P80389 (AMP1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Antimicrobial peptide CHP1 Alternative name(s): Chicken heterophil peptide 1
Organism	Gallus gallus (Chicken)
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	39 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

Bactericidal activity; inhibits S.aureus and E.coli.

Ontologies

Keywords
Molecular function	Antibiotic Antimicrobial
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 39	39	Antimicrobial peptide CHP1		PRO_0000044771
Amino acid modifications
	Disulfide bond	6 ↔ 28		By similarity
	Disulfide bond	13 ↔ 34		By similarity
	Disulfide bond	18 ↔ 35		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P80389 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 5DDF1051693D254E	FASTA	39	4,480
	10 20 30 GRKSDCFRKS GFCAFLKCPS LTLISGKCSR FYLCCKRIR

References

[1]	"Isolation of antimicrobial peptides from avian heterophils." Evans E.W., Beach G.G., Wunderlich J., Harmon B.G. J. Leukoc. Biol. 56:661-665(1994) [PubMed: 7964174] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
IPI	IPI00584351.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001855. Defensin_beta-typ. [Graphical view]
Pfam	PF00711. Defensin_beta. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMP1_CHICK

Accession

Primary (citable) accession number: P80389

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	September 21, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program