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P80342

- CATL2_FASHE

UniProt

P80342 - CATL2_FASHE

Protein

Cathepsin L2

Gene
N/A
Organism
Fasciola hepatica (Liver fluke)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Thiol protease that assists the parasite in burrowing through the gut wall and liver of its mammalian host.

    Catalytic activityi

    Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cathepsin L2 (EC:3.4.22.15)
    OrganismiFasciola hepatica (Liver fluke)
    Taxonomic identifieri6192 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaEchinostomidaEchinostomataEchinostomatoideaFasciolidaeFasciola

    Subcellular locationi

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›14›14Cathepsin L2PRO_0000050539Add
    BLAST

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Dimer of a heavy and a light chain linked by disulfide bonds.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Sequencei

    Sequence statusi: Fragment.

    P80342-1 [UniParc]FASTAAdd to Basket

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    AVPDKIDRRE SGYV                                          14
    Length:14
    Mass (Da):1,605
    Last modified:October 1, 1994 - v1
    Checksum:i9CAEAB74E9DA110A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei14 – 141

    Sequence databases

    PIRiS45655.

    Cross-referencesi

    Sequence databases

    PIRi S45655.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Purification and characterisation of a second cathepsin L proteinase secreted by the parasitic trematode Fasciola hepatica."
      Dowd A.J., Smith A.M., McGonicle S., Dalton J.P.
      Eur. J. Biochem. 223:91-98(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiCATL2_FASHE
    AccessioniPrimary (citable) accession number: P80342
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3