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Protein

Immunomodulatory protein FIP-Fve

Gene
N/A
Organism
Flammulina velutipes (Agaricus velutipes)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Lectin with specificity for complex cell-surface carbohydrates. Possesses immunomodulatory activity, stimulates lymphocyte mitogenesis, suppresses systemic anaphylaxis reactions and edema, enhances transcription of IL-2, IFN-gamma and TNF-alpha and hemagglutinates red blood cells.

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of immune system process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Immunomodulatory protein FIP-Fve
OrganismiFlammulina velutipes (Agaricus velutipes)
Taxonomic identifieri38945 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPhysalacriaceaeFlammulina

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 114114Immunomodulatory protein FIP-FvePRO_0000087390Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1
114
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 1312Combined sources
Beta strandi15 – 195Combined sources
Beta strandi23 – 264Combined sources
Beta strandi32 – 409Combined sources
Beta strandi48 – 536Combined sources
Beta strandi56 – 616Combined sources
Beta strandi72 – 754Combined sources
Helixi76 – 783Combined sources
Turni79 – 824Combined sources
Beta strandi91 – 966Combined sources
Beta strandi98 – 1003Combined sources
Beta strandi105 – 1117Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OSYX-ray1.70A/B1-114[»]
ProteinModelPortaliP80412.
SMRiP80412. Positions 1-114.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80412.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR015339. Immunomodulatory_FIP-Fve_fun.
[Graphical view]
PfamiPF09259. Fve. 1 hit.
[Graphical view]
ProDomiPD030553. Immunomodulatory_FIP-Fve_fun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF101542. SSF101542. 1 hit.

Sequencei

Sequence statusi: Complete.

P80412-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SATSLTFQLA YLVKKIDFDY TPNWGRGTPS SYIDNLTFPK VLTDKKYSYR
60 70 80 90 100
VVVNGSDLGV ESNFAVTPSG GQTINFLQYN KGYGVADTKT IQVFVVIPDT
110
GNSEEYIIAE WKKT
Length:114
Mass (Da):12,704
Last modified:February 1, 1995 - v1
Checksum:iD38C641DCC112A94
GO

Sequence databases

PIRiS69147.

Cross-referencesi

Sequence databases

PIRiS69147.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OSYX-ray1.70A/B1-114[»]
ProteinModelPortaliP80412.
SMRiP80412. Positions 1-114.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP80412.

Family and domain databases

InterProiIPR015339. Immunomodulatory_FIP-Fve_fun.
[Graphical view]
PfamiPF09259. Fve. 1 hit.
[Graphical view]
ProDomiPD030553. Immunomodulatory_FIP-Fve_fun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF101542. SSF101542. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence."
    Ko J.-L., Hsu C.-I., Lin R.-H., Kao C.-L., Lin J.-Y.
    Eur. J. Biochem. 228:244-249(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, ACETYLATION AT SER-1.
  2. "A 1.7A structure of Fve, a member of the new fungal immunomodulatory protein family."
    Paaventhan P., Joseph J.S., Seow S.V., Vaday S., Robinson H., Chua K.Y., Kolatkar P.R.
    J. Mol. Biol. 332:461-470(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).

Entry informationi

Entry nameiFVE_FLAVE
AccessioniPrimary (citable) accession number: P80412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.