Reviewed, UniProtKB/Swiss-Prot P80342 (CATL2_FASHE)

Names and origin

Protein names	Recommended name:     Cathepsin L2     EC=3.4.22.15
Organism	Fasciola hepatica (Liver fluke)
Taxonomic identifier	6192 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Platyhelminthes › Trematoda › Digenea › Echinostomida › Echinostomata › Echinostomatoidea › Fasciolidae › Fasciola

Protein attributes

Sequence length	14 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Thiol protease that assists the parasite in burrowing through the gut wall and liver of its mammalian host.
Catalytic activity	Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
Subunit structure	Dimer of a heavy and a light chain linked by disulfide bonds.
Subcellular location	Lysosome.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Cellular component	Lysosome
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›14	›14	Cathepsin L2		PRO_0000050539
Experimental info
	Non-terminal residue	14	1

Sequences

	Sequence		Length	Mass (Da)
	P80342-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 9CAEAB74E9DA110A	FASTA	14	1,605
	10 AVPDKIDRRE SGYV

References

[1]	"Purification and characterisation of a second cathepsin L proteinase secreted by the parasitic trematode Fasciola hepatica." Dowd A.J., Smith A.M., McGonicle S., Dalton J.P. Eur. J. Biochem. 223:91-98(1994) [PubMed: 8033913] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	S45655.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.4.22.15. 39370.
Family and domain databases
InterPro	IPR000169. Pept_cys_AS. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. Partial match. PS00139. THIOL_PROTEASE_CYS. Partial match. PS00639. THIOL_PROTEASE_HIS. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATL2_FASHE

Accession

Primary (citable) accession number: P80342

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)