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P80343

- MCPB_BOVIN

UniProt

P80343 - MCPB_BOVIN

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Protein

Monocyte chemotactic protein 1B

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts monocytes, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin.

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Monocyte chemotactic protein 1B
Short name:
MCP-1B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 74›74Monocyte chemotactic protein 1BPRO_0000144304Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi9 ↔ 34By similarity
Disulfide bondi10 ↔ 50By similarity

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP80343.

Structurei

3D structure databases

ProteinModelPortaliP80343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P80343-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
DAINSPVTCC YTLTSKKISM QRLMSYRRVT SSKCPKEAVI FKTIAGKEIC
60 70
AEPKXXWVQD SISHLDKKNQ XPKP
Length:74
Mass (Da):8,363
Last modified:February 1, 1995 - v1
Checksum:iFAAF72B970EB16E3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

PIRiA55984.

Cross-referencesi

Sequence databases

PIRi A55984.

3D structure databases

ProteinModelPortali P80343.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P80343.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Purification, sequence analysis, and biological characterization of a second bovine monocyte chemotactic protein-1 (Bo MCP-1B)."
    Proost P., Wuyts A., Lenaerts J.-P., van Damme J.
    Biochemistry 33:13406-13412(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Kidney.

Entry informationi

Entry nameiMCPB_BOVIN
AccessioniPrimary (citable) accession number: P80343
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3