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P80403

- IAAI_AMAHP

UniProt

P80403 - IAAI_AMAHP

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Protein
Alpha-amylase inhibitor AAI
Gene
AAI
Organism
Amaranthus hypochondriacus (Prince-of-Wales feather)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Alpha-amylase inhibitor. It is active against alpha-amylases from Tribolium castaneum and Prostephanus truncatus larvae.

GO - Molecular functioni

  1. alpha-amylase inhibitor activity Source: UniProtKB-KW
  2. endopeptidase inhibitor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Alpha-amylase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-amylase inhibitor AAI
Gene namesi
Name:AAI
OrganismiAmaranthus hypochondriacus (Prince-of-Wales feather)
Taxonomic identifieri28502 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesAmaranthaceaeAmaranthus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3232Alpha-amylase inhibitor AAI
PRO_0000084123Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi1 ↔ 182 Publications
Disulfide bondi8 ↔ 232 Publications
Disulfide bondi17 ↔ 312 Publications

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Endosperm.

Interactioni

Protein-protein interaction databases

MINTiMINT-106908.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 83
Helixi10 – 134
Beta strandi26 – 316

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CLVX-ray2.00I1-32[»]
1HTXNMR-A1-32[»]
1QFDNMR-A1-32[»]
ProteinModelPortaliP80403.
SMRiP80403. Positions 1-32.

Miscellaneous databases

EvolutionaryTraceiP80403.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR011052. Proteinase_amylase_inhib_dom.
[Graphical view]
SUPFAMiSSF57027. SSF57027. 1 hit.

Sequencei

Sequence statusi: Complete.

P80403-1 [UniParc]FASTAAdd to Basket

« Hide

CIPKWNRCGP KMDGVPCCEP YTCTSDYYGN CS                      32
Length:32
Mass (Da):3,592
Last modified:February 1, 1995 - v1
Checksum:i4B9B744B58C39BE3
GO

Sequence databases

PIRiA54845.

Cross-referencesi

Sequence databases

PIRi A54845.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1CLV X-ray 2.00 I 1-32 [» ]
1HTX NMR - A 1-32 [» ]
1QFD NMR - A 1-32 [» ]
ProteinModelPortali P80403.
SMRi P80403. Positions 1-32.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-106908.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P80403.

Family and domain databases

InterProi IPR011052. Proteinase_amylase_inhib_dom.
[Graphical view ]
SUPFAMi SSF57027. SSF57027. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A novel alpha-amylase inhibitor from amaranth (Amaranthus hypocondriacus) seeds."
    Chagolla-Lopez A., Blanco-Labra A., Patthy A., Sanchez R., Pongor S.
    J. Biol. Chem. 269:23675-23680(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, DISULFIDE BONDS.
    Tissue: Seed.
  2. "Solution structure of the major alpha-amylase inhibitor of the crop plant amaranth."
    Lu S., Deng P., Liu X., Luo J., Han R., Gu X., Liang S., Wang X., Li F., Lozanov V., Patthy A., Pongor S.
    J. Biol. Chem. 274:20473-20478(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, REVISION OF DISULFIDE BONDS.
    Tissue: Seed.

Entry informationi

Entry nameiIAAI_AMAHP
AccessioniPrimary (citable) accession number: P80403
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3