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P80412

- FVE_FLAVE

UniProt

P80412 - FVE_FLAVE

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Protein

Immunomodulatory protein FIP-Fve

Gene
N/A
Organism
Flammulina velutipes (Agaricus velutipes)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Lectin with specificity for complex cell-surface carbohydrates. Possesses immunomodulatory activity, stimulates lymphocyte mitogenesis, suppresses systemic anaphylaxis reactions and edema, enhances transcription of IL-2, IFN-gamma and TNF-alpha and hemagglutinates red blood cells.

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro

GO - Biological processi

  1. regulation of immune system process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Immunomodulatory protein FIP-Fve
OrganismiFlammulina velutipes (Agaricus velutipes)
Taxonomic identifieri38945 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPhysalacriaceaeFlammulina

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 114114Immunomodulatory protein FIP-FvePRO_0000087390Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1
114
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 1312
Beta strandi15 – 195
Beta strandi23 – 264
Beta strandi32 – 409
Beta strandi48 – 536
Beta strandi56 – 616
Beta strandi72 – 754
Helixi76 – 783
Turni79 – 824
Beta strandi91 – 966
Beta strandi98 – 1003
Beta strandi105 – 1117

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OSYX-ray1.70A/B1-114[»]
ProteinModelPortaliP80412.
SMRiP80412. Positions 1-114.

Miscellaneous databases

EvolutionaryTraceiP80412.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR015339. Immunomodulatory_FIP-Fve_fun.
[Graphical view]
PfamiPF09259. Fve. 1 hit.
[Graphical view]
ProDomiPD030553. Immunomodulatory_FIP-Fve_fun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF101542. SSF101542. 1 hit.

Sequencei

Sequence statusi: Complete.

P80412-1 [UniParc]FASTAAdd to Basket

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SATSLTFQLA YLVKKIDFDY TPNWGRGTPS SYIDNLTFPK VLTDKKYSYR    50
VVVNGSDLGV ESNFAVTPSG GQTINFLQYN KGYGVADTKT IQVFVVIPDT 100
GNSEEYIIAE WKKT 114
Length:114
Mass (Da):12,704
Last modified:February 1, 1995 - v1
Checksum:iD38C641DCC112A94
GO

Sequence databases

PIRiS69147.

Cross-referencesi

Sequence databases

PIRi S69147.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OSY X-ray 1.70 A/B 1-114 [» ]
ProteinModelPortali P80412.
SMRi P80412. Positions 1-114.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P80412.

Family and domain databases

InterProi IPR015339. Immunomodulatory_FIP-Fve_fun.
[Graphical view ]
Pfami PF09259. Fve. 1 hit.
[Graphical view ]
ProDomi PD030553. Immunomodulatory_FIP-Fve_fun. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF101542. SSF101542. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence."
    Ko J.-L., Hsu C.-I., Lin R.-H., Kao C.-L., Lin J.-Y.
    Eur. J. Biochem. 228:244-249(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, ACETYLATION AT SER-1.
  2. "A 1.7A structure of Fve, a member of the new fungal immunomodulatory protein family."
    Paaventhan P., Joseph J.S., Seow S.V., Vaday S., Robinson H., Chua K.Y., Kolatkar P.R.
    J. Mol. Biol. 332:461-470(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).

Entry informationi

Entry nameiFVE_FLAVE
AccessioniPrimary (citable) accession number: P80412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 16, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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