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P80378

- RS15_THETH

UniProt

P80378 - RS15_THETH

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Protein

30S ribosomal protein S15

Gene

rpsO

Organism
Thermus thermophilus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
30S ribosomal protein S15UniRule annotation
Gene namesi
Name:rpsOUniRule annotation
Synonyms:rps15UniRule annotation
OrganismiThermus thermophilus
Taxonomic identifieri274 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 898830S ribosomal protein S15PRO_0000115572Add
BLAST

Interactioni

Subunit structurei

Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.UniRule annotation

Protein-protein interaction databases

DIPiDIP-6174N.

Structurei

Secondary structure

1
89
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1511Combined sources
Beta strandi17 – 204Combined sources
Helixi26 – 4520Combined sources
Turni46 – 483Combined sources
Helixi51 – 7323Combined sources
Helixi75 – 817Combined sources
Turni82 – 865Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AB3NMR-A2-89[»]
1DK1X-ray2.80A2-87[»]
1F7YX-ray2.80A1-89[»]
1KUQX-ray2.84A1-87[»]
1PNSX-ray8.70O2-89[»]
1TWTmodel-R2-89[»]
2FKXNMR-A2-89[»]
4BYBX-ray3.35O1-89[»]
ProteinModelPortaliP80378.
SMRiP80378. Positions 2-89.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80378.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S15P family.UniRule annotation

Family and domain databases

Gene3Di1.10.287.10. 1 hit.
HAMAPiMF_01343_B. Ribosomal_S15_B.
InterProiIPR000589. Ribosomal_S15.
IPR005290. Ribosomal_S15_bac-type.
IPR009068. S15_NS1_RNA-bd.
[Graphical view]
PfamiPF00312. Ribosomal_S15. 1 hit.
[Graphical view]
SUPFAMiSSF47060. SSF47060. 1 hit.
TIGRFAMsiTIGR00952. S15_bact. 1 hit.
PROSITEiPS00362. RIBOSOMAL_S15. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80378-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPITKEEKQK VIQEFARFPG DTGSTEVQVA LLTLRINRLS EHLKVHKKDH
60 70 80
HSHRGLLMMV GQRRRLLRYL QREDPERYRA LIEKLGIRG
Length:89
Mass (Da):10,554
Last modified:January 23, 2007 - v3
Checksum:i9DB7E1C533DBF340
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37726 Genomic DNA. Translation: CAA85782.1.
Z84207 Genomic DNA. Translation: CAB06340.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37726 Genomic DNA. Translation: CAA85782.1 .
Z84207 Genomic DNA. Translation: CAB06340.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AB3 NMR - A 2-89 [» ]
1DK1 X-ray 2.80 A 2-87 [» ]
1F7Y X-ray 2.80 A 1-89 [» ]
1KUQ X-ray 2.84 A 1-87 [» ]
1PNS X-ray 8.70 O 2-89 [» ]
1TWT model - R 2-89 [» ]
2FKX NMR - A 2-89 [» ]
4BYB X-ray 3.35 O 1-89 [» ]
ProteinModelPortali P80378.
SMRi P80378. Positions 2-89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-6174N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P80378.

Family and domain databases

Gene3Di 1.10.287.10. 1 hit.
HAMAPi MF_01343_B. Ribosomal_S15_B.
InterProi IPR000589. Ribosomal_S15.
IPR005290. Ribosomal_S15_bac-type.
IPR009068. S15_NS1_RNA-bd.
[Graphical view ]
Pfami PF00312. Ribosomal_S15. 1 hit.
[Graphical view ]
SUPFAMi SSF47060. SSF47060. 1 hit.
TIGRFAMsi TIGR00952. S15_bact. 1 hit.
PROSITEi PS00362. RIBOSOMAL_S15. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ribosomal protein S15 from Thermus thermophilus -- cloning, sequencing, overexpression of the gene and RNA-binding properties of the protein."
    Serganov A., Rak A., Garber M.B., Reinbolt J., Ehresmann B., Ehresmann C., Grunberg-Manago M., Portier C.
    Eur. J. Biochem. 246:291-300(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: VK1.
  2. "Polynucleotide phosphorylase from Thermus thermophilus: cloning, sequencing and expression of the gene and biochemical properties of the enzyme."
    Serganov A.A., Garber M.B., Portier C.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: VK1.
  3. "Solution structure of the ribosomal RNA binding protein S15 from Thermus thermophilus."
    Berglund H., Rak A., Serganov A., Garber M.B., Haerd T.
    Nat. Struct. Biol. 4:20-23(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  4. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Strain: VK1.
  5. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF S15 AND RRNA.
    Strain: VK1.

Entry informationi

Entry nameiRS15_THETH
AccessioniPrimary (citable) accession number: P80378
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3