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P80412

- FVE_FLAVE

UniProt

P80412 - FVE_FLAVE

Protein

Immunomodulatory protein FIP-Fve

Gene
N/A
Organism
Flammulina velutipes (Agaricus velutipes)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Lectin with specificity for complex cell-surface carbohydrates. Possesses immunomodulatory activity, stimulates lymphocyte mitogenesis, suppresses systemic anaphylaxis reactions and edema, enhances transcription of IL-2, IFN-gamma and TNF-alpha and hemagglutinates red blood cells.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. regulation of immune system process Source: InterPro

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Immunomodulatory protein FIP-Fve
    OrganismiFlammulina velutipes (Agaricus velutipes)
    Taxonomic identifieri38945 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPhysalacriaceaeFlammulina

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 114114Immunomodulatory protein FIP-FvePRO_0000087390Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    Secondary structure

    1
    114
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 1312
    Beta strandi15 – 195
    Beta strandi23 – 264
    Beta strandi32 – 409
    Beta strandi48 – 536
    Beta strandi56 – 616
    Beta strandi72 – 754
    Helixi76 – 783
    Turni79 – 824
    Beta strandi91 – 966
    Beta strandi98 – 1003
    Beta strandi105 – 1117

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OSYX-ray1.70A/B1-114[»]
    ProteinModelPortaliP80412.
    SMRiP80412. Positions 1-114.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP80412.

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR015339. Immunomodulatory_FIP-Fve_fun.
    [Graphical view]
    PfamiPF09259. Fve. 1 hit.
    [Graphical view]
    ProDomiPD030553. Immunomodulatory_FIP-Fve_fun. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF101542. SSF101542. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P80412-1 [UniParc]FASTAAdd to Basket

    « Hide

    SATSLTFQLA YLVKKIDFDY TPNWGRGTPS SYIDNLTFPK VLTDKKYSYR    50
    VVVNGSDLGV ESNFAVTPSG GQTINFLQYN KGYGVADTKT IQVFVVIPDT 100
    GNSEEYIIAE WKKT 114
    Length:114
    Mass (Da):12,704
    Last modified:February 1, 1995 - v1
    Checksum:iD38C641DCC112A94
    GO

    Sequence databases

    PIRiS69147.

    Cross-referencesi

    Sequence databases

    PIRi S69147.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OSY X-ray 1.70 A/B 1-114 [» ]
    ProteinModelPortali P80412.
    SMRi P80412. Positions 1-114.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P80412.

    Family and domain databases

    InterProi IPR015339. Immunomodulatory_FIP-Fve_fun.
    [Graphical view ]
    Pfami PF09259. Fve. 1 hit.
    [Graphical view ]
    ProDomi PD030553. Immunomodulatory_FIP-Fve_fun. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF101542. SSF101542. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence."
      Ko J.-L., Hsu C.-I., Lin R.-H., Kao C.-L., Lin J.-Y.
      Eur. J. Biochem. 228:244-249(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, ACETYLATION AT SER-1.
    2. "A 1.7A structure of Fve, a member of the new fungal immunomodulatory protein family."
      Paaventhan P., Joseph J.S., Seow S.V., Vaday S., Robinson H., Chua K.Y., Kolatkar P.R.
      J. Mol. Biol. 332:461-470(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).

    Entry informationi

    Entry nameiFVE_FLAVE
    AccessioniPrimary (citable) accession number: P80412
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3