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P80357 (ASTA_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Arginine N-succinyltransferase subunit alpha
Short name=ARUAI
EC=2.3.1.109
Alternative name(s):
AOST
Short name=AST
Gene names
Name:astA
Synonyms:aruF
Ordered Locus Names:PA0896
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. Also acts on L-ornithine.

Catalytic activity

Succinyl-CoA + L-arginine = CoA + N(2)-succinyl-L-arginine.

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 1/5.

Subunit structure

Heterotetramer of two alpha and two beta subunits.

Sequence similarities

Belongs to the succinylarginine dihydrolase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Arginine N-succinyltransferase subunit alpha
PRO_0000064714

Secondary structure

1 ................................................................ 338
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P80357 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: 7152BB5EC220F719

FASTA33836,931
        10         20         30         40         50         60 
MLVMRPAQAA DLPQVQRLAA DSPVGVTSLP DDAERLRDKI LASEASFAAE VSYNGEESYF 

        70         80         90        100        110        120 
FVLEDSASGE LVGCSAIVAS AGFSEPFYSF RNETFVHASR SLSIHNKIHV LSLCHDLTGN 

       130        140        150        160        170        180 
SLLTSFYVQR DLVQSVYAEL NSRGRLLFMA SHPERFADAV VVEIVGYSDE QGESPFWNAV 

       190        200        210        220        230        240 
GRNFFDLNYI EAEKLSGLKS RTFLAELMPH YPIYVPLLPD AAQESMGQVH PRAQITFDIL 

       250        260        270        280        290        300 
MREGFETDNY IDIFDGGPTL HARTSGIRSI AQSRVVPVKI GEAPKSGRPY LVTNGQLQDF 

       310        320        330 
RAVVLDLDWA PGKPVALSVE AAEALGVGEG ASVRLVAV

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa."
Itoh Y.
J. Bacteriol. 179:7280-7290(1997) [PubMed: 9393691] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
[2]"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen."
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. expand/collapse author list , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.
Nature 406:959-964(2000) [PubMed: 10984043] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
[3]"Purification and properties of a succinyltransferase from Pseudomonas aeruginosa specific for both arginine and ornithine."
Tricot C., Vander Wauven C., Wattiez R., Falmagne P., Stalon V.
Eur. J. Biochem. 224:853-861(1994) [PubMed: 7523119] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-11.
Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF011922 Genomic DNA. Translation: AAC46010.1.
AE004091 Genomic DNA. Translation: AAG04285.1.
PIRA83533.
RefSeqNP_249587.1. NC_002516.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1YLEX-ray1.70A1-338[»]
ProteinModelPortalP80357.
SMRP80357. Positions 1-338.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID879437.
GenomeReviewsGene locus PA0896 in contig AE004091_GR.
KEGGpae:PA0896.
PATRIC19836078. VBIPseAer58763_0931.

Organism-specific databases

PseudoCAPPA0896.

Phylogenomic databases

HOGENOMHBG377601.
OMAQEAMGQV.
ProtClustDBCLSK866199.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-11524.
PAER208964:PA0896-MONOMER.

Family and domain databases

InterProIPR016181. Acyl_CoA_acyltransferase.
IPR017651. Arg/Orn_succinylTfrase_asu.
IPR007041. Arg_N-succinylTrfase_Ast/AOST.
[Graphical view]
Gene3DG3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
KOK00673.
PfamPF04958. AstA. 1 hit.
[Graphical view]
SUPFAMSSF55729. Acyl_CoA_acyltransferase. 1 hit.
TIGRFAMsTIGR03245. Arg_AOST_alph. 1 hit.
TIGR03243. Arg_catab_AOST. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASTA_PSEAE
AccessionPrimary (citable) accession number: P80357
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 15, 1999
Last modified: January 25, 2012
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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