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P80372 (RS3_THET8) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
30S ribosomal protein S3
Gene names
Name:rpsC
Synonyms:rps3
Ordered Locus Names:TTHA1686
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP]
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. HAMAP-Rule MF_01309_B

Subunit structure

Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. Ref.4 Ref.5 Ref.6 Ref.7 Ref.9 Ref.10 Ref.12 Ref.13

Sequence similarities

Belongs to the ribosomal protein S3P family.

Contains 1 KH type-2 domain.

Mass spectrometry

Molecular mass is 26570 Da from positions 2 - 239. Determined by MALDI. Ref.3

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 23923830S ribosomal protein S3 HAMAP-Rule MF_01309_B
PRO_0000130223

Regions

Domain39 – 10769KH type-2

Secondary structure

.................................................. 239
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P80372 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: AD585A1D53AC7F04

FASTA23926,701
        10         20         30         40         50         60 
MGNKIHPIGF RLGITRDWES RWYAGKKQYR HLLLEDQRIR GLLEKELYSA GLARVDIERA 

        70         80         90        100        110        120 
ADNVAVTVHV AKPGVVIGRG GERIRVLREE LAKLTGKNVA LNVQEVQNPN LSAPLVAQRV 

       130        140        150        160        170        180 
AEQIERRFAV RRAIKQAVQR VMESGAKGAK VIVSGRIGGA EQARTEWAAQ GRVPLHTLRA 

