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P80397 (GGN3_GLARU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gaegurin-3
Gene names
Name:GGN3
OrganismGlandirana rugosa (Japanese wrinkled frog) (Rana rugosa)
Taxonomic identifier8410 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeGlandirana

Protein attributes

Sequence length33 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has a non-hemolytic activity. Has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, fungi and protozoa.

Subunit structure

Monomer.

Subcellular location

Secreted.

Tissue specificity

Expressed by the skin glands.

Sequence similarities

Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionAmphibian defense peptide
Antibiotic
Antimicrobial
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3333Gaegurin-3
PRO_0000044654

Amino acid modifications

Disulfide bond27 ↔ 33 By similarity

Sequences

Sequence LengthMass (Da)Tools
P80397 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: C1EA65E2489E5475

FASTA333,309
        10         20         30 
GIMSIVKDVA KTAAKEAAKG ALSTLSCKLA KTC 

« Hide

References

[1]"Antimicrobial peptides from the skin of a Korean frog, Rana rugosa."
Park J.M., Jung J.-E., Lee B.J.
Biochem. Biophys. Res. Commun. 205:948-954(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Skin secretion.

Cross-references

Sequence databases

PIRPC2302.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR012521. Antimicrobial_frog_2.
[Graphical view]
PfamPF08023. Antimicrobial_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGGN3_GLARU
AccessionPrimary (citable) accession number: P80397
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families