Reviewed, UniProtKB/Swiss-Prot P80389 (AMP1_CHICK)

Names and origin

Protein names	Recommended name:     Antimicrobial peptide CHP1 Alternative name(s):     Chicken heterophil peptide 1
Organism	Gallus gallus (Chicken)
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	39 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function

Bactericidal activity; inhibits Staphylococcus aureus and Escherichia coli.

Ontologies

Keywords
Molecular function	Antibiotic Antimicrobial
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Peptide	1 – 39	39	Antimicrobial peptide CHP1
Amino acid modifications
	Disulfide bond	6 ↔ 28		By similarity
	Disulfide bond	13 ↔ 34		By similarity
	Disulfide bond	18 ↔ 35		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P80389-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 5DDF1051693D254E	FASTA	39	4,480
	10 20 30 GRKSDCFRKS GFCAFLKCPS LTLISGKCSR FYLCCKRIR

References

[1]	"Isolation of antimicrobial peptides from avian heterophils." Evans E.W., Beach G.G., Wunderlich J., Harmon B.G. J. Leukoc. Biol. 56:661-665(1994) [PubMed: 7964174] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSGALG00000022815. Gallus gallus. [Contig view]
Phylogenomic databases
HOVERGEN	P80389.
Family and domain databases
InterPro	IPR001855. Defensin_beta. [Graphical view]
Pfam	PF00711. Defensin_beta. 1 hit. [Graphical view]
ProDom	P80389. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

AMP1_CHICK

Accession

Primary (citable) accession number: P80389

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	July 22, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)