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P80378 (RS15_THETH) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
30S ribosomal protein S15
Gene names
Name:rpsO
Synonyms:rps15
OrganismThermus thermophilus
Taxonomic identifier274 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length89 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. HAMAP-Rule MF_01343

Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome By similarity. HAMAP-Rule MF_01343

Subunit structure

Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA By similarity.

Sequence similarities

Belongs to the ribosomal protein S15P family.

Ontologies

Keywords
   LigandRNA-binding
rRNA-binding
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionrRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 898830S ribosomal protein S15 HAMAP-Rule MF_01343
PRO_0000115572

Secondary structure

............. 89
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P80378 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 9DB7E1C533DBF340

FASTA8910,554
        10         20         30         40         50         60 
MPITKEEKQK VIQEFARFPG DTGSTEVQVA LLTLRINRLS EHLKVHKKDH HSHRGLLMMV 

        70         80 
GQRRRLLRYL QREDPERYRA LIEKLGIRG 

« Hide

References

[1]"Ribosomal protein S15 from Thermus thermophilus -- cloning, sequencing, overexpression of the gene and RNA-binding properties of the protein."
Serganov A., Rak A., Garber M.B., Reinbolt J., Ehresmann B., Ehresmann C., Grunberg-Manago M., Portier C.
Eur. J. Biochem. 246:291-300(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: VK1.
[2]"Polynucleotide phosphorylase from Thermus thermophilus: cloning, sequencing and expression of the gene and biochemical properties of the enzyme."
Serganov A.A., Garber M.B., Portier C.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: VK1.
[3]"Solution structure of the ribosomal RNA binding protein S15 from Thermus thermophilus."
Berglund H., Rak A., Serganov A., Garber M.B., Haerd T.
Nat. Struct. Biol. 4:20-23(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
[4]"The crystal structure of UUCG tetraloop."
Ennifar E., Nikulin A., Tishchenko S., Serganov A., Nevskaya N., Garber M.B., Ehresmann B., Ehresmann C., Nikonov S., Dumas P.
J. Mol. Biol. 304:35-42(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
Strain: VK1.
[5]"Crystal structure of the S15-rRNA complex."
Nikulin A., Serganov A., Ennifar E., Tishchenko S., Nevskaya N., Shepard W., Portier C., Garber M.B., Ehresmann B., Ehresmann C., Nikonov S., Dumas P.
Nat. Struct. Biol. 7:273-277(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF S15 AND RRNA.
Strain: VK1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z37726 Genomic DNA. Translation: CAA85782.1.
Z84207 Genomic DNA. Translation: CAB06340.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1AB3NMR-A2-89[»]
1DK1X-ray2.80A2-87[»]
1F7YX-ray2.80A1-89[»]
1KUQX-ray2.84A1-87[»]
1PNSX-ray8.70O2-89[»]
1TWTmodel-R2-89[»]
2FKXNMR-A2-89[»]
4BYBX-ray3.35O1-89[»]
ProteinModelPortalP80378.
SMRP80378. Positions 2-89.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-6174N.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.10. 1 hit.
HAMAPMF_01343_B. Ribosomal_S15_B.
InterProIPR000589. Ribosomal_S15.
IPR005290. Ribosomal_S15_bac-type.
IPR009068. S15_NS1_RNA-bd.
[Graphical view]
PfamPF00312. Ribosomal_S15. 1 hit.
[Graphical view]
SUPFAMSSF47060. SSF47060. 1 hit.
TIGRFAMsTIGR00952. S15_bact. 1 hit.
PROSITEPS00362. RIBOSOMAL_S15. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP80378.

Entry information

Entry nameRS15_THETH
AccessionPrimary (citable) accession number: P80378
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references