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Protein

Mite group 2 allergen Lep d 2

Gene
N/A
Organism
Lepidoglyphus destructor (Storage mite) (Glycyphagus destructor)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mite group 2 allergen Lep d 2
Alternative name(s):
Allergen Lep d 1
Allergen Lep d I
Allergen: Lep d 2
OrganismiLepidoglyphus destructor (Storage mite) (Glycyphagus destructor)
Taxonomic identifieri36936 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataGlycyphagoideaGlycyphagidaeLepidoglyphus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei439. Lep d 2.
440. Lep d 2.0101.
441. Lep d 2.0201.
442. Lep d 2.0102.
443. Lep d 2.0202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 16163 PublicationsAdd
BLAST
Chaini17 – 141125Mite group 2 allergen Lep d 2PRO_0000019863Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 133By similarity
Disulfide bondi37 ↔ 42By similarity
Disulfide bondi88 ↔ 93By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP80384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 6521
Repeati68 – 6922
Repeati72 – 7323

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 73103 X 2 AA repeats of K-V

Sequence similaritiesi

Belongs to the NPC2 family.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.770. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR003172. ML_dom.
[Graphical view]
PfamiPF02221. E1_DerP2_DerF2. 1 hit.
[Graphical view]
SMARTiSM00737. ML. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKFIALFAL VAVASAGKMT FKDCGHGEVT ELDITGCSGD TCVIHRGEKM
60 70 80 90 100
TLEAKFAANQ DTAKVTIKVL AKVAGTTIQV PGLETDGCKF IKCPVKKGEA
110 120 130 140
LDFIYSGTIP AITPKVKADV TAELIGDHGV MACGTVHGQV E
Length:141
Mass (Da):14,773
Last modified:October 1, 1996 - v2
Checksum:i9AC96F74D6826FA4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261H → K AA sequence (PubMed:1355192).Curated
Sequence conflicti30 – 301T → K AA sequence (PubMed:1355192).Curated

Polymorphismi

The sequence shown is that of isoform Lep d 2.0101.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351T → S in Lep d 2.0201 and Lep d 2.0203.
Natural varianti48 – 481E → Q in Lep d 2.0201 and Lep d 2.0203.
Natural varianti53 – 531E → D in Lep d 2.0201 and Lep d 2.0203.
Natural varianti63 – 631A → N in Lep d 2.0201 and Lep d 2.0203.
Natural varianti71 – 711A → T in Lep d 2.0103.
Natural varianti90 – 901F → V in Lep d 2.0201 and Lep d 2.0203.
Natural varianti91 – 911I → L in Lep d 2.0201 and Lep d 2.0203.
Natural varianti95 – 951V → I in Lep d 2.0201 and Lep d 2.0203.
Natural varianti104 – 1041I → N in Lep d 2.0201 and Lep d 2.0203.
Natural varianti106 – 1061S → G in Lep d 2.0201 and Lep d 2.0203.
Natural varianti107 – 1071G → M in Lep d 2.0201 and Lep d 2.0203.
Natural varianti116 – 1161V → I in Lep d 2.0201 and Lep d 2.0203.
Natural varianti118 – 1181A → V in Lep d 2.0203.
Natural varianti125 – 1251I → V in Lep d 2.0201 and Lep d 2.0203.
Natural varianti136 – 1361V → I in Lep d 2.0201 and Lep d 2.0203.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83875 mRNA. Translation: CAA58755.1.
X83876 mRNA. Translation: CAA58756.1.
X89014 mRNA. Translation: CAA61419.1.
AJ487972 Genomic DNA. Translation: CAD32313.1.
AJ487973 Genomic DNA. Translation: CAD32314.1.
X81399 mRNA. Translation: CAA57160.1.
PIRiS66499.
S66500.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83875 mRNA. Translation: CAA58755.1.
X83876 mRNA. Translation: CAA58756.1.
X89014 mRNA. Translation: CAA61419.1.
AJ487972 Genomic DNA. Translation: CAD32313.1.
AJ487973 Genomic DNA. Translation: CAD32314.1.
X81399 mRNA. Translation: CAA57160.1.
PIRiS66499.
S66500.

3D structure databases

ProteinModelPortaliP80384.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei439. Lep d 2.
440. Lep d 2.0101.
441. Lep d 2.0201.
442. Lep d 2.0102.
443. Lep d 2.0202.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.770. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR003172. ML_dom.
[Graphical view]
PfamiPF02221. E1_DerP2_DerF2. 1 hit.
[Graphical view]
SMARTiSM00737. ML. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "cDNA analysis of the mite allergen Lep d 1 identifies two different isoallergens and variants."
    Schmidt M., van der Ploeg I., Olsson S., van Hage-Hamsten M.
    FEBS Lett. 370:11-14(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (LEP D 2.0101 AND LEP D 2.0201).
  2. "Lep d 2 polymorphisms in wild and cultured Lepidoglyphus destructor mites."
    Kaiser L., Gafvelin G., Johansson E., van Hage-Hamsten M., Rasool O.
    Eur. J. Biochem. 270:646-653(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (LEP D 2.0103 AND LEP D 2.0203).
  3. "Primary structure of Lep d I, the main Lepidoglyphus destructor allergen."
    Varela J., Ventas P., Carreira J., Barbas J.A., Gimenez-Gallego G., Polo F.
    Eur. J. Biochem. 225:93-98(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-141, PROTEIN SEQUENCE OF 17-140.
  4. "Barn allergy: isolation and characterization of the major allergens of storagemites: L. destructor."
    Muthiah R., Miller M., Kagen S.
    J. Allergy Clin. Immunol. 87:326-326(1991)
    Cited for: PROTEIN SEQUENCE OF 17-45.
  5. "N-terminal aminoacid sequence of principal allergen of storage mite Lepidoglyphus destructor."
    van Hage-Hamsten M., Bergman T., Johansson E., Persson B., Joernvall H., Haerfast B., Johansson S.G.O.
    Lancet 340:614-614(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 17-34.

Entry informationi

Entry nameiALL2_LEPDS
AccessioniPrimary (citable) accession number: P80384
Secondary accession number(s): Q8MYK7, Q8MYK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 1, 1996
Last modified: March 4, 2015
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.