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P80342 - CATL2_FASHE
- Names & Taxonomy
- Subcellular locationSubcell. location
- Pathology & BiotechPathol./Biotech
- PTM / Processing
- Family & Domains
- Entry information
- BLAST>sp|P80342|CATL2_FASHE Cathepsin L2 (Fragment) OS=Fasciola hepatica PE=1 SV=1 AVPDKIDRRESGYV
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Select a section on the left to see content.Thiol protease that assists the parasite in burrowing through the gut wall and liver of its mammalian host.Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
Recommended name:Cathepsin L2 (EC:22.214.171.124)
- cysteine-type peptidase activity Source: UniProtKB-KW
Fasciola hepatica (Liver fluke) 6192 [NCBI] cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Platyhelminthes › Trematoda › Digenea › Echinostomida › Echinostomata › Echinostomatoidea › Fasciolidae › Fasciola
- lysosome Source: UniProtKB-SubCell
<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi
Feature key Position(s) Length Description Graphical view Feature identifier Actions <p>Describes the extent of a polypeptide chain in the mature protein following processing.</p><p><a href='../manual/chain' target='_top'>More...</a></p>Chaini 1 – ›14 ›14 Cathepsin L2 PRO_0000050539 Add
<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='../help/keywords' target='_top'>More...</a></p>Keywords - PTMiDisulfide bond
<p>Provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the ‘Function’ section).</p><p><a href='../manual/subunit_structure' target='_top'>More...</a></p>Subunit structureiDimer of a heavy and a light chain linked by disulfide bonds.Belongs to the peptidase C1 family.PROSITE-ProRule annotation
<p>Indicates if the canonical sequence displayed by default in the entry is complete or not.</p><p><a href='../manual/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.Length:14Mass (Da):1,605Last modified:October 1, 1994 - v1<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CAEAB74E9DA110A
Feature key Position(s) Length Description Graphical view Feature identifier Actions <p>Is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.</p><p><a href='../manual/non_ter' target='_top'>More...</a></p>Non-terminal residuei 14 – 14 1
Protein sequence database of the Protein Information Resource<br/><a href='/database/78'>More..</a>PIRi S45655.
Protein sequence database of the Protein Information Resource<br/><a href='/database/78'>More..</a> PIRi S45655.
3D structure databases
Database of comparative protein structure models<br/><a href='/database/63'>More..</a> ModBasei Search... Search...
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Family and domain databases
Search... CATL2_FASHE P80342Primary (citable) accession number: P80342 Integrated into UniProtKB/Swiss-Prot: October 1, 1994 Last sequence update: October 1, 1994 Last modified: October 1, 2014 This is version 58 of the entry and version 1 of the sequence. [Complete history] Reviewed (UniProtKB/Swiss-Prot)
- Peptidase familiesClassification of peptidase families and list of entries
- SIMILARITY commentsIndex of protein domains and families
External DataDasty 3