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Protein

Gaegurin-3

Gene

GGN3

Organism
Rugosa rugosa (Japanese wrinkled frog) (Glandirana rugosa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has a non-hemolytic activity. Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Gaegurin-3
Gene namesi
Name:GGN3
OrganismiRugosa rugosa (Japanese wrinkled frog) (Glandirana rugosa)
Taxonomic identifieri8410 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRugosa

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3333Gaegurin-3PRO_0000044654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 33By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the skin glands.

Interactioni

Subunit structurei

Monomer.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR012521. Antimicrobial_frog_2.
[Graphical view]
PfamiPF08023. Antimicrobial_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
GIMSIVKDVA KTAAKEAAKG ALSTLSCKLA KTC
Length:33
Mass (Da):3,309
Last modified:November 1, 1995 - v1
Checksum:iC1EA65E2489E5475
GO

Sequence databases

PIRiPC2302.

Cross-referencesi

Sequence databases

PIRiPC2302.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR012521. Antimicrobial_frog_2.
[Graphical view]
PfamiPF08023. Antimicrobial_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGGN3_RUGRU
AccessioniPrimary (citable) accession number: P80397
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 16, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.