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P80378

- RS15_THETH

UniProt

P80378 - RS15_THETH

Protein

30S ribosomal protein S15

Gene

rpsO

Organism
Thermus thermophilus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
    Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.UniRule annotation

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-HAMAP
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    30S ribosomal protein S15UniRule annotation
    Gene namesi
    Name:rpsOUniRule annotation
    Synonyms:rps15UniRule annotation
    OrganismiThermus thermophilus
    Taxonomic identifieri274 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 898830S ribosomal protein S15PRO_0000115572Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.UniRule annotation

    Protein-protein interaction databases

    DIPiDIP-6174N.

    Structurei

    Secondary structure

    1
    89
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 1511
    Beta strandi17 – 204
    Helixi26 – 4520
    Turni46 – 483
    Helixi51 – 7323
    Helixi75 – 817
    Turni82 – 865

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AB3NMR-A2-89[»]
    1DK1X-ray2.80A2-87[»]
    1F7YX-ray2.80A1-89[»]
    1KUQX-ray2.84A1-87[»]
    1PNSX-ray8.70O2-89[»]
    1TWTmodel-R2-89[»]
    2FKXNMR-A2-89[»]
    4BYBX-ray3.35O1-89[»]
    ProteinModelPortaliP80378.
    SMRiP80378. Positions 2-89.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP80378.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S15P family.UniRule annotation

    Family and domain databases

    Gene3Di1.10.287.10. 1 hit.
    HAMAPiMF_01343_B. Ribosomal_S15_B.
    InterProiIPR000589. Ribosomal_S15.
    IPR005290. Ribosomal_S15_bac-type.
    IPR009068. S15_NS1_RNA-bd.
    [Graphical view]
    PfamiPF00312. Ribosomal_S15. 1 hit.
    [Graphical view]
    SUPFAMiSSF47060. SSF47060. 1 hit.
    TIGRFAMsiTIGR00952. S15_bact. 1 hit.
    PROSITEiPS00362. RIBOSOMAL_S15. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80378-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPITKEEKQK VIQEFARFPG DTGSTEVQVA LLTLRINRLS EHLKVHKKDH   50
    HSHRGLLMMV GQRRRLLRYL QREDPERYRA LIEKLGIRG 89
    Length:89
    Mass (Da):10,554
    Last modified:January 23, 2007 - v3
    Checksum:i9DB7E1C533DBF340
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z37726 Genomic DNA. Translation: CAA85782.1.
    Z84207 Genomic DNA. Translation: CAB06340.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z37726 Genomic DNA. Translation: CAA85782.1 .
    Z84207 Genomic DNA. Translation: CAB06340.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AB3 NMR - A 2-89 [» ]
    1DK1 X-ray 2.80 A 2-87 [» ]
    1F7Y X-ray 2.80 A 1-89 [» ]
    1KUQ X-ray 2.84 A 1-87 [» ]
    1PNS X-ray 8.70 O 2-89 [» ]
    1TWT model - R 2-89 [» ]
    2FKX NMR - A 2-89 [» ]
    4BYB X-ray 3.35 O 1-89 [» ]
    ProteinModelPortali P80378.
    SMRi P80378. Positions 2-89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-6174N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P80378.

    Family and domain databases

    Gene3Di 1.10.287.10. 1 hit.
    HAMAPi MF_01343_B. Ribosomal_S15_B.
    InterProi IPR000589. Ribosomal_S15.
    IPR005290. Ribosomal_S15_bac-type.
    IPR009068. S15_NS1_RNA-bd.
    [Graphical view ]
    Pfami PF00312. Ribosomal_S15. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47060. SSF47060. 1 hit.
    TIGRFAMsi TIGR00952. S15_bact. 1 hit.
    PROSITEi PS00362. RIBOSOMAL_S15. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ribosomal protein S15 from Thermus thermophilus -- cloning, sequencing, overexpression of the gene and RNA-binding properties of the protein."
      Serganov A., Rak A., Garber M.B., Reinbolt J., Ehresmann B., Ehresmann C., Grunberg-Manago M., Portier C.
      Eur. J. Biochem. 246:291-300(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: VK1.
    2. "Polynucleotide phosphorylase from Thermus thermophilus: cloning, sequencing and expression of the gene and biochemical properties of the enzyme."
      Serganov A.A., Garber M.B., Portier C.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: VK1.
    3. "Solution structure of the ribosomal RNA binding protein S15 from Thermus thermophilus."
      Berglund H., Rak A., Serganov A., Garber M.B., Haerd T.
      Nat. Struct. Biol. 4:20-23(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.
    4. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
      Strain: VK1.
    5. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF S15 AND RRNA.
      Strain: VK1.

    Entry informationi

    Entry nameiRS15_THETH
    AccessioniPrimary (citable) accession number: P80378
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3