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Protein

Gaegurin-4

Gene

GGN4

Organism
Rugosa rugosa (Japanese wrinkled frog) (Glandirana rugosa)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has a non-hemolytic activity. Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, Antibiotic, Antimicrobial

Protein family/group databases

TCDBi1.C.52.1.3. the dermaseptin (dermaseptin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Gaegurin-4
Gene namesi
Name:GGN4
OrganismiRugosa rugosa (Japanese wrinkled frog) (Glandirana rugosa)
Taxonomic identifieri8410 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRugosa

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 43211 PublicationPRO_0000003455Add
BLAST
Peptidei44 – 8037Gaegurin-4PRO_0000003456Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi74 ↔ 801 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the skin glands.

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1
80
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi45 – 539Combined sources
Turni54 – 574Combined sources
Helixi58 – 647Combined sources
Beta strandi66 – 683Combined sources
Helixi69 – 746Combined sources
Turni75 – 784Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G9LNMR-A44-80[»]
ProteinModelPortaliP80398.
SMRiP80398. Positions 44-80.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80398.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005608.

Family and domain databases

InterProiIPR012521. Antimicrobial_frog_2.
IPR018247. EF_Hand_1_Ca_BS.
IPR004275. Frog_antimicrobial_propeptide.
[Graphical view]
PfamiPF08023. Antimicrobial_2. 1 hit.
PF03032. FSAP_sig_propep. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTMKKSLLF LFFLGTISLS LCEEERSADE DDGGEMTEEE VKRGILDTLK
60 70 80
QFAKGVGKDL VKGAAQGVLS TVSCKLAKTC
Length:80
Mass (Da):8,695
Last modified:November 1, 1997 - v2
Checksum:iD79FC76D2995F4B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261Missing in AAK26444 (PubMed:11004488).Curated
Sequence conflicti78 – 781K → L AA sequence (PubMed:7999137).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22392 mRNA. Translation: AAA64411.1.
AF213015 Genomic DNA. Translation: AAK26444.1.
PIRiS59961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22392 mRNA. Translation: AAA64411.1.
AF213015 Genomic DNA. Translation: AAK26444.1.
PIRiS59961.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G9LNMR-A44-80[»]
ProteinModelPortaliP80398.
SMRiP80398. Positions 44-80.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.52.1.3. the dermaseptin (dermaseptin) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005608.

Miscellaneous databases

EvolutionaryTraceiP80398.

Family and domain databases

InterProiIPR012521. Antimicrobial_frog_2.
IPR018247. EF_Hand_1_Ca_BS.
IPR004275. Frog_antimicrobial_propeptide.
[Graphical view]
PfamiPF08023. Antimicrobial_2. 1 hit.
PF03032. FSAP_sig_propep. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGGN4_RUGRU
AccessioniPrimary (citable) accession number: P80398
Secondary accession number(s): Q91328, Q98TA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: December 9, 2015
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.