P80397 (GGN3_GLARU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gaegurin-3

Gene names

Name:

GGN3

Organism

Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa)

Taxonomic identifier

8410 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Neobatrachia › Ranoidea › Ranidae › Glandirana

Protein attributes

Sequence length	33 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has a non-hemolytic activity. Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa.
Subunit structure	Monomer.
Subcellular location	Secreted.
Tissue specificity	Expressed by the skin glands.
Sequence similarities	Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Amphibian defense peptide Antibiotic Antimicrobial
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 33	33	Gaegurin-3		PRO_0000044654
Amino acid modifications
	Disulfide bond	27 ↔ 33		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P80397 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: C1EA65E2489E5475	FASTA	33	3,309
	10 20 30 GIMSIVKDVA KTAAKEAAKG ALSTLSCKLA KTC

References

[1]	"Antimicrobial peptides from the skin of a Korean frog, Rana rugosa." Park J.M., Jung J.-E., Lee B.J. Biochem. Biophys. Res. Commun. 205:948-954(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Skin secretion.

Cross-references

Sequence databases
PIR	PC2302.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR012521. Antimicrobial_frog_2. [Graphical view]
Pfam	PF08023. Antimicrobial_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GGN3_GLARU

Accession

Primary (citable) accession number: P80397

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program