       190        200        210        220        230 
NIDYGFALAR TTYGVLGVKA YIFLGEVIGG QKPKARPELP KAEERPRRRR PAVRVKKEE 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[2]"Purification and characterization of the 30S ribosomal proteins from the bacterium Thermus thermophilus."
Tsiboli P., Herfurth E., Choli T.
Eur. J. Biochem. 226:169-177(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-37.
[3]"Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry."
Suh M.-J., Hamburg D.M., Gregory S.T., Dahlberg A.E., Limbach P.A.
Proteomics 5:4818-4831(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: MASS SPECTROMETRY.
[4]"Structure of the 30S ribosomal subunit."
Wimberly B.T., Brodersen D.E., Clemons W.M. Jr., Morgan-Warren R.J., Carter A.P., Vonrhein C., Hartsch T., Ramakrishnan V.
Nature 407:327-339(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF THE 30S SUBUNIT.
[5]"Structure of functionally activated small ribosomal subunit at 3.3 A resolution."
Schluenzen F., Tocilj A., Zarivach R., Harms J., Gluehmann M., Janell D., Bashan A., Bartels H., Agmon I., Franceschi F., Yonath A.
Cell 102:615-623(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 30S SUBUNIT.
[6]"The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit."
Brodersen D.E., Clemons W.M. Jr., Carter A.P., Morgan-Warren R.J., Wimberly B.T., Ramakrishnan V.
Cell 103:1143-1154(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 30S SUBUNIT.
[7]"Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics."
Carter A.P., Clemons W.M. Jr., Brodersen D.E., Morgan-Warren R.J., Wimberly B.T., Ramakrishnan V.
Nature 407:340-348(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 30S SUBUNIT.
[8]"The path of messenger RNA through the ribosome."
Yusupova G.Z., Yusupov M.M., Cate J.H.D., Noller H.F.
Cell 106:233-241(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (5.0 ANGSTROMS) OF THE RIBOSOME.
[9]"Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3."
Pioletti M., Schluenzen F., Harms J., Zarivach R., Gluehmann M., Avila H., Bashan A., Bartels H., Auerbach T., Jacobi C., Hartsch T., Yonath A., Franceschi F.
EMBO J. 20:1829-1839(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF THE 30S SUBUNIT.
[10]"Crystal structure of an initiation factor bound to the 30S ribosomal subunit."
Carter A.P., Clemons W.M. Jr., Brodersen D.E., Morgan-Warren R.J., Hartsch T., Wimberly B.T., Ramakrishnan V.
Science 291:498-501(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF THE 30S SUBUNIT.
[11]"Crystal structure of the ribosome at 5.5 A resolution."
Yusupov M.M., Yusupova G.Z., Baucom A., Lieberman K., Earnest T.N., Cate J.H.D., Noller H.F.
Science 292:883-896(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE RIBOSOME.
[12]"Recognition of cognate transfer RNA by the 30S ribosomal subunit."
Ogle J.M., Brodersen D.E., Clemons W.M. Jr., Tarry M.J., Carter A.P., Ramakrishnan V.
Science 292:897-902(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.11 ANGSTROMS) OF THE 30S SUBUNIT.
[13]"Crystal structure of the 30S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16S RNA."
Brodersen D.E., Clemons W.M. Jr., Carter A.P., Wimberly B.T., Ramakrishnan V.
J. Mol. Biol. 316:725-768(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF THE 30S SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008226 Genomic DNA. Translation: BAD71509.1.
RefSeqYP_144952.1. NC_006461.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FJGX-ray3.00C1-239[»]
1GIXX-ray5.50F1-239[»]
1HNWX-ray3.40C1-239[»]
1HNXX-ray3.40C1-239[»]
1HNZX-ray3.30C1-239[»]
1HR0X-ray3.20C1-239[»]
1I94X-ray3.20C2-239[»]
1I95X-ray4.50C2-239[»]
1I96X-ray4.20C2-239[»]
1I97X-ray4.50C2-239[»]
1IBKX-ray3.31C1-239[»]
1IBLX-ray3.11C1-239[»]
1IBMX-ray3.31C1-239[»]
1J5EX-ray3.05C1-239[»]
1L1Umodel-C1-207[»]
1ML5electron microscopy14.00F1-239[»]
1N32X-ray3.00C1-239[»]
1N33X-ray3.35C1-239[»]
1N34X-ray3.80C1-239[»]
1N36X-ray3.65C1-239[»]
1PNSX-ray8.70C2-207[»]
1PNXX-ray9.50C2-207[»]
1XMOX-ray3.25C1-239[»]
1XMQX-ray3.00C1-239[»]
1XNQX-ray3.05C1-239[»]
