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P80403 (IAAI_AMAHP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-amylase inhibitor AAI
Gene names
Name:AAI
OrganismAmaranthus hypochondriacus (Prince-of-Wales feather)
Taxonomic identifier28502 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesAmaranthaceaeAmaranthus

Protein attributes

Sequence length32 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Alpha-amylase inhibitor. It is active against alpha-amylases from Tribolium castaneum and Prostephanus truncatus larvae.

Tissue specificity

Endosperm.

Domain

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3232Alpha-amylase inhibitor AAI
PRO_0000084123

Amino acid modifications

Disulfide bond1 ↔ 18 Ref.1 Ref.2
Disulfide bond8 ↔ 23 Ref.1 Ref.2
Disulfide bond17 ↔ 31 Ref.1 Ref.2

Secondary structure

....... 32
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P80403 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 4B9B744B58C39BE3

FASTA323,592
        10         20         30 
CIPKWNRCGP KMDGVPCCEP YTCTSDYYGN CS 

« Hide

References

[1]"A novel alpha-amylase inhibitor from amaranth (Amaranthus hypocondriacus) seeds."
Chagolla-Lopez A., Blanco-Labra A., Patthy A., Sanchez R., Pongor S.
J. Biol. Chem. 269:23675-23680(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, DISULFIDE BONDS.
Tissue: Seed.
[2]"Solution structure of the major alpha-amylase inhibitor of the crop plant amaranth."
Lu S., Deng P., Liu X., Luo J., Han R., Gu X., Liang S., Wang X., Li F., Lozanov V., Patthy A., Pongor S.
J. Biol. Chem. 274:20473-20478(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR, REVISION OF DISULFIDE BONDS.
Tissue: Seed.
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRA54845.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1CLVX-ray2.00I1-32[»]
1HTXNMR-A1-32[»]
1QFDNMR-A1-32[»]
ProteinModelPortalP80403.
SMRP80403. Positions 1-32.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-106908.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011052. Proteinase_amylase_inhib_dom.
[Graphical view]
SUPFAMSSF57027. SSF57027. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP80403.

Entry information

Entry nameIAAI_AMAHP
AccessionPrimary (citable) accession number: P80403
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references