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P80378

- RS15_THETH

UniProt

P80378 - RS15_THETH

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Protein
30S ribosomal protein S15
Gene
rpsO, rps15
Organism
Thermus thermophilus
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.UniRule annotation
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome By similarity.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
30S ribosomal protein S15
Gene namesi
Name:rpsO
Synonyms:rps15
OrganismiThermus thermophilus
Taxonomic identifieri274 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 898830S ribosomal protein S15UniRule annotation
PRO_0000115572Add
BLAST

Interactioni

Subunit structurei

Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA By similarity.

Protein-protein interaction databases

DIPiDIP-6174N.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1511
Beta strandi17 – 204
Helixi26 – 4520
Turni46 – 483
Helixi51 – 7323
Helixi75 – 817
Turni82 – 865

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AB3NMR-A2-89[»]
1DK1X-ray2.80A2-87[»]
1F7YX-ray2.80A1-89[»]
1KUQX-ray2.84A1-87[»]
1PNSX-ray8.70O2-89[»]
1TWTmodel-R2-89[»]
2FKXNMR-A2-89[»]
4BYBX-ray3.35O1-89[»]
ProteinModelPortaliP80378.
SMRiP80378. Positions 2-89.

Miscellaneous databases

EvolutionaryTraceiP80378.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.287.10. 1 hit.
HAMAPiMF_01343_B. Ribosomal_S15_B.
InterProiIPR000589. Ribosomal_S15.
IPR005290. Ribosomal_S15_bac-type.
IPR009068. S15_NS1_RNA-bd.
[Graphical view]
PfamiPF00312. Ribosomal_S15. 1 hit.
[Graphical view]
SUPFAMiSSF47060. SSF47060. 1 hit.
TIGRFAMsiTIGR00952. S15_bact. 1 hit.
PROSITEiPS00362. RIBOSOMAL_S15. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80378-1 [UniParc]FASTAAdd to Basket

« Hide

MPITKEEKQK VIQEFARFPG DTGSTEVQVA LLTLRINRLS EHLKVHKKDH   50
HSHRGLLMMV GQRRRLLRYL QREDPERYRA LIEKLGIRG 89
Length:89
Mass (Da):10,554
Last modified:January 23, 2007 - v3
Checksum:i9DB7E1C533DBF340
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z37726 Genomic DNA. Translation: CAA85782.1.
Z84207 Genomic DNA. Translation: CAB06340.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z37726 Genomic DNA. Translation: CAA85782.1 .
Z84207 Genomic DNA. Translation: CAB06340.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AB3 NMR - A 2-89 [» ]
1DK1 X-ray 2.80 A 2-87 [» ]
1F7Y X-ray 2.80 A 1-89 [» ]
1KUQ X-ray 2.84 A 1-87 [» ]
1PNS X-ray 8.70 O 2-89 [» ]
1TWT model - R 2-89 [» ]
2FKX NMR - A 2-89 [» ]
4BYB X-ray 3.35 O 1-89 [» ]
ProteinModelPortali P80378.
SMRi P80378. Positions 2-89.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-6174N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P80378.

Family and domain databases

Gene3Di 1.10.287.10. 1 hit.
HAMAPi MF_01343_B. Ribosomal_S15_B.
InterProi IPR000589. Ribosomal_S15.
IPR005290. Ribosomal_S15_bac-type.
IPR009068. S15_NS1_RNA-bd.
[Graphical view ]
Pfami PF00312. Ribosomal_S15. 1 hit.
[Graphical view ]
SUPFAMi SSF47060. SSF47060. 1 hit.
TIGRFAMsi TIGR00952. S15_bact. 1 hit.
PROSITEi PS00362. RIBOSOMAL_S15. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ribosomal protein S15 from Thermus thermophilus -- cloning, sequencing, overexpression of the gene and RNA-binding properties of the protein."
    Serganov A., Rak A., Garber M.B., Reinbolt J., Ehresmann B., Ehresmann C., Grunberg-Manago M., Portier C.
    Eur. J. Biochem. 246:291-300(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: VK1.
  2. "Polynucleotide phosphorylase from Thermus thermophilus: cloning, sequencing and expression of the gene and biochemical properties of the enzyme."
    Serganov A.A., Garber M.B., Portier C.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: VK1.
  3. "Solution structure of the ribosomal RNA binding protein S15 from Thermus thermophilus."
    Berglund H., Rak A., Serganov A., Garber M.B., Haerd T.
    Nat. Struct. Biol. 4:20-23(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  4. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Strain: VK1.
  5. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF S15 AND RRNA.
    Strain: VK1.

Entry informationi

Entry nameiRS15_THETH
AccessioniPrimary (citable) accession number: P80378
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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