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P80412 (FVE_FLAVE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunomodulatory protein FIP-Fve
OrganismFlammulina velutipes (Agaricus velutipes)
Taxonomic identifier38945 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPhysalacriaceaeFlammulina

Protein attributes

Sequence length114 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Lectin with specificity for complex cell-surface carbohydrates. Possesses immunomodulatory activity, stimulates lymphocyte mitogenesis, suppresses systemic anaphylaxis reactions and edema, enhances transcription of IL-2, IFN-gamma and TNF-alpha and hemagglutinates red blood cells.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the fungal immunomodulatory protein (FIP) family.

Ontologies

Keywords
   LigandLectin
   PTMAcetylation
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological_processregulation of immune system process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 114114Immunomodulatory protein FIP-Fve
PRO_0000087390

Amino acid modifications

Modified residue11N-acetylserine Ref.1

Secondary structure

....................... 114
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P80412 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: D38C641DCC112A94

FASTA11412,704
        10         20         30         40         50         60 
SATSLTFQLA YLVKKIDFDY TPNWGRGTPS SYIDNLTFPK VLTDKKYSYR VVVNGSDLGV 

        70         80         90        100        110 
ESNFAVTPSG GQTINFLQYN KGYGVADTKT IQVFVVIPDT GNSEEYIIAE WKKT 

« Hide

References

[1]"A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence."
Ko J.-L., Hsu C.-I., Lin R.-H., Kao C.-L., Lin J.-Y.
Eur. J. Biochem. 228:244-249(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, ACETYLATION AT SER-1.
[2]"A 1.7A structure of Fve, a member of the new fungal immunomodulatory protein family."
Paaventhan P., Joseph J.S., Seow S.V., Vaday S., Robinson H., Chua K.Y., Kolatkar P.R.
J. Mol. Biol. 332:461-470(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).

Cross-references

Sequence databases

PIRS69147.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OSYX-ray1.70A/B1-114[»]
ProteinModelPortalP80412.
SMRP80412. Positions 1-114.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR015339. Immunomodulatory_FIP-Fve_fun.
[Graphical view]
PfamPF09259. Fve. 1 hit.
[Graphical view]
ProDomPD030553. Immunomodulatory_FIP-Fve_fun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF101542. SSF101542. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP80412.

Entry information

Entry nameFVE_FLAVE
AccessionPrimary (citable) accession number: P80412
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 16, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references