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P80342

- CATL2_FASHE

UniProt

P80342 - CATL2_FASHE

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Protein
Cathepsin L2
Gene
N/A
Organism
Fasciola hepatica (Liver fluke)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Thiol protease that assists the parasite in burrowing through the gut wall and liver of its mammalian host.

Catalytic activityi

Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin L2 (EC:3.4.22.15)
OrganismiFasciola hepatica (Liver fluke)
Taxonomic identifieri6192 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaEchinostomidaEchinostomataEchinostomatoideaFasciolidaeFasciola

Subcellular locationi

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›14›14Cathepsin L2
PRO_0000050539Add
BLAST

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Dimer of a heavy and a light chain linked by disulfide bonds.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.

Sequencei

Sequence statusi: Fragment.

P80342-1 [UniParc]FASTAAdd to Basket

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AVPDKIDRRE SGYV                                          14
Length:14
Mass (Da):1,605
Last modified:October 1, 1994 - v1
Checksum:i9CAEAB74E9DA110A
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei14 – 141

Sequence databases

PIRiS45655.

Cross-referencesi

Sequence databases

PIRi S45655.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Purification and characterisation of a second cathepsin L proteinase secreted by the parasitic trematode Fasciola hepatica."
    Dowd A.J., Smith A.M., McGonicle S., Dalton J.P.
    Eur. J. Biochem. 223:91-98(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiCATL2_FASHE
AccessioniPrimary (citable) accession number: P80342
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3