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Protein

Monocyte chemotactic protein 1B

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts monocytes, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Heparin-binding
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Monocyte chemotactic protein 1B
Short name:
MCP-1B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000144304‹1 – 74Monocyte chemotactic protein 1BAdd BLAST›74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi9 ↔ 34By similarity
Disulfide bondi10 ↔ 50By similarity

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP80343.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP80343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.

Sequencei

Sequence statusi: Fragment.

P80343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DAINSPVTCC YTLTSKKISM QRLMSYRRVT SSKCPKEAVI FKTIAGKEIC
60 70
AEPKXXWVQD SISHLDKKNQ XPKP
Length:74
Mass (Da):8,363
Last modified:February 1, 1995 - v1
Checksum:iFAAF72B970EB16E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

PIRiA55984.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMCPB_BOVIN
AccessioniPrimary (citable) accession number: P80343
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 10, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families