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Protein

Mite group 2 allergen Lep d 2

Gene
N/A
Organism
Lepidoglyphus destructor (Storage mite) (Glycyphagus destructor)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mite group 2 allergen Lep d 2
Alternative name(s):
Allergen Lep d 1
Allergen Lep d I
Allergen: Lep d 2
OrganismiLepidoglyphus destructor (Storage mite) (Glycyphagus destructor)
Taxonomic identifieri36936 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataGlycyphagoideaGlycyphagidaeLepidoglyphus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei439. Lep d 2.
440. Lep d 2.0101.
441. Lep d 2.0201.
442. Lep d 2.0102.
443. Lep d 2.0202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 163 PublicationsAdd BLAST16
ChainiPRO_000001986317 – 141Mite group 2 allergen Lep d 2Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 133By similarity
Disulfide bondi37 ↔ 42By similarity
Disulfide bondi88 ↔ 93By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP80384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 6512
Repeati68 – 6922
Repeati72 – 7332

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 733 X 2 AA repeats of K-V10

Sequence similaritiesi

Belongs to the NPC2 family.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiView protein in InterPro
IPR014756. Ig_E-set.
IPR003172. ML_dom.
PfamiView protein in Pfam
PF02221. E1_DerP2_DerF2. 1 hit.
SMARTiView protein in SMART
SM00737. ML. 1 hit.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKFIALFAL VAVASAGKMT FKDCGHGEVT ELDITGCSGD TCVIHRGEKM
60 70 80 90 100
TLEAKFAANQ DTAKVTIKVL AKVAGTTIQV PGLETDGCKF IKCPVKKGEA
110 120 130 140
LDFIYSGTIP AITPKVKADV TAELIGDHGV MACGTVHGQV E
Length:141
Mass (Da):14,773
Last modified:October 1, 1996 - v2
Checksum:i9AC96F74D6826FA4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26H → K AA sequence (PubMed:1355192).Curated1
Sequence conflicti30T → K AA sequence (PubMed:1355192).Curated1

Polymorphismi

The sequence shown is that of isoform Lep d 2.0101.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti35T → S in Lep d 2.0201 and Lep d 2.0203. 1
Natural varianti48E → Q in Lep d 2.0201 and Lep d 2.0203. 1
Natural varianti53E → D in Lep d 2.0201 and Lep d 2.0203. 1
Natural varianti63A → N in Lep d 2.0201 and Lep d 2.0203. 1
Natural varianti71A → T in Lep d 2.0103. 1
Natural varianti90F → V in Lep d 2.0201 and Lep d 2.0203. 1
Natural varianti91I → L in Lep d 2.0201 and Lep d 2.0203. 1
Natural varianti95V → I in Lep d 2.0201 and Lep d 2.0203. 1
Natural varianti104I → N in Lep d 2.0201 and Lep d 2.0203. 1
Natural varianti106S → G in Lep d 2.0201 and Lep d 2.0203. 1
Natural varianti107G → M in Lep d 2.0201 and Lep d 2.0203. 1
Natural varianti116V → I in Lep d 2.0201 and Lep d 2.0203. 1
Natural varianti118A → V in Lep d 2.0203. 1
Natural varianti125I → V in Lep d 2.0201 and Lep d 2.0203. 1
Natural varianti136V → I in Lep d 2.0201 and Lep d 2.0203. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83875 mRNA. Translation: CAA58755.1.
X83876 mRNA. Translation: CAA58756.1.
X89014 mRNA. Translation: CAA61419.1.
AJ487972 Genomic DNA. Translation: CAD32313.1.
AJ487973 Genomic DNA. Translation: CAD32314.1.
X81399 mRNA. Translation: CAA57160.1.
PIRiS66499.
S66500.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiALL2_LEPDS
AccessioniPrimary (citable) accession number: P80384
Secondary accession number(s): Q8MYK7, Q8MYK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: May 10, 2017
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families