1XNRX-ray3.10C1-239[»]
1YL4X-ray5.50F1-239[»]
2B64X-ray5.90C1-239[»]
2B9MX-ray6.76C1-239[»]
2B9OX-ray6.46C1-239[»]
2E5LX-ray3.30C2-239[»]
2F4VX-ray3.80C1-239[»]
2HGIX-ray5.00F1-239[»]
2HGPX-ray5.50F1-239[»]
2HGRX-ray4.51F1-239[»]
2HHHX-ray3.35C1-239[»]
2J00X-ray2.80C2-239[»]
2J02X-ray2.80C2-239[»]
2UU9X-ray3.10C2-239[»]
2UUAX-ray2.90C2-239[»]
2UUBX-ray2.80C2-239[»]
2UUCX-ray3.10C2-239[»]
2UXBX-ray3.10C2-239[»]
2UXCX-ray2.90C2-239[»]
2UXDX-ray3.20C2-239[»]
2V46X-ray3.50C2-239[»]
2V48X-ray3.50C2-239[»]
2VQEX-ray2.50C1-239[»]
2VQFX-ray2.90C1-239[»]
2WDGX-ray3.30C1-239[»]
2WDHX-ray3.30C1-239[»]
2WDKX-ray3.50C1-239[»]
2WDMX-ray3.50C1-239[»]
2WH1X-ray3.45C1-239[»]
2WH3X-ray3.45C1-239[»]
2WRIX-ray3.60C1-239[»]
2WRKX-ray3.60C1-239[»]
2WRNX-ray3.60C1-239[»]
2WRQX-ray3.60C1-239[»]
2X9RX-ray3.10C1-239[»]
2X9TX-ray3.10C1-239[»]
2XFZX-ray3.20C1-239[»]
2XG1X-ray3.20C1-239[»]
2XQDX-ray3.10C1-239[»]
2XSYelectron microscopy7.80C1-239[»]
2XUYelectron microscopy7.60C1-239[»]
2Y0UX-ray3.10C1-239[»]
2Y0WX-ray3.10C1-239[»]
2Y0YX-ray3.10C1-239[»]
2Y10X-ray3.10C1-239[»]
2Y12X-ray3.10C1-239[»]
2Y14X-ray3.10C1-239[»]
2Y16X-ray3.10C1-239[»]
2Y18X-ray3.10C1-239[»]
2ZM6X-ray3.30C2-239[»]
3FICelectron microscopy6.40C2-208[»]
3HUWX-ray3.10C1-239[»]
3HUYX-ray3.10C1-239[»]
3I8GX-ray3.10F1-239[»]
3I8HX-ray3.10F1-239[»]
3I9BX-ray3.50F1-239[»]
3I9DX-ray3.50F1-239[»]
3KIQX-ray3.30c1-239[»]
3KISX-ray3.30c1-239[»]
3KIUX-ray3.60c1-239[»]
3KIXX-ray3.60c1-239[»]
3KNHX-ray3.00C1-239[»]
3KNJX-ray3.15C1-239[»]
3KNLX-ray3.45C1-239[»]
3KNNX-ray3.45C1-239[»]
3OGEX-ray3.00C1-239[»]
3OGYX-ray3.00C1-239[»]
3OHCX-ray3.00C1-239[»]
3OHDX-ray3.00C1-239[»]
3OHYX-ray3.00C1-239[»]
3OI0X-ray3.00C1-239[»]
3OI2X-ray3.10C1-239[»]
3OI4X-ray3.10C1-239[»]
3OTOX-ray3.69C1-239[»]
3T1HX-ray3.11C1-239[»]
3T1YX-ray2.80C1-239[»]
3TVFX-ray3.10F1-239[»]
3TVGX-ray3.10F1-239[»]
3UXSX-ray3.20C1-239[»]
3UXTX-ray3.20C1-239[»]
3UYDX-ray3.00F1-239[»]
3UYFX-ray3.00F1-239[»]
3UZ3X-ray3.30F1-239[»]
3UZ4X-ray3.30F1-239[»]
3UZ6X-ray3.00F1-239[»]
3UZ7X-ray3.00F1-239[»]
3UZGX-ray3.30F1-239[»]
3UZIX-ray3.30F1-239[»]
3UZLX-ray3.30F1-239[»]
3UZMX-ray3.30F1-239[»]
3V22X-ray3.00C1-239[»]
3V24X-ray3.00C1-239[»]
3V26X-ray3.10C1-239[»]
3V28X-ray3.10C1-239[»]
3V2CX-ray2.70C1-239[»]
3V2EX-ray2.70C1-239[»]
3V6UX-ray3.90C1-239[»]
3V6VX-ray3.90C1-239[»]
3ZN7X-ray3.10C1-239[»]
3ZNDX-ray3.10C1-239[»]
3ZVOX-ray3.80C1-239[»]
4ABRX-ray3.10C1-239[»]
4AQYX-ray3.50C1-239[»]
4B3MX-ray2.90C1-239[»]
4B3RX-ray3.00C1-239[»]
4B3SX-ray3.15C1-239[»]
4B3TX-ray3.00C1-239[»]
4B8FX-ray3.70C1-239[»]
4B8HX-ray3.70C1-239[»]
4BYBX-ray3.35C1-239[»]
4BYDX-ray3.35C1-239[»]
4CR1X-ray2.95C1-239[»]
4DH9X-ray3.20C1-239[»]
4DHBX-ray3.20C1-239[»]
4DR1X-ray3.60C1-239[»]
4DR2X-ray3.25C1-239[»]
4DR3X-ray3.35C1-239[»]
4DR4X-ray3.97C1-239[»]
4DR5X-ray3.45C1-239[»]
4DR6X-ray3.30C1-239[»]
4DR7X-ray3.75C1-239[»]
4DUYX-ray3.39C1-239[»]
4DUZX-ray3.65C1-239[»]
4DV0X-ray3.85C1-239[»]
4DV1X-ray3.85C1-239[»]
4DV2X-ray3.65C1-239[»]
4DV3X-ray3.55C1-239[»]
4DV4X-ray3.65C1-239[»]
4DV5X-ray3.68C1-239[»]
4DV6X-ray3.30C1-239[»]
4DV7X-ray3.29C1-239[»]
4EJ9X-ray3.52C1-239[»]
4EJAX-ray3.52C1-239[»]
4G5KX-ray3.30F1-239[»]
4G5MX-ray3.30F1-239[»]
4G5TX-ray3.10F1-239[»]
4G5VX-ray3.10F1-239[»]
4GKJX-ray3.30C2-207[»]
4GKKX-ray3.20C2-207[»]
4JI0X-ray3.49C1-239[»]
4JI1X-ray3.14C1-239[»]
4JI2X-ray3.64C1-239[»]
4JI3X-ray3.35C1-239[»]
4JI4X-ray3.69C1-239[»]
4JI5X-ray3.85C1-239[»]
4JI6X-ray3.55C1-239[»]
4JI7X-ray3.50C1-239[»]
4JI8X-ray3.74C1-239[»]
4JUWX-ray2.86C2-207[»]
4JV5X-ray3.16C2-207[»]
4JYAX-ray3.10C2-207[»]
4K0KX-ray3.40C2-208[»]
4K0LX-ray3.30C2-207[»]
4K0PX-ray3.30C2-207[»]
4KHPX-ray3.10C2-207[»]
4NVUX-ray3.00C1-239[»]
4NVWX-ray3.00C1-239[»]
4NVYX-ray3.10C1-239[»]
4NW0X-ray3.10C1-239[»]
4NXMX-ray3.65C1-239[»]
4NXNX-ray3.54C1-239[»]
4OX9X-ray3.80C1-239[»]
ProteinModelPortalP80372.
SMRP80372. Positions 2-207.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING300852.TTHA1686.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD71509; BAD71509; BAD71509.
GeneID3168725.
KEGGttj:TTHA1686.
PATRIC23958327. VBITheThe93045_1656.

