarityAdd BLAST27
Topological domaini60 – 80Mitochondrial intermembraneBy similarityAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24Mitochondrion1 PublicationAdd BLAST24
ChainiPRO_000000616025 – 80Cytochrome c oxidase subunit 7B, mitochondrialAdd BLAST56

Proteomic databases

PaxDbiP80431.
PRIDEiP80431.

PTM databases

iPTMnetiP80431.
PhosphoSitePlusiP80431.

Expressioni

Gene expression databases

BgeeiENSRNOG00000054689.
GenevisibleiP80431. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054370.

Structurei

3D structure databases

ProteinModelPortaliP80431.
SMRiP80431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIb family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3GK. Eukaryota.
ENOG4112BN9. LUCA.
GeneTreeiENSGT00390000012178.
HOGENOMiHOG000059529.
HOVERGENiHBG051092.
InParanoidiP80431.
KOiK02271.
OMAiAVWAYTA.
OrthoDBiEOG091G1342.
PhylomeDBiP80431.
TreeFamiTF105068.

Family and domain databases

Gene3Di4.10.51.10. 1 hit.
InterProiView protein in InterPro
IPR008433. Cyt_c_oxidase_suVIIB.
IPR023272. Cyt_c_oxidase_suVIIB_dom.
PANTHERiPTHR16716. PTHR16716. 1 hit.
PfamiView protein in Pfam
PF05392. COX7B. 1 hit.
SUPFAMiSSF81423. SSF81423. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLAKNALS RLQVRSIQQV VARQSHQKKT PTFHDKYGNA VLAGGSIFCI
60 70 80
SAWTYTATQI GIEWNLSPVG RVTPKEWRDQ
Length:80
Mass (Da):8,995
Last modified:November 28, 2006 - v3
Checksum:iA0E9B8E8BD6CCBF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9L → I in AAP92332 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY339885 mRNA. Translation: AAP92332.1.
BC079123 mRNA. Translation: AAH79123.1.
PIRiS65387.
RefSeqiNP_877971.2. NM_182819.2.
UniGeneiRn.2026.

Genome annotation databases

EnsembliENSRNOT00000090007; ENSRNOP00000074109; ENSRNOG00000054689.
GeneIDi303393.
KEGGirno:303393.
UCSCiRGD:727789. rat.

Similar proteinsi

Entry informationi

Entry nameiCOX7B_RAT
AccessioniPrimary (citable) accession number: P80431
Secondary accession number(s): Q6AYA9, Q7TPH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 28, 2006
Last modified: August 30, 2017
This is version 113 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families