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Protein

Leech-derived tryptase inhibitor C

Gene
N/A
Organism
Hirudo medicinalis (Medicinal leech)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an inhibitor of human tryptase, trypsin and chymotrypsin. Probably acts to block host defense mechanisms.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei8 – 92Reactive bond (tryptase)

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.021.

Names & Taxonomyi

Protein namesi
Recommended name:
Leech-derived tryptase inhibitor C
Short name:
LDTI-C
Cleaved into the following 2 chains:
OrganismiHirudo medicinalis (Medicinal leech)
Taxonomic identifieri6421 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataHirudinidaHirudineaArhynchobdellidaHirudiniformesHirudinidaeHirudo

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4646Leech-derived tryptase inhibitor CPRO_0000045882Add
BLAST
Chaini1 – 4343Leech-derived tryptase inhibitor BPRO_0000045883Add
BLAST
Chaini1 – 4242Leech-derived tryptase inhibitor APRO_0000045884Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi4 ↔ 29
Disulfide bondi6 ↔ 25
Disulfide bondi14 ↔ 40

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

DIPiDIP-6084N.
MINTiMINT-1526663.

Structurei

Secondary structure

1
46
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 73Combined sources
Beta strandi13 – 153Combined sources
Beta strandi20 – 234Combined sources
Helixi24 – 307Combined sources
Beta strandi36 – 383Combined sources
Beta strandi41 – 433Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AN1X-ray2.03I1-46[»]
1LDTX-ray1.90L1-46[»]
2KMONMR-A1-44[»]
2KMPNMR-A1-44[»]
2KMQNMR-A1-44[»]
2KMRNMR-A1-44[»]
ProteinModelPortaliP80424.
SMRiP80424. Positions 1-46.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80424.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4242Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF00050. Kazal_1. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
KKVCACPKIL KPVCGSDGRT YANSCIARCN GVSIKSEGSC PTGILN
Length:46
Mass (Da):4,744
Last modified:February 1, 1995 - v1
Checksum:i9FC4383FF5C009A1
GO

Sequence databases

PIRiS50015.

Cross-referencesi

Sequence databases

PIRiS50015.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AN1X-ray2.03I1-46[»]
1LDTX-ray1.90L1-46[»]
2KMONMR-A1-44[»]
2KMPNMR-A1-44[»]
2KMQNMR-A1-44[»]
2KMRNMR-A1-44[»]
ProteinModelPortaliP80424.
SMRiP80424. Positions 1-46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6084N.
MINTiMINT-1526663.

Protein family/group databases

MEROPSiI01.021.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP80424.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF00050. Kazal_1. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLDTI_HIRME
AccessioniPrimary (citable) accession number: P80424
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 11, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.