Phylogenomic databases

eggNOGCOG0092.
HOGENOMHOG000210610.
KOK02982.
OMAIARAEWY.
OrthoDBEOG6K13X3.
PhylomeDBP80372.

Enzyme and pathway databases

BioCycTTHE300852:GH8R-1725-MONOMER.

Family and domain databases

Gene3D3.30.1140.32. 1 hit.
3.30.300.20. 1 hit.
HAMAPMF_01309_B. Ribosomal_S3_B.
InterProIPR004087. KH_dom.
IPR015946. KH_dom-like_a/b.
IPR004044. KH_dom_type_2.
IPR009019. KH_prok-type.
IPR005704. Ribosomal_S3_bac.
IPR001351. Ribosomal_S3_C.
IPR018280. Ribosomal_S3_CS.
[Graphical view]
PfamPF07650. KH_2. 1 hit.
PF00189. Ribosomal_S3_C. 1 hit.
[Graphical view]
SMARTSM00322. KH. 1 hit.
[Graphical view]
SUPFAMSSF54814. SSF54814. 1 hit.
SSF54821. SSF54821. 1 hit.
TIGRFAMsTIGR01009. rpsC_bact. 1 hit.
PROSITEPS50823. KH_TYPE_2. 1 hit.
PS00548. RIBOSOMAL_S3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP80372.

Entry information

Entry nameRS3_THET8
AccessionPrimary (citable) accession number: P80372
Secondary accession number(s): Q5SHP4, Q9ACK0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references